Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance

Journal of Clinical Investigation

Volumn 115, Issue 8, 2005, Pages 2209-2213

  Drolet, Benoit ^a   Simard, Chantale ^a   Mizoue, Laura ^a   Roden, Dan M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; POTASSIUM CHANNEL; QUINIDINE; VOLTAGE GATED POTASSIUM CHANNEL;

ALGORITHM; ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA STRUCTURE; DRUG BINDING SITE; DRUG RESISTANCE; DRUG SENSITIVITY; GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; KCNA5 GENE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; DRUG RESISTANCE; ENZYME INHIBITORS; HUMANS; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; POLYMORPHISM, GENETIC; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, SECONDARY; QUINIDINE;

EID: 23644447047     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI23741     Document Type: Article

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