Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia

British Journal of Haematology

Volumn 97, Issue 2, 1997, Pages 460-462

  Lanza, Carlo ^a,b   Volpe, Gisella ^a   Basso, Giuseppe ^b   Gottardi, Enrico ^a   Barisone, Elena ^b   Spinelli, Monica ^c   Ricotti, Emanuela ^b   Cilli, Vania ^a   Perfetto, Fatima ^a,b   Madon, Enrico ^b   Saglio, Giuseppe ^a,b  

^a SAN LUIGI GONZAGA HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

AML1; childhood ALL; prognosis; TEL; translocations

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; DIAGNOSTIC ACCURACY; FOLLOW UP; GENE TRANSLOCATION; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; RISK ASSESSMENT;

EID: 8244258017     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.312676.x     Document Type: Article

References (11)

1. Chambost, H., Michel, G., Thuret, I., Toiron, Y., Brunet, C., Capodano, A.M., Sainty, D., Maraninchi, D. & Gabert, J. (1996) TEL/AML1 transcript in childhood ALL: a new candidate for minimal residual disease study rather than a new prognostic factor? British Journal of Haematologgy, 93, (Suppl. II) 55-56.
2. Erickson, P., Gao, J., Chang, K.S., Look, T., Whisenant, E., Raimondi, S.C., Lasher, J., Rowley, J. & Drabkin, H. (1992) Identification of breakpoint in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript AML1/ETO with similarity to Drosophila segmentation gene. RUNT. Blood, 80, 1825-1831.
3. Golub, T.R., Barker, E.G., Bohlander, S.K., Hiebert, S.W., Ward, D.C., Bray-Ward, P., Morgan, E., Raimondi, S.C., Rowley, J.D. & Gilliland, D.G. (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 92, 4917-4921.
4. Golub, T.R., Barker, G.F., Lovett, M. & Gilliland, D.G., (1994) Fusion of PDGF receptor β to a novel ets-like gene. TEL, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell, 77, 307-316.
5. Myoshi, H., Shimuzu, K., Kozu, T., Maseki, N., Kaneko, Y. & Ohki, M. (1991) t(8:21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proceedings of the National Academy of Sciences of the United States of America, 8, 10431-10435.
6. Romana, S.P., Mauchauffe, M., Le Coniat, M., Chumakov, L, Le Paslier, D., Berger, R. & Bernard, O.A. (1995a) The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood, 85, 3662-3670.
7. Romana, S.P., Poirel, H., Leconiat, M., Flexor, M.-A., Mauchauffe, M., Jonveaux, P., Macintyre, E.A., Berger, R. & Bernard, O.A. (1995b) High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood, 86, 4263-4269.
8. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press. New York.
9. Shurtleff, S.A., Buijs, A., Behm, F.G., Rubnitz, J.E., Raimondi, S.C., Hancock, M.L., Chan, G.C.-F., Pui, C.H., Grosveld, G. & Downing, J.R. (1995) TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with excellent prognosis. Leukemia, 9, 1985-1989.
10. Stegmaier, K., Pendse, S., Barker, G.F., Bray-Ward, P., Ward, D.C., Montgomery, K.T., Krauter, K.S., Reynolds, C., Sklar, J., Donnely, M., Bohlander, S.K., Rowley, J.D., Sallan, S.E., Gilliland, D.G., & Golub, T.R. (1995) Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood, 86, 38-44.
11. Tanaka, T., Tanaka, K., Ogawa, S., Kurokawa, M., Mitani, S., Nishida, J., Yazaki, Y. & Hirai, H. (1995) An acute myeloid leukemia gene, AML1, regulates haemopoietic cells differentiation and transcriptional activation antagonistically by two spliced forms. EMBO Journal 14, 341-350.