Toxicokinetics and hydrolysis of artelinate and artesunate in malaria-infected rats

International Journal of Toxicology

Volumn 24, Issue 4, 2005, Pages 241-250

  Li, Qigui ^a   Xie, Lisa H ^a   Si, Yuanzheng ^a   Wong, Elaine ^a   Upadhyay, Ravi ^a   Yanez, Danielle ^a   Weina, Peter J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Antimalarial; Artelinate; Artesunate; Dihydroartemisinin; Hydrolysis; Malaria Infected Rats; Toxicokinetics

Indexed keywords

ANTIMALARIAL AGENT; ARTELINIC ACID; ARTESUNATE; DIHYDROARTEMISININ; DRUG METABOLIZING ENZYME;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; ENTEROHEPATIC CIRCULATION; HYDROLYSIS; LIVER METABOLISM; MALARIA; MALE; MOLECULAR DYNAMICS; NONHUMAN; RAT; TISSUE DISTRIBUTION; TOXICOKINETICS;

ANIMALS; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; DISEASE MODELS, ANIMAL; HALF-LIFE; HYDROLYSIS; INJECTIONS, INTRAVENOUS; LIVER; MALARIA; METABOLIC CLEARANCE RATE; PLASMODIUM BERGHEI; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; TISSUE DISTRIBUTION;

ARTESUNATE;

EID: 23744454613     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810591007201     Document Type: Article

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