Cognitive dysfunction in schizophrenia: Glutamatergic hypoactivity and dopaminergic failure

Drug Discovery Today: Disease Mechanisms

Volumn 1, Issue 4, 2004, Pages 435-439

  Holcomb, Henry H ^a   Rowland, Laura M ^a   Tagamets, Malle A ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; AMPA RECEPTOR; CX 717; CX717; CYCLOSERINE; DEXTRO SERINE; EGLUMETAD; GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; ORGANON 2448; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANXIETY DISORDER; CLINICAL TRIAL; COGNITIVE DEFECT; DELUSION; DOPAMINERGIC ACTIVITY; FRONTAL CORTEX; HALLUCINATION; HUMAN; MENTAL DISEASE; MESENCEPHALON; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PYRAMIDAL NERVE CELL; REVIEW; SCHIZOPHRENIA; THOUGHT DISORDER; TREATMENT OUTCOME;

EID: 23744444855     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2004.11.017     Document Type: Review

References (45)

1. Konradi, C. et al. (2003) Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol. Ther. 97, 153-179
2. Farber, N.B. (2003) The NMDA receptor hypofunction model of psychosis. In Glutamate and Disorders of Cognition and Motivation (Moghaddam, B. and Wolf, M.E., eds), pp. 119-130, New York Academy of Sciences
3. Moghaddam, B. et al. (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17, 2921-2927
4. Rowland, L.M. et al. (2005) The effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4.0 T Proton MRS study. Am. J. Psychiatry
5. Krystal, J.H. et al. (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51, 199-214
6. Newcomer, J.W. et al. (1999) Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology 20, 106-118
7. Kremer, I. et al. (2004) Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia. Biol. Psychiatry 56, 441-446
8. Goff, D.C. et al. (1999) A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia. Biol. Psychiatry 45, 512-514
9. Otani, S. et al. (2003) Dopaminergic modulation of long-term synaptic plasticity in rat prefrontal neurons. Cereb. Cortex 13, 1251-1256
10. Peters, Y. et al. (2004) Prefrontal cortical up states are synchronized with ventral tegmental area activity. Synapse 52, 143-152
11. Elvevag, B. et al. (2000) Cognitive impairment in schizophrenia is the core of the disorder. Crit. Rev. Neurobiol. 14, 1-21
12. Svensson, T.H. (2000) Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs. Brain Res. Brain Res. Rev. 31, 320-329
13. Overton, PG. et al. (1997) Burst firing in midbrain dopaminergic neurons. Brain Res. Brain Res. Rev. 25, 312-334
14. Schultz, W. et al. (1997) A neural substrate of prediction and reward. Science 275, 1593-1599
15. Svensson, T.H. (2000) Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs. Brain Res. Brain Res. Rev. 31, 320-329
16. Servan-Schreiber, D. et al. (1990) A network model of catecholamine effects: gain, signal-to-noise ratio, and behavior. Science 249, 892-895
17. Bulsara, A.R. et al. (1996) Tuning in to noise. Phys. Today 39-45
18. Javitt, D.C. et al. (2000) Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern. Arch. Gen. Psychiatry 57, 1131-1137
19. Elvevag, B. et al. (2000) The use of cognitive context in schizophrenia: an investigation. Psychol. Med. 30, 885-897
20. Holcomb, H.H. et al. (2004) Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations. Psychiatry Res. 127, 207-216
21. Bruder, G. et al. (1998) The time course of visuospatial processing deficits in schizophrenia: an event-related brain potential study. J. Abnorm. Psychol. 107, 399-411
22. Butler, P.D. et al. (2001) Dysfunction of early-stage visual processing in schizophrenia. Am. J. Psychiatry 158, 1126-1133
23. Javitt, D.C. et al. (2000) Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern. Arch. Gen. Psychiatry 57, 1131-1137
24. Luce, R.D. (1986) Two-choice reaction times: basic ideas and data. In Response Times, Their Role in Inferring Elementary Mental Organization, pp. 205-272, Oxford University Press
25. Holcomb, H.H. et al. (2004) Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations. Psychiatry Res. 127, 207-216
26. Holcomb, H.H. et al. (2004) Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations. Psychiatry Res. 127, 207-216
27. Holroyd, C.B. et al. (2002) The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol. Rev. 109, 679-709
28. Mathalon, D.H. et al. (2002) Response-monitoring dysfunction in schizophrenia: an event-related brain potential study. J. Abnorm. Psychol. 111, 22-41
29. Falkenstein, M. et al. (2000) ERP components on reaction errors and their functional significance: a tutorial. Biol. Psychol. 51, 87-107
30. Gehring, W.J. et al. (2001) Functions of the medial frontal cortex in the processing of conflict and errors. J. Neurosci. 21, 9430-9437
31. Alain, C. et al. (2002) Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia. Cereb. Cortex 12, 840-846
32. Carter, C.S. et al. (2001) Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. Am. J. Psychiatry 158, 1423-1428
33. Dinse, H.R. et al. (2003) Pharmacological modulation of perceptual learning and associated cortical reorganization. Science 301, 91-94
34. Dolan, R.J. et al. (1995) Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature 378, 180-182
35. Cohen, J.D. et al. (1996) A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351, 1515-1527
36. Montague, P.R. et al. (1996) A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16, 1936-1947
37. Bao, S. et al. (2001) Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Nature 412, 79-83
38. Delanoy, R.L. et al. (1983) Amphetamine effects on long term potentiation in dentate granule cells. Pharmacol. Biochem. Behav. 18, 137-139
39. Gold, P.E. et al. (1984) Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine. Brain Res. 305, 103-107
40. Montague, P.R. et al. (1996) A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16, 1936-1947
41. Gurden, H. et al. (2000) Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal-prefrontal cortex synapses in vivo. J. Neurosci. 20, RC106
42. Coyle, J.T. (2004) The GABA-glutamate connection in schizophrenia: which is the proximate cause. Biochem. Pharmacol. 68, 1507-1514
43. Moghaddam, B. (2004) Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia. Psychopharmacology (Berlin) 174, 39-44
44. Homayoun, H. et al. (2004) Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology 29, 1259-1269
45. Coyle, J.T. (2004) The GABA-glutamate connection in schizophrenia: which is the proximate cause? Biochem. Pharmacol. 68, 1507-1514