Analyses of serum levels of type 1, type 2 and type 3 cytokines reveal multiple abnormalities in lupus-prone (NZB x NZW) F1 mice

APLAR Journal of Rheumatology

Volumn 7, Issue 1, 2004, Pages 3-10

  De Albuquerque, Deijanira A ^a   Ebling, Fanny M ^b   Lienesch, Douglas W ^a   Singh, Ram Raj ^a   Hahn, Bevra H ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoantibodies; Autoimmunity; Cytokines; Lupus; NZB NZW F1 mice

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CIRCULATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DISEASE PREDISPOSITION; FEMALE; IN VIVO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MEASUREMENT; MOUSE; MOUSE STRAIN; NEW ZEALAND BLACK MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 23644448297     PISSN: 02190494     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1479-8077.2004.00061.x     Document Type: Article

References (45)

1. Hahn BH (1998) Antibodies to DNA. N Engl J Med 338, 1359-68.
2. Davidson A, Diamond B (2001) Autoimmune diseases. N Engl J Med 345, 340-50.
3. Spronk PE, Horst G, Var Der Gun BT, Limburg PC, Kallenberg CG (1996) Anti-dsDNA production coincides with concurrent B and T cell activation during development of active disease in systemic lupus erythematosus (SLE). Clin Exp Immunol 104, 446-53.
4. Ando DG, Sercarz EE, Hahn BH (1987) Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 SLE model. J Immunol 138, 3185-90.
5. Datta SK, Patel H, Berry D (1987) Induction of a cationic shift in IgG anti-DNA antibodies - Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J Exp Med 165, 1252-68.
6. - T cells from lupus-prone mice avoid antigen-specific tolerance induction in vivo. J Immunol 170, 741-8.
7. Kotzin BL (1996) Systemic lupus erythematosus. Cell 85, 303-6.
8. Andrews BS, Eisenberg RA, Theofilopoulos AN et al. (1978) Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148, 1198-215.
9. Singh RR, Kumar V, Ebling FM et al. (1995) T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J Exp Med 181, 2017-27.
10. Singh RR, Ebling FM, Albuquerque DA et al. (2002) Induction of autoantibody production is limited in nonautoimmune mice. J Immunol 169, 587-94.
11. Lin LC, Chen YC, Chou CC, Hsieh KH, Chiang BL (1995) Dysregulation of helper cell cytokines in autoimmune prone NZB x NZW F1 mice. Scand J Immunol 42, 466-72.
12. Shirai A, Conover J, Klinman DM (1995) Increased activation and altered ratio of interferon-gamma: interleukin-4 secreting cells in MRL-lpr/lpr mice. Autoimmunity 21, 107-16.
13. McMurray RW, Hoffman RW, Nelson W, Walker SE (1997) Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus - analyses of strain, gender, and age effects. Clin Immunol Immunopathol 84, 260-8.
14. Funauchi M, Ikoma S, Enomoto H, Horiuchi A (1998) Decreased Th1-like and increased Th2-like cells in systemic lupus erythematosus. Scand J Rheumatol 27, 219-24.
15. Morimoto S, Tokano Y, Kaneko H, Nozawa K, Amano H, Hashimoto H (2001) The increased interleukin-13 in patients with systemic lupus erythematosus: relations to other Th1-, Th-related cytokines and clinical findings. Autoimmunity 34, 19-25.
16. Ohnishi K, Ebling FM, Mitchell B, Singh RR, Hahn BH, Tsao BP (1994) Comparison of pathogenic and nonpathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int Immuno 6, 817-30.
17. Hahn BH, Singh RR, Wong WK, Tsao BP, Bulpitt K, Ebling FM (2001) Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus. Arthritis Rheum 44, 432-41.
18. Finkelman FD, Morris SC (1999) Development of an assay to measure in vivo cytokine production in the mouse. Int Immunol 11, 1811-8.
19. Singh RR, Saxena V, Zang S et al. (2003) Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 170, 4818-25.
20. Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev 127, 5-24.
21. Spitalny G, Havell E (1984) Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J Exp Med 159, 1560-5.
22. Abe M, Harpel IG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB (1994) An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 216, 276-84.
23. Singh RR (2003) Editorial: IL-4 and many roads to lupus-like autoimmunity. Clin Immunol 108, 73-9.
24. Prud'homme GJ, Piccirillo CA (2000) The inhibitory effects of transforming growth factor-beta-1 (TGF-β1) in autoimmune disease. J Autoimmun 14, 23-42.
25. Bommireddy R, Saxena V, Ormsby I et al. (2003) Transforming Growth Factor β1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J Immunol 170, 4612-22.
26. Gray D, Hirokawa M, Ohtsuka K, Horwitz DA (1998) Generation of an inhibitory circuit involving CD8+ T cells, IL-2 and NK cell-derived TGF-beta: contrasting effects of anti-CD2 and anti-CD3. J Immunol 160, 2248-54.
27. Theofilopoulos AN, Lawson BR (1999) Tumor necrosis factor and other cytokines in lupus. Ann Rheum Dis 58, 149-55.
28. Pollard KM, Hultman P, Kono DH (2003) Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity. Ann NY Acad Sci 987, 236-9.
29. Ozmen L, Roman D, Fountoulakis M, Schmid G, Ryffel B, Garotta G (1995) Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis. Eur J Immunol 25, 6-12.
30. Lawson BR, Prud'Homme GJ, Chang Y et al. (2000) Treatment of murine lupus with cDNA encoding IFN-gamma R/Fc. J Clin Invest 106, 207-15.
31. Piccirillo CA, Prud'homme GJ (2003) Immune modulation by plasmid DNA-mediated cytokine gene transfer. Curr Pharm Des 9, 83-94.
32. Haas C, Ryffel B, Le Hir M (1998) IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW) F1 mice. J Immunol 160, 3713-8.
33. Seery JP (2000) IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus? Arthritis Res 2, 437-40.
34. Baechler EC, Batliwalla FM, Karypis G (2003) Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 100, 2610-5.
35. YeS, Pang H, Gu YY et al. (2003) Protein interaction for an interferon-inducible systemic lupus associated gene, IFIT1. Rheumatology (Oxford) 42, 1155-63.
36. Raz E, Dudler J, Lotz M (1995) Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 4, 286-9.
37. Yamamoto K, Loskutoff DJ (2000) Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis. Laboratory Invest 80, 1561-70.
38. Singh RR, Lienesch DW, Saxena V (2003) Mechanisms of target organ damage in lupus: Role of type 2 cytokines and TGFβ. Clin Immunolsupplement 1, S52.
39. Brennan DC, Yui MA, Wuthrich RP, Kelley VR (1989) Tumor necrosis factor and IL-1 in New Zealand Black/ White mice. Enhanced gene expression and acceleration of renal injury. J Immunol 143, 3470-5.
40. Schwarting A, Wada T, Kinoshita K, Tesch G, Kelley VR (1998) IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas (lpr) mice. J Immunol 161, 494-503.
41. Schwarting A, Texch G, Kinoshita K, Maron R, Weiner HL, Kelley VR (1999) IL-12 drives IFN-gamma-dependent autoimmune kidney disease in MRL-Fas (lpr) mice. J Immunol 163, 6884-91.
42. Faust J, Menke J, Kriegsmann J (2002) Correlation of renal tubular epithelial- cell-derived interleukin-18 upregulation with disease activity in MRL-Faslpr mice with autoimmune lupus nephritis. Arthritis Rheum 46, 3083-95.
43. Schiffer L, Sinha J, Wang X et al. (2003) Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. J Immunol 171, 489-97.
44. Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA (2001) A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 166, 7282-9.
45. Zheng SG, Gray JD, Ohtsuka K, Yamagiwa S, Horwitz DA (2002) Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J Immunol 169, 4183-9.