SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: A novel class of cytotoxic agents for prostate cancer

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 18, 2005, Pages 4010-4013

  Gududuru, Veeresa ^a   Hurh, Eunju ^b   Sullivan, Joshua ^a   Dalton, James T ^b   Miller, Duane D ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

GPCRs; Prostate cancer; SAR; Synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; TIMONACIC DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CLASSIFICATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROSTATE CARCINOMA; SENSITIVITY ANALYSIS; STRUCTURE ACTIVITY RELATION; TRANSITIONAL CELL CARCINOMA;

AMIDES; ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL LINE; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23644435761     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.032     Document Type: Article

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18. 3) δ: 13.5, 22.1, 25.5, 26.4, 27.2, 27.7, 28.7, 28.8, 28.9, 29.0, 29.1, 31.3, 38.4, 38.7, 39.9, 67.2, 67.9, 73.3, 74.2, 111.8, 111.9, 127.6, 127.9, 168.0, 169.6; MS (ESI) m/z 533 [M+1].