Stem cell-mediated tolerance inducing strategies in organ transplantation

Kidney International

Volumn 65, Issue 5, 2004, Pages 1548-1550

  Fändrich, Fred ^a   Schulze, Maren ^a   Zehle, Gregor ^a   Lange, Hans ^a   Ungefroren, Hendrik ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Lymphocytes; Stem cells; Tolerance; Transplantation

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR; PREDNISONE; THYMOCYTE ANTIBODY;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANTIGEN PRESENTING CELL; CELL ACTIVATION; CELL DEATH; CELL ISOLATION; CELLULAR IMMUNITY; CHIMERA; CONFERENCE PAPER; DRUG EFFECT; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HLA TYPING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; LYMPH NODE IRRADIATION; LYMPHOCYTE FUNCTION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INDUCTION; RISK ASSESSMENT; STEM CELL; STEM CELL MOBILIZATION; STEM CELL TRANSPLANTATION; T LYMPHOCYTE;

EID: 2342618187     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.05408.x     Document Type: Conference Paper

References (27)

1. BILLINGHAM RE, BRENT L, MEDAWAR PB: Actively acquired tolerance of foreing cells. Nature 172:603-606 1953
2. DEY B, SYKES M, SPITZER TR: Outcomes of recipients of both bone marrow and solid organ transplants. A review. Medicine (Baltimore) 77:355, 1998
3. MILLAN MT, SHIZURU JA, HOFFMANN P, et al: Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation 73:1386-1391, 2002
4. BERMAN E, LITTLE C, GEE T, et al: Reasons that patients with acute myelogenous leukemia do not undergo allogeneic bone marrow transplantation. N Engl J Med 326:156-160, 1992
5. THOMAS ED, BUCKNER CD, CLIFT RA, et al: Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med 301:597-599, 1979
6. WEKERLE T, SYKES M: Mixed chimerism as an approach for the induction of transplantation tolerance. Transplantation 68:459-467, 1999
7. AVERSA F, TERENZI A, CAROTTI A, et al: T-cell depletion in allogeneic bone marrow transplantation for acute leukaemias. Bone Marrow Transplant 4 (Suppl 4): 69-72, 1989
8. AVERSA F, TABILIO A, TERENZI A, et al: Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 84:3948-3955, 1994
9. SLAVIN S, NAGLER A, NAPARSTEK E, et al: Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91:756-763, 1998
10. SYKES M, SHARABI Y, SACHS DH: Achieving alloengraftment without graft-versus-host disease: Approaches using mixed allogeneic bone marrow transplantation. Bone Marrow Transplant 3:379-386, 1988
11. SYKES M, SZOT GL, SWENSON KA, PEARSON DA: Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med 3:783-787, 1997
12. SYKES M, PREFFER F, MCAFEE S, et al: Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation [see comments]. Lancet 353:1755-1759, 1999
13. JORDAN MS, RILEY MP, VON BOEHMER H, CATON AJ: Anergy and suppression regulate CD4+ T cell responses to a self peptide. Eur J immunol 30:136-144, 2000
14. WEKERLE T, SAYEGH MH, CHANDRAKER A, et al: Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade. Transplant Proc 31:680, 1999
15. TAN P, ANASETTI C, HANSEN JA, et al: Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med 177:165-173, 1993
16. SAYEGH MH, AKALIN E, HANCOCK WW, et al: CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 181:1869-1874, 1995
17. + T cell tolerance and linked suppression. J Immunol 163:4805-4810, 1999
18. WELLS A, LI XC, LI Y, et al: Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 5:1303-1307, 1999
19. LI Y, LI XC, ZHENG XX, et al: Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 5:1298-1302, 1999
20. WEKERLE T, SAYEGH MH, HILL J et al: Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med 187:2037-2044, 1998
21. WEKERLE T, KURTZ J, SAYEGH MH, et al: Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol 166:2311-2316, 2001
22. VAN PARIJS L, ABBAS AK: Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science 280:243-248, 1998
23. KURTZ J, LIE A, GRIFFITH M, et al: Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. Am J Transpl 3:804-816, 2003
24. FÄNDRICH F, ZHOU X, SCHLEMMINGER M, et al: Future strategies for tolerance induction: A comparative study between hematopoietic stem cells and macrophages. Hum Immunol 63:805-812, 2002
25. FÄNDRICH F, LIN X, CHAI GX, et al: Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nat Med 8:171-178, 2002
26. BIANCHI DW: Current knowledge about fetal blood cells in the maternal circulation. J Perinat Med 26:175-185, 1998
27. HORI S, NOMURA T, SAKAGUCHI S: Control of regulatory T cell development by the transcription factor Foxp 3. Science 299:1057-1061, 2002