Thrombin, TNF-α, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 2 58-2, 2005, Pages

  Wu, Sheng Qian ^a   Aird, William C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Activation; Tumor necrosis factor

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR A; PROTEIN KINASE C; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; UROKINASE;

ARTICLE; CELL ACTIVATION; CELL TYPE; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN INDUCTION; PULMONARY ARTERY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLATELET-DERIVED GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; THROMBIN; THROMBOPLASTIN; TUMOR NECROSIS FACTOR-ALPHA; URINARY PLASMINOGEN ACTIVATOR;

EID: 23744451240     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00993.2004     Document Type: Article

References (66)

1. Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C, and Aird WC. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J Biol Chem 279: 44030-44038, 2004.
2. Aird WC. Endothelial cell heterogeneity. Crit Care Med 31: S221-S230, 2003.
3. Aird WC. Endothelium as an organ system. Crit Care Med 32: S271-S279, 2004.
4. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101: 3765-3777, 2003.
5. Aird WC. Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis. Crit Care Med 29: S28-S35, 2001.
6. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, and Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262: 5592-5595, 1987.
7. Alessi DR, Cuenda A, Cohen P, Dudley DT, and Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494, 1995.
8. Bandman O, Coleman RT, Loring JF, Seilhamer JJ, and Cocks BG. Complexity of inflammatory responses in endothelial cells and vascular smooth muscle cells determined by microarray analysis. Ann NY Acad Sci 975: 77-90, 2002.
9. Bartoli M, Platt D, Lemtalsi T, Gu X, Brooks SE, Marrero MB, and Caldwell RB. VEGF differentially activates STAT3 in microvascular endothelial cells. FASEB J 17: 1562-1564, 2003.
10. Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, and Gimbrone MA Jr. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 160: 618-623, 1984.
11. Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, and Gimbrone MA Jr. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc Natl Acad Sci USA 83: 4533-4537, 1986.
12. Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, and Gimbrone MA Jr. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci USA 84: 9238-9242, 1987.
13. Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, and Gimbrone MA Jr. Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. Am J Pathol 121: 394-403, 1985.
14. Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, and Gimbrone MA Jr. Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest 76: 2003-2011, 1985.
15. Bevilacqua MP, Stengelin S, Gimbrone MA Jr, and Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243: 1160-1165, 1989.
16. Cattaruzza M, Slodowski W, Stojakovic M, Krzesz R, and Hecker M. Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells. J Biol Chem 278: 37874-37880, 2003.
17. Cavusoglu E, Chen I, Rappaport J, and Marmur JD. Inhibition of tissue factor gene induction and activity using a hairpin ribozyme. Circulation 105: 2282-2287, 2002.
18. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, and Hidaka H. Inhibition of forskolin-induced neunte outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265: 5267-5272, 1990.
19. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, and Stern DM. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91: 3527-3561, 1998.
20. Cotran RS, Gimbrone MA Jr, Bevilacqua MP, Mendrick DL, and Pober JS. Induction and detection of a human endothelial activation antigen in vivo. J Exp Med 164: 661-666, 1986.
21. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, and Lee JC. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364: 229-233, 1995.
22. Day RM, Thiel G, Lum J, Chevere RD, Yang Y, Stevens J, Sibert L, and Fanburg BL. Hepatocyte growth factor regulates angiotensin converting enzyme expression. J Biol Chem 279: 8792-8801, 2004.
23. Dechend R, Maass M, Gieffers J, Dietz R, Scheidereit C, Leutz A, and Gulba DC. Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis. Circulation 100: 1369-1373, 1999.
24. Deo DD, Axelrad TW, Robert EG, Marcheselli V, Bazan NG, and Hunt JD. Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism. J Biol Chem 211: 21237-21245, 2002.
25. Deo DD, Bazan NG, and Hunt JD. Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells. J Biol Chem 279: 3497-3508, 2004.
26. Dschietzig T, Bartsch C, Richter C, Laule M, Baumann G, and Stangl K. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circ Res 92: 32-40, 2003.
27. Ebner K, Bandion A, Binder BR, de Martin R, and Schmid JA. GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta. Blood 102: 192-199, 2003.
28. Eto M, Kozai T, Cosentino F, Joch H, and Luscher TF. Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. Circulation 105: 1756-1759, 2002.
29. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, and Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
30. Gamble JR, Harlan JM, Klebanoff SJ, and Vadas MA. Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci USA 82: 8667-8671, 1985.
31. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199: 93-98, 1994.
32. Hasan RN, Phukan S, and Harada S. Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial cells. Arterioscler Thromb Vasc Biol 23: 988-993, 2003.
33. Hidaka H, Inagaki M, Kawamoto S, and Sasaki Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23: 5036-5041, 1984.
34. Kadl A, Huber J, Gruber F, Bochkov VN, Binder BR, and Leitinger N. Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR compared with effects of LPS. Vascul Pharmacol 38: 219-227, 2002.
35. Klein S, de Fougerolles AR, Blaikie P, Khan L, Pepe A, Green CD, Koteliansky V, and Giancotti FG. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol 22: 5912-5922, 2002.
36. Kolyada AY and Madias NE. Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells. Mol Med 7: 329-343, 2001.
37. Kouroedov A, Eto M, Joch H, Volpe M, Luscher TF, and Cosentino F. Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110: 91-96, 2004.
38. Li X, Tupper JC, Bannerman DD, Winn RK, Rhodes CJ, and Harlan JM. Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun 71: 4414-4420, 2003.
39. Lo LW, Cheng JJ, Chiu JJ, Wung BS, Liu YC, and Wang DL. Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Ras/Raf-1/ERK1/2 pathway. J Cell Physiol 188: 304-312, 2001.
40. Lucerna M, Mechtcheriakova D, Kadi A, Schabbauer G, Schafer R, Gruber F, Koshelnick Y, Muller HD, Issbrucker K, Clauss M, Binder BR, and Hofer E. NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. J Biol Chem 278: 11433-11440, 2003.
41. Matsunaga T, Hokari S, Koyama I, Harada T, and Komoda T. NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein. Biochem Biophys Res Commun 303: 313-319, 2003.
42. Minami T, Abid MR, Zhang J, King G, Kodama T, and Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem 278: 6976-6984, 2003.
43. Minami T and Aird WC. Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs. J Biol Chem 276: 47632-47641, 2001.
44. Minami T, Sugiyama A, Wu SQ, Abid R, Kodama T, and Aird WC. Thrombin and phenotypic modulation of the endothelium. Arterioscler Thromb Vasc Biol 24: 41-53, 2004.
45. Miyashita H, Kanemura M, Yamazaki T, Abe M, and Sato Y. Vascular endothelial zinc finger 1 is involved in the regulation of angiogenesis: possible contribution of stathmin/OP18 as a downstream target gene. Arterioscler Thromb Vasc Biol 24: 878-884, 2004.
46. Morel JC, Park CC, Woods JM, and Koch AE. A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (P1) 3-kinase-dependent signal transduction pathways. J Biol Chem 276: 37069-37075, 2001.
47. Ni CW, Hsieh HJ, Chao YJ, and Wang DL. Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow. Am J Physiol Cell Physiol 287: C771-C780, 2004.
48. + influx in normal and transformed cells. Am J Physiol Cell Physiol 248: C288-C295, 1985.
49. Pober JS. Endothelial activation: intracellular signaling pathways. Arthritis Res 4, Suppl3: S109-S116, 2002.
50. Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, and Gimbrone MA Jr. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 136: 1680-1687, 1986.
51. Pober JS and Cotran RS. Cytokines and endothelial cell biology. Physiol Rev 70: 427-451, 1990.
52. Pober JS and Gimbrone MA Jr. Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation. Proc Natl Acad Sci USA 79: 6641-6645, 1982.
53. Pober JS, Gimbrone MA Jr, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, and Springer TA. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 137: 1893-1896, 1986.
54. Rahman A, Anwar KN, Uddin S, Xu N, Ye RD, Platanias LC, and Malik AB. Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase. Mol Cell Biol 21: 5554-5565, 2001.
55. Roberts JR, Rowe PA, and Demaine AG. Activation of NF-kappaB and MAP kinase cascades by hypothermic stress in endothelial cells. Cryobiology 44: 161-169, 2002.
56. Schleimer RP and Rutledge BK. Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters. J Immunol 136: 649-654, 1986.
57. Seynaeve CM, Kazanietz MG, Blumberg PM, Sausville EA, and Worland PJ. Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol 45: 1207-1214, 1994.
58. Speidel CM, Eisenberg PR, Ruf W, Edgington TS, and Abendschein DR. Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits. Circulation 92: 3323-3330, 1995.
59. Suganami E, Takagi H, Ohashi H, Suzuma K, Suzuma I, Oh H, Watanabe D, Ojima T, Suganami T, Fujio Y, Nakao K, Ogawa Y, and Yoshimura N. Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. Diabetes 53: 2443-2448, 2004.
60. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D, and Kirilovsky J. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266: 15771-15781, 1991.
61. Tremoli E, Camera M, Toschi V, and Colli S. Tissue factor in atherosclerosis. Atherosclerosis 144: 273-283, 1999.
62. Viemann D, Goebeler M, Schmid S, Klimmek K, Sorg C, Ludwig S, and Roth J. Transcriptional profiling of IKK2/NF-kappa B- and p38 MAP kinase-dependent gene expression in TNF-alpha-stimulated primary human endothelial cells. Blood 103: 3365-3373, 2004.
63. Vlahos CJ, Matter WF, Hui KY, and Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269: 5241-5248, 1994.
64. Wu S, Minami T, Donovan DJ, and Aird WC. The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood 100: 4454-4461, 2002.
65. Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, Cole AL, Reddy ST, and Berliner JA. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 279: 30175-30181, 2004.
66. Zhao B, Bowden RA, Stavchansky SA, and Bowman PD. Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays. Am J Physiol Cell Physiol 281: C1587-C1595, 2001.