In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2787-2790

  Yamamoto, Tatsuhiro ^a   Ikuta, Kenjiro ^a   Oi, Keiji ^b   Abe, Kohtaro ^b   Uwatoku, Toyokazu ^b   Hyodo, Fuminori ^a   Murata, Masaharu ^a   Shigetani, Noboru ^c   Yoshimitsu, Kengo ^b   Shimokawa, Hiroaki ^b   Utsumi, Hideo ^a   Katayama, Yoshiki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cardiovascular disease; MRI; MRI contrast agent; Vascular endothelial injury

Indexed keywords

CONTRAST MEDIUM; GADOLINIUM PENTETATE DERIVATIVE;

ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; CAROTID ARTERY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENTIATION; DRUG SYNTHESIS; ELECTROCHEMICAL DETECTION; ENDOTHELIUM INJURY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; VASCULAR DISEASE; VASCULAR ENDOTHELIAL INJURY; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; BALLOON DILATATION; CAROTID ARTERY INJURIES; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENDOTHELIUM, VASCULAR; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING; RATS; SWINE; TISSUE DISTRIBUTION; VASCULAR DISEASES;

SUIDAE;

EID: 2342643581     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.066     Document Type: Article

References (14)

1. Caravan P., Ellison J.J., McMurry T.J., Lauffer R.B. Chem. Rev. 99:1999;2293
2. Piguet C., Bunzli J.C.G. Chem. Soc. Rev. 28:1999;347
3. Sipkins D.A., Cheresh D.A., Kazemi M.R., Nevin L.M., Bednarski M.D., Li K.C. Nat. Med. 4:1998;623
4. Anderson S.A., Rader R.K., Westlin W.F., Null C., Jackson D., Lanza G.M., Wickline S.A., Kotyk J.J. Magn. Reson. Med. 44:2000;433
5. Sipkins D.A., Gijbels K., Tropper F.D., Bednarski M., Li K.C., Steinman L. J. Neuroimmunol. 104:2000;1
6. Yu X., Song S.K., Chen J., Scott M.J., Fuhrhop R.J., Hall C.S., Gaffney P.J., Wickline S.A., Lanza G.M. Magn. Reson. Med. 44:2000;867
7. Herborn C.U., Waldschuetz R., Lauenstein T.C., Goyen M., Lauffer R.B., Moeroey T., Debatin J.F., Ruehm S.G. Invest. Radiol. 37:2002;464
8. Ross R.N. Engl. J. Med. 340:1999;115
9. Bazzoni G., Martinez E.O., Dejana E. Trends Cardiovasc. Med. 9:1999;147
10. Yamamoto T., Ikuta K., Oi K., Abe K., Uwatoku T., Murata M., Shigetani N., Yoshimitsu K., Shimokawa H., Katayama Y. Anal. Sci. 20:2004;5
11. 1H NMR and elemental analysis
12. Porcine serum was prepared as follows. Extracted porcine blood was centrifuged at 3000 rpm for 10 min to remove hemocyte. The concentrations of serum proteins obtained as the supernatant were determined to be 55 mg/mL (albumin: 33 mg/mL) by entrusting them to an outsourcer
13. Uwatoku T., Shimokawa H., Abe K., Matsumoto Y., Hattori T., Oi K., Matsuda T., Kataoka K., Takeshita A. Circ. Res. 92:2003;e62
14. Tsopelas C., Sutton R. J. Nucl. Med. 43:2002;1377