Carbon monoxide is an endogenous hyperpolarizing factor in the gastrointestinal tract

Neurogastroenterology and Motility

Volumn 16, Issue SUPPL. 1, 2004, Pages 81-85

  Szurszewski, J H ^a,b   Farrugia, G ^b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Carbon monoxide; Circular smooth muscle; Haem oxygenase; Interstitial cells of Cajal; Voltage gradients

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARBON MONOXIDE; HEME OXYGENASE 2; INWARDLY RECTIFYING POTASSIUM CHANNEL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; STEM CELL FACTOR RECEPTOR; TETRODOTOXIN;

CELL ACTIVITY; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL POPULATION; CONFERENCE PAPER; ENZYME ACTIVITY; GANGLION; GASTROINTESTINAL TRACT; GENE DELETION; GENE MUTATION; HUMAN; HYPERPOLARIZATION; INTERSTITIAL CELL OF CAJAL; INTESTINE INNERVATION; MEMBRANE STEADY POTENTIAL; MOTONEURON; MYENTERIC PLEXUS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STOMACH ANTRUM; STOMACH FUNDUS;

ANIMALS; CARBON MONOXIDE; DIGESTIVE SYSTEM; ENTERIC NERVOUS SYSTEM; GASTROINTESTINAL MOTILITY; HUMANS; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SMOOTH;

EID: 2342633734     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1743-3150.2004.00480.x     Document Type: Conference Paper

References (43)

1. Coburn RF. Endogenous carbon monoxide production. N Engl J Med 1970; 282: 207-9.
2. Ny L, Alm P, Larsson B, Andersson KE. Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts. J Anton Nezv Syst 1997; 65: 49-56.
3. Zakhary R, Gaine SP, Dinerman JL, Ruat M, Flavahan NA, Snyder SH. Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc Natl Acad Sci USA 1996; 93: 795-8.
4. + pump as a site of action for carbon monoxide and glutamate: a mechanism for long-term modulation of cellular activity. Neuron 1995; 14: 781-94.
5. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517-54.
6. Furchgott RF, Jothianandan D. Endothelium-dependent and -independent vasodilation involving cyclic GMF: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels 1991; 28: 52-61.
7. Wang R, Wang Z, Wu L. Carbon monoxide-induced vaso-relaxation and the underlying mechanisms. Br J Pharmacol 1997; 121: 927-34.
8. Wang R, Wu L, Wang Z. The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells. Pflugers Azch 1997; 434: 285-91.
9. Farrugia G, Miller SM, Rich A et al. Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum. Am J Physiol 1998; 274: G350-8.
10. Farrugia G, Irons WA, Rae JL, Sarr MG, Szurszewski JH. Activation of whole cell currents in isolated human jejunal circular smooth muscle cells by carbon monoxide. Am J Physiol 1993; 264: G1184-9.
11. Battish R, Cao GY, Lynn RB, Chakder S, Rattan S. Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase. Am J Physiol 2000, 278: G148-55.
12. Farrugia G, Sha L, Lin X et al. A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract. Proc Natl Acad Sci USA 2003; 100: 8567-70.
13. Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, Snyder SH. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proc Natl Acad Sci USA 1997; 94: 14848-53.
14. Farrugia G, Szurszewski JH. Heme oxygenase, carbon monoxide, and interstitial cells of Cajal. Microsc Res Tech 1999; 47: 321-4.
15. Xue L, Farrugia G, Miller SM, Ferris CD, Snyder SH, Szurszewski JH. Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes. Proc Natl Acad Sci USA 2000; 97: 1851-5.
16. Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, Szurszewski JH. Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine. Gastzoentezology 1998; 114: 239-44.
17. Miller SM, Reed D, Sarr MG, Farrugia G, Szurszewski JH. Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase. Neurogastroentezol Motility 2001; 13: 121-31.
18. Ny L, Alm P, Ekstrom P, Larsson B, Grundemar L, Andersson KE. Localization and activity of haem oxygenase and functional effects of carbon monoxide in the feline lower oesophageal sphincter. Br J Pharmacol 1996; 118: 392-9.
19. Porcher C, Orsoni P, Berdah S, Monges G, Mazet B. Distribution of heme oxygenase 2 in nerves and c-kit (+) interstitial cells in human stomach. Histochem Cell Biol 1999; 112: 317-22.
20. Donat ME, Wong K, Staines WA, Krantis A. Heme oxygenase immunoreactive neurons in the rat intestine and their relationship to nitrergic neurons. J Auton Nerv Syst 1999; 77: 4-12.
21. Rattan S, Chakder S. Influence of heme oxygenase inhibitors on the basal tissue enzymatic activity and smooth muscle relaxation of internal anal sphincter. J Pharmacol Exp Ther 2000; 294: 1009-16.
22. Chakder S, Cao GY, Lynn RB, Rattan S. Heme orygenase activity in the internal anal sphincter: effects of nonadrenergic, noncholinergic nerve stimulation. Gastroenterology 2000; 118: 477-86.
23. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995; 373: 347-9.
24. Burns AJ, Lomax AE, Torihashi S, Sanders KM, Ward SM. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci USA 1996; 93: 12008-13.
25. Szurszewski JH. Electrical basis for gastrointestinal motility. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1987: 383-422.
26. Bauer AJ, Sanders KM. Gradient in excitation-contraction coupling in canine gastric antral circular muscle. J Physiol 1985; 369: 283-94.
27. Bauer AJ, Sanders KM. Passive and active membrane properties of canine gastric antral circular muscles. Am J Physiol 1986; 251: C268-C273.
28. Bauer AJ, Reed JB, Sanders KM. Slow wave heterogeneity within the circular muscle of the canine gastric antrum. J Physiol 1985; 366: 221-32.
29. Hara Y, Kubota M, Szurszewski JH. Electrophysiology of smooth muscle of the small intestine of some mammals. J Physiol 1986; 372: 501-20.
30. Sanders KM, Smith TK. Electrophysiology of colonic smooth muscle. In: Schultz SG, Wood J D, eds. The Gastrointestinal System, Section 6, Vol. 1. New York: Oxford University Press, 1989: 251-71.
31. Ward SM, Beckett EA, Wang X, Baker F, Khoyi M, Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000; 20: 1393-403.
32. Stark ME, Bauer AJ, Sarr MG, Szurszewski JH. Nitric oxide mediates inhibitory nerve input in human and canine jejunum. Gastzoenterology 1993; 104: 398-409.
33. Koh SD, Ward SM, Dick GM et al. Contribution of delayed rectifier potassium currents to the electrical activity of murine colonic smooth muscle. J Physiol 1999; 515: 475-87.
34. Farrugia G, Rae JL, Szurszewski JH. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. J Physiol 1993; 468: 297-310.
35. Burke EP, Sanders KM, Horowitz B. Sodium pump isozymes are differentially expressed in electrically dissimilar regions of colonic circular smooth muscle. Proc Natl Acad Sci USA 1991; 88: 2370-4.
36. Burke EP, Reed JB, Sanders KM. Role of sodium pump in membrane potential gradient of canine proximal colon. Am J Physiol 1988; 254: C475-C483.
37. Flynn ER, McManus CA, Bradley KK et al. Inward rectifier potassium conductance regulates membrane potential of canine colonic smooth muscle. J Physiol 1999; 518: 247-56.
38. Suematsu M, Ishimura Y. The heme oxygenase-carbon monoxide system: a regulator of hepatobiliary function. Hepatology 2000; 31: 3-6.
39. Hara Y, Szurszewski JH. Effect of potassium and acetylcholine on canine intestinal smooth muscle. J Physiol 1986; 372: 521-37.
40. Pachnis V, Durbec P, Taraviras S, Grigoriou M, Natarajan D III Role of the RET signal transduction pathway in development of the mammalian enteric nervous system. Am J Physiol 1998; 275: G183-6.
41. Ward SM, Burns AJ, Torihashi S, Hamey SC, Sanders KM. Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol 1995; 269: C1577-C1585.
42. Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 1996; 111: 492-515.
43. Ward SM, Burns AJ, Torihashi S, Sanders KM. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 1994; 480: 91-7.