Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids

International Immunopharmacology

Volumn 5, Issue 12, 2005, Pages 1713-1722

  Hutchinson, Mark R ^a,b   Somogyi, Andrew A ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cell proliferation; Immune system; Isomer; Methadone; Non 4,5 epoxymorphinans; Opioids; Stereoselectivity

Indexed keywords

ALFENTANIL; DEXTROMETHORPHAN; DEXTRORPHAN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; FENTANYL; LEVORPHANOL; METHADONE; MORPHINAN DERIVATIVE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONAZINE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE DERIVATIVE; REMIFENTANIL;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EVALUATION; IC 50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STEREOCHEMISTRY;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; LYMPHOCYTES; MALE; MICE; MICE, INBRED BALB C; MORPHINANS; NARCOTICS; OPIOID PEPTIDES; SPLEEN;

EID: 23644452466     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2005.05.006     Document Type: Article

References (47)

1. J. Wybran, T. Appelboom, J.P. Famaey, and A. Govaerts Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes J Immunol 123 3 1979 1068 1070
2. P. Sacerdote, B. Manfredi, P. Mantegazza, and A.E. Panerai Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study Br J Pharmacol 121 4 1997 834 840
3. M.R. Hutchinson, and A.A. Somogyi Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation Eur J Pharmacol 494 2-3 2004 251 262
4. N.E.S. Sibinga, and A. Goldstein Opioid peptides and opioid receptors in cells of the immune system Annu Rev Immunol 6 1988 219 249
5. A.F. Casy, and R.T. Parfitt Opioid analgesics: chemistry and receptors 1986 Plenum Press New York
6. R.V. House, P.T. Thomas, J.T. Kozak, and H.N. Bhargava Suppression of immune function by non-peptidic delta opioid receptor antagonists Neurosci Lett 198 2 1995 119 122
7. R.V. House, P.T. Thomas, and H.N. Bhargava In vitro evaluation of fentanyl and meperidine for immunomodulatory activity Immunol Lett 46 1-2 1995 117 124
8. R.V. House, P.T. Thomas, and H.N. Bhargava A comparative study of immunomodulation produced by in vitro exposure to delta opioid receptor agonist peptides Peptides 17 1 1996 75 81
9. R.V. House, P.T. Thomas, and H.N. Bhargava Immunotoxicology of opioids, inhalants, and other drugs of abuse NIDA Res Monogr 173 1997 175 200
10. R.V. House, P.T. Thomas, and H.N. Bhargava In vitro exposure to peptidic delta opioid receptor antagonists results in limited immunosuppression Neuropeptides 31 1 1997 89 93
11. P.T. Thomas, H.N. Bhargava, and R.V. House Immunomodulatory effects of in vitro exposure to morphine and its metabolites Pharmacology 50 1 1995 51 62
12. P.T. Thomas, R.V. House, and H.N. Bhargava Direct cellular immunomodulation produced by diacetylmorphine (heroin) or methadone Gen Pharmacol 26 1 1995 123 130
13. S. Roy, B.L. Ge, S. Ramakrishnan, N.M. Lee, and H.H. Loh [3H]morphine binding is enhanced by IL-1-stimulated thymocyte proliferation FEBS Lett 287 1-2 1991 93 96
14. S. Roy, K.J. Cain, R.B. Chapin, R.G. Charboneau, and R.A. Barke Morphine modulates NF kappa B activation in macrophages Biochem Biophys Res Commun 245 2 1998 392 396
15. J.J. Jessop, and M.S. Taplits Effect of high doses of morphine on Con-A induced lymphokine production in vitro Immunopharmacology 22 3 1991 175 184
16. J.J. Madden, W.L. Whaley, D. Ketelsen, and R.M. Donahoe The morphine-binding site on human activated T-cells is not related to the mu opioid receptor Drug Alcohol Depend 62 2 2001 131 139
17. H. Ovadia, P. Nitsan, and O. Abramsky Characterization of opiate binding sites on membranes of rat lymphocytes J Neuroimmunol 21 2-3 1989 93 102
18. J.M. Bidlack, D.B. Joseph, and D.M.P. Lawrence Kappa opioid receptors on three related thymoma cell lines Adv Exp Med Biol 373 1995 23 27
19. S.A. Ahmed, R.M. Gogal Jr., and J.E. Walsh A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay J Immunol Methods 170 2 1994 211 224
20. C. Gaveriaux-Ruff, D. Filliol, F. Simonin, H.W. Matthes, and B.L. Kieffer Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity J Pharmacol Exp Ther 298 3 2001 1193 1198
21. M. Ochshorn, D.M. Novick, and M.J. Kreek In vitro studies of the effect of methadone on natural killer cell activity Isr J Med Sci 26 8 1990 421 425
22. V.K. Singh Suppressive effects of methadone on human blood lymphocytes Immunol Lett 2 1980 177
23. D.J. Carr, R.T. Radulescu, B.R. deCosta, K.C. Rice, and J.E. Blalock Differential effect of opioids on immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen Life Sci 47 12 1990 1059 1069
24. M.H. Makman, K. Dobrenis, S. Downie, W.D. Lyman, and B. Dvorkin Presence of opiate alkaloid-selective mu3 receptors in cultured astrocytes and in brain and retina Adv Exp Med Biol 402 1996 23 28
25. C. Pignatti, I. Stanic, C. Stefanelli, B. Tantini, C. Rossoni, and F. Flamigni Modulation of the induction of ornithine decarboxylase by some opioid receptor agonists in immune cells and cardiomyocytes Mol Cell Biochem 185 1-2 1998 47 53
26. R.T. Radulescu, B.R. DeCosta, A.E. Jacobson, K.C. Rice, J.E. Blalock, and D.J. Carr Biochemical and functional characterisation of a mu-opioid receptor binding site on cells of the immune system Progress in NeuroEndocrinImmunology 4 3 1991 166 179
27. J. Kowalski Immunomodulatory action of class mu, delta and kappa opioid receptor agonists in mice Neuropeptides 32 4 1998 301 306
28. T.K. Eisenstein, D.D. Taub, W.A. Alder, and T.J. Rogers The effect of morphine and DAGO on the proliferative response of murine splenocytes Adv Exp Med Biol 288 1991 203 211
29. F.H. Hucklebridge, B.N. Hudspith, P.M. Lydyard, and J. Brostoff Stimulation of human peripheral lymphocytes by methionine enkephalin and delta-selective opioid analogues Immunopharmacology 19 2 1990 87 91
30. E.L. Morgan Regulation of human B lymphocyte activation by opioid peptide hormones. Inhibition of IgG production by opioid receptor class (mu-, kappa-, and delta-) selective agonists J Neuroimmunol 65 1 1996 21 30
31. A. Hole Depression of monocytes and lymphocytes by stress-related humoral factors and anaesthetic-related drugs Acta Anaesthesiol Scand 28 3 1984 280 286
32. N.A. Shahabi, and B.M. Sharp Delta opioid agonists inhibit proliferation of highly purified murine CD4+ and CD8+T cells Adv Exp Med Biol 373 1995 29 36
33. T.J. Rogers, D.D. Taub, T.K. Eisenstein, E.B. Geller, and M.W. Adler Immunomodulatory activity of kappa-, mu-, and delta-selective opioid compounds NIDA Res Monogr 105 1991 82 88
34. M. Sedqi, S. Roy, S. Ramakrishnan, and H.H. Loh Expression cloning of a full-length cDNA encoding delta opioid receptor from mouse thymocytes J Neuroimmunol 65 2 1996 167 170
35. C. Gaveriaux, J. Peluso, F. Simonin, J. Laforet, and B. Kieffer Identification of kappa- and delta-opioid receptor transcripts in immune cells FEBS Lett 369 2-3 1995 272 276
36. B. Miller Delta opioid receptor expression is induced by concanavalin A in CD4+ T cells J Immunol 157 12 1996 5324 5328
37. M.S. Pampusch, M.A. Osinski, D.R. Brown, and M.P. Murtaugh The porcine mu opioid receptor: molecular cloning and mRNA distribution in lymphoid tissues J Neuroimmunol 90 2 1998 192 198
38. B.M. Sharp, N. Shahabi, D. McKean, M.D. Li, and K. McAllen Detection of basal levels and induction of delta opioid receptor mRNA in murine splenocytes J Neuroimmunol 78 1-2 1997 198 202
39. M.D. Li, K. McAllen, and B.M. Sharp Regulation of delta opioid receptor expression by anti-CD3-epsilon, PMA, and ionomycin in murine splenocytes and T cells J Leukoc Biol 65 5 1999 707 714
40. L. McCarthy, M. Wetzel, J.K. Sliker, T.K. Eisenstein, and T.J. Rogers Opioids, opioid receptors, and the immune response Drug Alcohol Depend 62 2 2001 111 123
41. J.J. Madden, W.L. Whaley, and D. Ketelsen Opiate binding sites in the cellular immune system: expression and regulation J Neuroimmunol 83 1-2 1998 57 62
42. E.E. Codd, R.P. Shank, J.J. Schupsky, and R.B. Raffa Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception J Pharmacol Exp Ther 274 3 1995 1263 1270
43. Z.R. Chen, R.J. Irvine, A.A. Somogyi, and F. Bochner Mu receptor binding of some commonly used opioids and their metabolites Life Sci 48 22 1991 2165 2171
44. M. Yeadon, and I. Kitchen Comparative binding of mu and delta selective ligands in whole brain and pons/medulla homogenates from rat: affinity profiles of fentanyl derivatives Neuropharmacology 27 4 1988 345 348
45. G. Bonner, F. Meng, and H. Akil Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop Eur J Pharmacol 403 1-2 2000 37 44
46. T.G. Metzger, M.G. Paterlini, D.M. Ferguson, and P.S. Portoghese Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus J Med Chem 44 6 2001 857 862
47. E.H. Cox, M.W. Langemeijer, J.M. Gubbens-Stibbe, K.T. Muir, and M. Danhof The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model Anesthesiology 90 2 1999 535 544