Recombinant human relaxin (rhRLX) modifies systemic arterial properties in conscious rats irrespective of gender, but in a biphasic fashion

Annals of the New York Academy of Sciences

Volumn 1041, Issue , 2005, Pages 155-162

  Debrah, Dan O ^a   Conrad, Kirk P ^a,b   Novak, Jackie ^b   Danielson, Lee A ^c   Shroff, Sanjeev G ^a  

^a University of Pittsburgh   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac output; Relaxin; Systemic arterial load

Indexed keywords

DRUG VEHICLE; RECOMBINANT HUMAN RELAXIN; RELAXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY COMPLIANCE; CHRONIC DRUG ADMINISTRATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HEART HEMODYNAMICS; HEART OUTPUT; MALE; NONHUMAN; RAT; SECOND TRIMESTER PREGNANCY; SEX DIFFERENCE;

EID: 23644462866     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1282.023     Document Type: Conference Paper

References (20)

1. POPPAS, A., S. SHROFF, C. KORCARZ, et al. 1997. Serial assessment of the cardiovascular system in normal pregnancy. Role of arterial compliance and pulsatile arterial load. Circulation 95: 2407-2415.
2. ROBSON, S.C., S. HUNTER, R.J. BOYS & W. DUNLOP. 1989. Serial study of factors influencing changes in cardiac output during normal human pregnancy. Am. J. Physiol. 256 (4 Pt 2): H1060-1065.
3. CONRAD, K. & J. NOVAK. 2004. The emerging role of relaxin in renal and cardiovascular function. Am. J. Physiol. 287: R250-R261.
4. DANIELSON, L., O. SHERWOOD & K. CONRAD. 1999. Relaxin is a potent renal vasodilator in conscious rats. J. Clin. Invest. 103: 525-533.
5. JEYABALAN, A., J. NOVAK, L. DANIELSON, et al. 2003. Essential role for vascular gelatinase in relaxin-induced renal vasodilation, hyperfiltration and reduced myogenic reactivity of small arteries. Circ. Res. 93: 1249-1257.
6. NOVAK, J., R. RAMIREZ, R. GANDLEY, et al. 2002. Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats. Am. J. Physiol. 283: R349-R355.
7. DANIELSON, L., L. KERCHNER & K. CONRAD. 2000. Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats. Am. J. Physiol. 279: R1298-R1304.
8. DANIELSON, L. & K. CONRAD. 2003. Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats. J. Appl. Physiol. 95: 1509-1514.
9. SHERWOOD, O. 2004. Relaxin's physiological roles and other diverse actions. Endocrinol. Rev. 25: 205-234.
10. GILSON, G., M. MOSHER & K. CONRAD. 1992. Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats. Am. J. Physiol. 32: H1911-H1918.
11. SLANGEN, B., M. OUT & L. PEETERS. 1996. Hemodynamic changes in early pregnancy in chronically instrumented, conscious rats. Am. J. Physiol. 270: H1779-1784.
12. CONRAD, K.P., D.O. DEBRAH, J. NOVAK, et al. 2004. Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats. Endocrinology 145: 3289-3296.
13. DEBRAH, D.O., K.P. CONRAD, L.A. DANIELSON & S.O. SHROFF. 2004. Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: gender dependency and dose response. J. Appl. Physiol. 98: 1013-1020.
14. OSBORN, J., JR., B. BARBER, E. QUILLEN, Jr., et al. 1986. Chronic measurement of cardiac output in unanesthetized rats using miniature thermocouples. Am. J. Physiol. 251: H1365-H1372.
15. MILLS, P., D. HUETTEMAN, B. BROCKWAY, et al. 2000. A new method for measurement of blood pressure, heart rate, and activity in the mouse by radiotelemetry. J. Appl. Physiol. 88: 1537-1544.
16. LIU, Z., K. BRIN & F.C.P. YIN. 1986. Estimation of total arterial compliance: an improved method and evaluation of current methods. Am. J. Physiol. 251: H588-H600.
17. CHEMLA, D., J. HEBERT, C. COIRAULT, et al. 1998. Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans. Am. J. Physiol. 274: H500-H505.
18. HASAN, K.M., I.T. MANYONDA, F.S. NG, et al. 2002. Skin capillary density changes in normal pregnancy and pre-eclampsia. Hypertension 20: 2439-2443.
19. KAKOURIS, H., L. EDDIE & R. SUMMERS. 1992. Cardiac effects of relaxin in rats. Lancet 339: 1076-1078.
20. NOVAK, J., L. DANIELSON, L. KERCHNER, et al. 2001. Relaxin is essential for renal vasodilation during pregnancy in conscious rats. J. Clin. Invest. 107: 1469-1475.