Synthesis and structure-activity relationship of imidazo[1,2-a] benzimidazoles as corticotropin-releasing factor 1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 18, 2005, Pages 4029-4032

  Han, Xiaojun ^a   Pin, Sokhom S ^a   Burris, Kevin ^a,b   Fung, Lawrence K ^a,c   Huang, Stella ^a   Taber, Matthew T ^a   Zhang, Jie ^a,d   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Palatin Technologies   (United States)

^c NEUROGEN CORPORATION   (United States)

^d SANOFI   (France)

Author keywords

Antagonists; Corticotropin releasing factor 1; Pharmacokinetic properties; SAR

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; INDENE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23644444607     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.028     Document Type: Article

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