Acquired Robertsonian translocations are not rare events in acute leukemia and lymphoma

Cancer Genetics and Cytogenetics

Volumn 151, Issue 1, 2004, Pages 14-35

  Welborn, Jeanna ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACROCENTRIC CHROMOSOME; ACUTE LEUKEMIA; ADULT; AGED; ANEMIA; ARTICLE; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME MUTATION; CHRONIC MYELOMONOCYTIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; ISOCHROMOSOME; KARYOTYPE; LYMPHOMA; MALE; MYELODYSPLASIA; PRIORITY JOURNAL; ROBERTSONIAN CHROMOSOME TRANSLOCATION; STRUCTURAL CHROMOSOME ABERRATION;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; FEMALE; HUMANS; KARYOTYPING; LEUKEMIA; LYMPHOMA; MALE; MIDDLE AGED; TRANSLOCATION, GENETIC;

ROBERTSONIA;

EID: 2342590058     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2003.09.019     Document Type: Article

References (245)

1. Hsu L.Y.F. Prenatal diagnosis of chromosomal abnormalities through amniocentesis. Milunsky A. Genetic disorders of the fetus: diagnosis, prevention, and treatment. 4th edition:1998;179-248 The John Hopkins University Press, Baltimore
2. Hecht F., Morgan R., Hecht B.K. Robertsonian chromosome recombinants are rare in cancer. Cancer Genet Cytogenet. 35:1988;79-81
3. Robertson W.R.B. Taxonomic relationships shown in the chromosome of Tettigidae and Acrididae: v-shaped chromosomes and their significance in Acrididae, Locustidae, and Gryllidae chromosomes and variation. J Morphol. 27:1916;178-331
4. Gravholt C.H., Friedrich U., Caprani M., Jorgensen A.L. Breakpoints in Robertsonian translocations are localized to satellite III DNA by fluorescence in situ hybridization. Genomics. 14:1992;924-930
5. Henderson A.S., Warburton D., Atwood K.C. Location of ribosomal DNA in the human chromosome complement. Proc Natl Acad Sci USA. 69:1972;3394-3398
6. Spadari S., Di Lernia R., Simoni G., Pedrali-Noy G., De Carli L. Localization of ribosomal RNA genes on human acrocentric chromosomes. Mol Gen Genet. 127:1973;57-67
7. Choo K.H., Vissel B., Brown R., Filby R.G., Earle E. Homologous alpha satellite sequences on human acrocentric chromosomes with selectivity for chromosomes 13, 14 and 21: implications for recombination between nonhomologues and Robertsonian translocations. Nucleic Acids Res. 16:1989;1273-1284
8. Therman E., Susman B., Denniston C. The nonrandom participation of human acrocentric chromosomes in Robertsonian translocations. Ann Hum Genet. 53:1989;49-65
9. Page S.L., Shin J.C., Han J.Y., Choo K.H., Shaffer L.G. Breakpoint diversity illustrates distinct mechanisms for Robertsonian translocation formation. Hum Mol Genet. 5:1996;1279-1288
10. Natarajan A.T., Balajee A.S., Boei J.J., Darroudi F., Dominguez I., Hande M.P., Meijers M., Slijepcevic P., Vermeulen S., Xiao Y. Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization. Mutat Res. 372:1996;247-258
11. Wolff D.J., Schwartz S. Characterization of Robertsonian translocations by using fluorescence in situ hybridization. Am J Hum Genet. 50:1992;174-181
12. de la Chapelle A. How do human isochromosomes arise? Cancer Genet Cytogenet. 5:1982;173-179
13. Darlington C.D. Misdivision and the genetics of the centromere. J Genet. 37:1939;341-364
14. Fraccaro M., Ikkos D., Lindsten J., Luft R., Kaijser K. A new type of chromosomal abnormality in gonadal dysgenesis. Lancet. 2:1960;1144
15. Shaffer L.G., McCaskill C., Haller V., Brown J.A., Jackson-Cook C.K. Further characterization of 19 cases of rea(21q21q) and delineation as isochromosomes or Robertsonian translocations in Down syndrome. Am J Med Genet. 47:1993;1218-1222
16. Robinson W.P., Bernasconi F., Basaran S., Yuksel-Apak M., Neri G., Serville F., Balicek P., Haluza R., Farah L.M., Luleci G. A somatic origin of homologous Robertsonian translocations and isochromosomes. Am J Hum Genet. 54:1994;290-302
17. Mertens F., Johansson B., Mitelman F. Isochromosomes in neoplasia. Genes Chromosomes Cancer. 10:1994;221-230
18. Lobb D.S., Reeves B.R., Lawler S.D. Identification of isochromosome 17 in myeloid leukaemia. Lancet. 1:1972;849-850
19. Mitelman F., Mertens F., Johansson B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet. 15:1997;417-474
20. Yunis J.J. The chromosomal basis of human neoplasia. Science. 221:1984;227-236
21. Jacobs P.A. Mutation rates and structural chromosome rearrangements in man. Am J Hum Genet. 33:1981;44-54
22. Ma S.K., Chow E.Y.D., Wan T.S.K., Chan L.C. Robertsonian translocation as an acquired karyotypic abnormality in leukaemia. Br J Haematol. 98:1997;213-215
23. Multani A.S., Kacker R.K., Pathak S. Are robertsonian translocations rare in cancer? Cancer Genet Cytogenet. 93:1997;178-180
24. Seabright M. A rapid banding technique for human chromosomes. Lancet. 2:1971;971
25. Mitelman F. Guideline for cancer cytogenetics: supplement to an international system for human cytogenetic nomenclature. 1995;S Karger, Basel, Switzerland
26. ISCN. An international system for human cytogenetic nomenclature - high resolution banding: birth defects. Original article series. 17:1981;March of Dimes Birth Defects Foundation, New York
27. ISCN. An international system for human cytogenetic nomenclature: birth defects. Original article series. Vol 21. No 1:1985;The National Foundation, New York
28. Mitelman F, Johansson B and Mertens F, editors. Mitelman database of chromosome aberrations in cancer. Available at: http://cgap.nci.nih.gov/ Chromosomes/Mitelman. Accessed August 19, 2003.
29. Heerema N.A., Palmer C.G., Weetman R., Bertolone S. Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia. Leukemia. 6:1992;185-192
30. Zhao L., van Oort J., Cork A., Liang J.C. Comparison between interphase and metaphase cytogenetics in detecting chromosome 7 defects in hematological neoplasias. Am J Hematol. 43:1993;205-211
31. Downie P.A., Vogelzang N.J., Moldwin R.L., Le Beau M.M., Anastasi J., Allen R.J., Myers S.E., Larson R.A., Smith S.D. Establishment of a leukemia cell line with i(12p) from a patient with a mediastinal germ cell tumor and acute lymphoblastic leukemia. Cancer Res. 54:1994;4999-5004
32. Anastasi J., Pettenati M.J., Le Beau M.M., Kwaan H.C., Weil S.C. Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: cytogenetic analysis reveals two distinct abnormal clones. Am J Hematol. 29:1988;33-37
33. Ferro M.T., del Potro E., Krsnik I., Villegas A., Fernandez-Ranada J.M., Resino M., Garcia-Sagredo J.M., San-Roman C. Unusual translocations and other changes in acute leukemia. Cancer Genet Cytogenet. 54:1991;163-171
34. Kerndrup G.B., Kjeldsen E. Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping. Cancer Genet Cytogenet. 124:2001;7-11
35. Spurbeck J.L., Carlson R.O., Allen J.E., Dewald G.W. Culturing and robotic harvesting of bone marrow, lymph nodes, peripheral blood, fibroblasts, and solid tumors with in situ techniques. Cancer Genet Cytogenet. 32:1988;59-66
36. Roumier C., Eclache V., Imbert M., Davi F., MacIntyre E., Garand R., Talmant P., Lepelley P., Lai J.L., Casasnovas O., Maynadie M., Mugneret F., Bilhou-Naberra C., Valensi F., Radford I., Mozziconacci M.J., Arnoulet C., Duchayne E., Dastugue N., Cornillet P., Daliphard S., Garnache F., Boudjerra N., Jouault H., Fenneteau O., Pedron B., Berger R., Flandrin G., Fenaux P., Preudhomme C. Groupe Francais de Cytogenetique Hematologique (GFCH).; Groupe Francais d'Hematologie Cellulaire (GFHC). M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Francais d'Hematologie Cellulaire (GFHC) and the Groupe Francais de Cytogenetique Hematologique (GFCH). Blood. 101:2003;1277-1283
37. Massaad L., Prieur M., Gaud C., Fischer A., Dutrillaux B. Unusual karyotypic evolution in subacute myelomonocytic leukemia in two monozygotic twins. Cancer Genet Cytogenet. 38:1989;205-213
38. Lessard M., Herry A., Berthou C., Leglise M.C., Abgrall J.F., Morice P., Flandrin G. FISH investigation of 5q and 7q deletions in MDS/AML reveals hidden translocations, insertions and fragmentations of the same chromosomes. Leuk Res. 22:1998;303-312
39. Pedersen-Bjergaard J., Janssen W.G., Lyons J., Philip P., Bartram C.R. Point mutation of the ras protooncogenes and chromosome aberrations in acute nonlymphocytic leukemia and preleukemia related to therapy with alkylating agents. Cancer Res. 48:1988;1812-1817
40. Soni M., Brody J., Allen S.L., Schulman P., Kolitz J., Rai K., Broome J.D., Koduru P.R. Clinical and morphological features of cases of trisomy 13 in acute non-lymphocytic leukemia. Leukemia. 10:1996;619-623
41. Hawkins J.M., Moorman A.V., Hoffbrand A.V., Martineau M., Wright F.S., Mehta A.B., Prentice H.G., Secker-Walker L.M. Association of 17p loss with late-stage or refractory disease in hematologic malignancy. Cancer Genet Cytogenet. 77:1994;134-143
42. Hjorth M., Mark J., Tibblin E. A hypotriploid stemline with 4 Ph1 chromosomes in erythroleukemic blast crisis of a CML-patient with a long survival time. Hereditas. 93:1980;333-336
43. Peterson L.C., Lindquist L.L., Church S., Kay N.E. Frequent clonal abnormalities of chromosome band 13q14 in B-cell chronic lymphocytic leukemia: multiple clones, subclones, and nonclonal alterations in 82 midwestern patients. Genes Chromosomes Cancer. 4:1992;273-280
44. Huret J.L., Mossafa H., Brizard A., Dreyfus B., Guilhot F., Xue X.Q., Babin P., Tanzer J. Karyotypes of 33 patients with clonal aberrations in chronic lymphocytic leukaemia. Ann Genet. 32:1989;155-159
45. Oduru P.R., Susin M., Schulman P., Catell D., Goh J.C., Karp L., Broome J.D. Phenotypic and genotypic characterization of Hodgkin's disease. Am J Hematol. 44:1993;117-124
46. Sanchez-Izquierdo D., Siebert R., Harder L., Marugan I., Gozzetti A., Price H.P., Gesk S., Hernandez-Rivas J.M., Benet I., Sole F., Sonoki T., Le Beau M.M., Schlegelberger B., Dyer M.J., Garcia-Conde J., Martinez-Climent J.A. Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization. Leukemia. 15:2001;1475-1484
47. Horsman D.E., Connors J.M., Pantzar T., Gascoyne R.D. Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18). Genes Chromosomes Cancer. 30:2001;375-382
48. Berger R., Baranger L., Bernheim A., Valensi F., Flandrin G., Berheimm A. Cytogenetics of T-cell malignant lymphoma. Report of 17 cases and review of the chromosomal breakpoints. Cancer Genet Cytogenet. 36:1988;123-130
49. Schlegellberger B., Himmler A., Bartles H., Kuse R., Sterry W., Grote W. Recurrent chromosome abnormalities in peripheral T-cell lymphomas. Cancer Genet Cytogenet. 78:1994;15-22
50. Morgan R., Chen Z., Richkind K., Roherty S., Velasco J., Sandberg A.A. PHA/IL2: an efficient mitogen cocktail for cytogenetic studies of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Cancer Genet Cytogenet. 109:1999;134-137
51. Konishi H., Sakurai M., Nakao H., Maseki N., Kaneko Y., Yagiri Y., Notohara K., Frizzera G. Chromosome abnormalities in malignant lymphoma in patients from Kurashiki: histological and immunophenotypic correlations. Cancer Res. 50:1990;2698-2703
52. Pui C.H., Williams D.L., Raimondi S.C., Rivera G.K., Look A.T., Dodge R.K., George S.L., Behm F.G., Crist W.M., Murphy S.B. Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia. Blood. 70:1987;247-253
53. Carroll A.J., Raimondi S.C., Williams D.L., Behm F.G., Borowitz M., Castleberry R.P., Harris M.B., Patterson R.B., Pullen D.J., Crist W.M. tdic(9;12): a nonrandom chromosome abnormality in childhood B-cell precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood. 70:1987;1962-1965
54. Secker-Walker L.M., Stewart E.L., Chan L., O'Callaghan U., Chessells J.M. The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations. Br J Haematol. 61:1985;101-111
55. Mitelman F., Nilsson P.G., Brandt L., Alimena G., Gastaldi R., Dallapiccola B. Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia. Cancer Genet Cytogenet. 4:1981;197-214
56. Harbott J., Mancini M., Verellen-Dumoulin C., Moorman A.V., Secker-Walker L.M. Hematological malignancies with a deletion of 11q23: cytogenetic and clinical aspects. European 11q23 Workshop participants. Leukemia. 12:1998;823-827
57. Sole F., Prieto F., Badia L., Woessner S., Florensa L., Caballin M.R., Coll M.D., Besses C., Sans-Sabrafen J. Cytogenetic studies in 112 cases of untreated myelodysplastic syndromes. Cancer Genet Cytogenet. 64:1992;12-20
58. Lindvall C., Nordenskjold M., Porwit A., Bjorkholm M., Blennow E. Molecular cytogenetic characterization of acute myeloid leukemia and myelodysplastic syndromes with multiple chromosome rearrangements. Haematologica. 86:2001;1158-1164
59. Calasanz M.J., Cigudosa J.C., Odero M.D., Ferreira C., Ardanaz M.T., Fraile A., Carrasco J.L., Sole F., Cuesta B., Gullon A. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations. Genes Chromosomes Cancer. 18:1997;84-93
60. Sawyer J.R., Waldron J.A., Jagannath S., Barlogie B. Cytogenetic findings in 200 patients with multiple myeloma. Cancer Genet Cytogenet. 82:1995;41-49
61. Sole F., Woessner S., Acin P., Perez-Losada A., Florensa L., Besses C., Sans-Sabrafen J. Cytogenetic abnormalities in 13 patients with multiple myeloma. Cancer Genet Cytogenet. 86:1996;162-164
62. Chenevix-Trench G., Brown J.A., Tyler G.B., Behm F.G. Chromosome analysis of 30 cases of non-Hodgkin's lymphoma. Med Oncol Tumor Pharmacother. 5:1988;17-32
63. Jerkeman M., Johansson B., Akerman M., Cavallin-Stahl E., Kristoffersson U., Mitelman F. Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas. Eur J Haematol. 62:1999;184-190
64. Speaks S.L., Sanger W.G., Linder J., Johnson D.R., Armitage J.O., Weisenburger D., Purtilo D. Chromosomal abnormalities in indolent lymphoma. Cancer Genet Cytogenet. 27:1987;335-344
65. Pui C.H., Raimondi S.C., Williams D.L. Isochromosome 17q in childhood acute lymphoblastic leukemia: an adverse cytogenetic feature in association with hyperdiploidy? Leukemia. 2:1988;222-225
66. Levitt R., Pierre R.V., White W.L., Siekert R.G. Atypical lymphoid leukemia in ataxia telangiectasia. Blood. 52:1978;1003-1011
67. Ino T., Okamoto M., Tsuzuki M., Kamino I., Hirano M. An acquired Robertsonian 13;15 translocation in acute myelogenous leukemia (M5b). Int J Hematol. 59:1994;131-135
68. Le Beau M.M., Albain K.S., Larson R.A., Vardiman J.W., Davis E.M., Blough R.R., Golomb H.M., Rowley J.D. Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute onlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol. 4:1986;325-345
69. Mohr B., Bornhauser M., Thiede C., Schakel U., Schaich M., Illmer T., Pascheberg U., Ehninger G. Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome. Leukemia. 14:2000;1031-1038
70. Okada M., Mizoguchi H., Kubota K., Nomura Y. Quantitative analysis of chromosomal G-bands in human hematopoietic disorders by methotrexate synchronization technique. Cancer Genet Cytogenet. 13:1984;225-237
71. Musilova J., Michalova K. Chromosome study of 85 patients with myelodysplastic syndrome. Cancer Genet Cytogenet. 33:1988;39-50
72. Michalova K., Musilova J., Zemanova Z. Consecutive chromosomal studies in patients with myelodysplastic syndrome (MDS). Ann Genet. 134:1991;212-218
73. Pedersen-Bjergaard J., Pedersen M., Roulston D., Philip P. Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia. Blood. 86:1995;3542-3552
74. Hirst W.J., Czepulkowski B., Mufti G.J. Consistent interstitial chromosomal deletions in myeloid malignancies and their correlation with fragile sites. Cancer Genet Cytogenet. 65:1993;51-57
75. Hammond D.W., Goepel J.R., Aitken M., Hancock B.W., Potter A.M., Goyns M.H. Cytogenetic analysis of a UK series of non-Hodgkins lymphomas. Cancer Genet Cytogenet. 61:1992;31-38
76. Hashimoto K., Miura I., Chyubachi A., Saito M., Miura A.B. Correlations of chromosome abnormalities with histologic and immunologic characteristics in 49 patients from Akita, Japan with non-Hodgkin lymphoma. Cancer Genet Cytogenet. 81:1995;56-65
77. Betts D.R., Riesch M., Grotzer M.A., Niggli F.K. The investigation of karyotypic instability in the high-hyperdiploidy subgroup of acute lymphoblastic leukemia. Leuk Lymphoma. 42:2001;187-193
78. Leroux D., Mugneret F., Callanan M., Radford-Weiss I., Dastugue N., Feuillard J., Le Mee F., Plessis G., Talmant P., Gachard N., Uettwiller F., Pages M.P., Mozziconacci M.J., Eclache V., Sibille C., Avet-Loiseau H., Lafage-Pochitaloff M. CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Francais de Cytogenetique Hematologique. Blood. 99:2002;4154-4159
79. Fischer K., Frohling S., Scherer S.W., McAllister Brown J., Scholl C., Stilgenbauer S., Tsui L.C., Lichter P., Dohner H. Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias. Blood. 89:1997;2036-2041
80. Yaspo M.L., Theophile D., Aurias A., Crete N., Creau-Goldberg N., Bastard C., Suberville A.M., Valensi F., Viguier F., Berger R.l. Molecular analysis of 12 patients with the t(8;21) translocation and M2 acute myelogenous leukemia. Genes Chromosomes Cancer. 5:1992;166-177
81. Van Limbergen H., Poppe B., Michaux L., Herens C., Brown J., Noens L., Berneman Z., De Bock R., De Paepe A., Speleman F. Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. Genes Chromosomes Cancer. 33:2002;60-72
82. Prigogina E.L., Fleischman E.W., Puchkova G.P., Mayakova S.A., Volkova M.A., Protasova A.K., Frenkel M.A. Chromosomes in acute nonlymphocytic leukemia. Hum Genet. 73:1986;137-146
83. Fairman J., Wang R.Y., Liang H., Zhao L., Saltman D., Liang J.C., Nagarajan L. Translocations and deletions of 5q13.1 in myelodysplasia and acute myelogenous leukemia: evidence for a novel critical locus. Blood. 88:1996;2259-2266
84. Finn W.G., Kay N.E., Kroft S.H., Church S., Peterson L.C. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. Am J Hematol. 59:1988;223-229
85. Nillson T., Lenhoff S., Turesson I., Rylander L., Mitelman F., Westin J., Hoglund M., Johansson B. Cytogenetic features of multiple myeloma: impact of gender, age, disease phase, culture time, and cytokine stimulation. Eur J Haematol. 68:2002;345-353
86. Biggar R.J., Lee E.C., Nkrumah F.K., Whang-Peng J. Direct cytogenetic studies by needle aspiration of Burkitt's lymphoma in Ghana, West Africa. J Natl Cancer Inst. 67:1981;769-776
87. Knuutila S., Elonen E., Heinonen K., Borgstrom G.H., Lakkala-Paranko T., Perkkio M., Franssila K., Teerenhovi L., Ekblom M., von Willebrand E. Chromosome abnormalities in 16 Finnish patients with Burkitt's lymphoma or L3 acute lymphocytic leukemia. Cancer Genet Cytogenet. 13:1984;139-151
88. Heerema N.A., Sather H.N., Sensel M.G., Lee M.K., Hutchinson R.J., Nachman J.B., Reaman G.H., Lange B.J., Steinherz P.G., Bostrom B.C., Gaynon P.S., Uckun F.M. Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia. J Clin Oncol. 18:2000;3837-3844
89. Rack K.A., Cornelis F., Radford-Weiss I., Bernheim A., Harrison C.J., Hermine O., Prieur M., Vekemans M., Macintyre E.A. A chromosome 14q11/TCRalfa/delta specific yeast artificial chromosome improves the detection rate and characterization of chromosome abnormalities in T-lymphoproliferative disorders. Blood. 90:1997;1233-1240
90. Tusell L., Caballin M.R., Coll M.D., Ortega J.J., Egozcue J. Isochromosome 14q in childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet. 80:1995;78-79
91. Silva M.L.M., Zalcberg I.Q., de Souza M.H.O., Simoes F.V., Carrico K.C., Tabak D.G., Ribeiro P.C., Abdelhay E. Isochromosome 14q in T cell childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet. 81:1996;92-93
92. Mancini M., Vegna M.L., Castoldi G.L., Mecucci C., Spirito F., Elia L., Tafuri A., Annino L., Pane F., Rege-Cambrin G., Gottardi M., Leoni P., Gallo E., Camera A., Luciano L., Specchia G., Torelli G., Sborgia M., Gabbas A., Tedeschi A., Della Starza I., Cascavilla N., Di Raimondo F., Mandelli F., Foa R. Partial deletions of long arm of chromosome 6: biologic and clinical implications in adult acute lymphoblastic leukemia. Leukemia. 16:2002;2055-2061
93. Secker-Walker L.M., Mehta A., Bain B. Abnormalities of 3q21 and 3q26 in myeloid malignancy: a UK Cancer Cytogenetic Group study. Br J Haematol. 91:1995;490-501
94. Meloni-Balliet A., Morgan R., Poth J.L., Kingsley E.C., Sandberg A.A. Trisomy 14: a new entity within acute nonlymphocytic leukemia. Cancer Genet Cytogenet. 43:1989;35-38
95. Shi G., Weh H.J., Duhrsen U., Zeller W., Hossfeld D.K. Chromosomal abnormality inv(3)(q21q26) associated with multilineage hematopoietic progenitor cells in hematopoietic malignancies. Cancer Genet Cytogenet. 96:1997;58-63
96. Poirel H., Jonveaux P., Daniel M.T., Berger R. Trisomy 14: a recurring cytogenetic abnormality associated with myeloid disorders. Leuk Lymphoma. 17:1995;455-457
97. Sole F., Caballin M.R., Coll M.D., Woessner S., Besses C., Sans-Sabrafen J., Egozcue J. Cytogenetic studies in acute nonlymphocytic leukemia. Cancer Genet Cytogenet. 60:1992;117-124
98. Olopade O.I., Thangavelu M., Larson R.A., Mick R., Kowal-Vern A., Schumacher H.R., Le Beau M.M., Vardiman J.W., Rowley J.D. Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia. Blood. 80:1992;2873-2882
99. Andreasson P., Johansson B., Billstrom R., Garwicz S., Mitelman F., Hoglund M. Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements. Leukemia. 12:1998;390-400
100. Luan X., Ramesh K.H., Cannizzaro L.A. FHIT gene transcript alterations occur frequently in myeloproliferative and myelodysplastic diseases. Cytogenet Cell Genet. 81:1998;183-188
101. Willman C.L., Sever C.E., Pallavicini M.G., Harada H., Tanaka N., Slovak M.L., Yamamoto H., Harada K., Meeker T.C., List A.F. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science. 259:1993;968-971
102. Reddy K.S. Trisomy 14 and leukemia. Cancer Genet Cytogenet. 106:1998;144-151
103. Sadamori N., Takei H., Yao E., Nagamine M., Tomonaga Y., Tagawa M., Kusano M., Ichimaru M. Erythrocyte glutathione reductase activity and acquired trisomy #8 in various hematologic disorders. Cancer Genet Cytogenet. 12:1984;255-259
104. Sole F., Caballin M.R., Coll M.D., Woessner S., Besses C., Palou L., Egozcue J. Isochromosome 14q in myeloid dysplastic disorder. Cancer Genet Cytogenet. 54:1991;133-134
105. Mancini M., Cedrone M., Nanni M., Rondinelli M.B., Petti M.C., De Cuia M.R., Alimena G. Trisomy 14 in hematologic diseases. Another non-random abnormality within myeloid proliferative disorders. Cancer Genet Cytogenet. 66:1993;39-42
106. Pinkerton P.H., London B., Dube I.D., Senn J.S. Trisomy 14 in myelodysplastic syndromes. Cancer Genet Cytogenet. 49:1990;113-116
107. Boavida M.G., Ambrosio P., Dhermy D., Silva C., Correia M.E. Jr. Isochromosome 14q in refractory anemia. Cancer Genet Cytogenet. 97:1997;155-156
108. Abe Y., Muta K., Yufu Y., Takahira H., Nishimura J., Nawata H. The transferrin receptor system is not involved in the pathogenesis of hematological disorders with 3q inversion. Am J Hematol. 33:1990;215-219
109. Maeck L., Haase D., Schoch C., Hiddemann W., Alves F. Genetic instability in myelodysplastic syndrome: detection of microsatellite instability and loss of heterozygosity in bone marrow samples with karyotype alterations. Br J Haematol. 109:2000;842-846
110. Rigolin G.M., Cuneo A., Roberti M.G., Bardi A., Castoldi G. Myelodysplastic syndromes with monocytic component: hematologic and cytogenetic characterization. Haematologica. 82:1997;25-30
111. Liu H.W., Lie K.W., Chan L.C. Isochromosome 14q and leukemia with dysplastic features. Cancer Genet Cytogenet. 64:1992;97-98
112. Flaherty L., Jarvis A., Harris M., Tyrrell V., Smith A. A case of chronic myelomonocytic leukemia with isochromosome 14q. Cancer Genet Cytogenet. 101:1998;134-137
113. Toze C.L., Barnett M.J., Naiman S.C., Horsman D.E. Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies. Br J Haematol. 98:1997;177-185
114. Ribera J.M., Aventin A., Milla F., Las Heras G. Isochromosome 14q in chronic myelomonocytic leukemia. Cancer Genet Cytogenet. 52:1991;139-140
115. Saghir F., Abboud E., Veres C., Feldman L. A myeloproliferative disorder associated with isochromosome 14q. Am J Med Sci. 324:2002;166-169
116. Johansson B., Billstrom R., Broberg K., Fioretos T., Nilsson P.G., Ahlgren T., Malm C., Samuelsson B.O., Mitelman F. Cytogenetic polyclonality in hematologic malignancies. Genes Chromosomes Cancer. 24:1999;222-229
117. Mossafa H., Brizard A., Huret J.L., Brizard F., Lessard M., Guilhot F., Tanzer J. Trisomy 8q due to i(8q) or der(8)t(8;8) is a frequent lesion in T-prolymphocytic leukaemia: four new cases and a review of the literature. Br J Haematol. 86:1994;780-785
118. Chen K.C., Bevan P.C., Matthews J.G. Analysis of G banded karyotypes in myeloma cells. J Clin Pathol. 39:1986;260-266
119. Dohner H., Bloomfield C.D., Frizzera G., Frestedt J., Arthur D.C. Recurring chromosome abnormalities in Hodgkin's disease. Genes Chromosomes Cancer. 5:1992;392-398
120. Pederson R.K., Sorensen A.G., Pedersen N.T., Schmidt K.G., Kerndrup G.B. Chromosome aberrations in adult Hodgkin disease in a Danish population-based study. Cancer Genet Cytogenet. 110:1999;128-132
121. Schlegelberger B., Weber-Matthiesen K., Himmler A., Bartels H., Sonnen R., Kuse R., Feller A.C., Grote W. Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin's disease. Leukemia. 8:1994;72-80
122. Cuthbert G., Thompson K., McCullough S., Watmore A., Dickinson H., Telford N., Mugneret F., Harrison C., Griffiths M., Bown N. MLL amplification in acute leukaemia: a UK Cancer Cytogenetics Group (UKCCG) study. Leukemia. 14:2000;1885-1891
123. Chinnappan D., Philip A., Wu X., Pan A., Wyandt H.E. Acquired Robertsonian translocations in two leukemia patients. Cancer Genet Cytogenet. 131:2001;104-108
124. Smadja N.V., Bastard C., Brigaudeau C., Leroux D., Fruchart C. Groupe Francais de Cytogenetique Hematologique. Hypodiploidy is a major prognostic factor in multiple myeloma. Blood. 98:2001;2229-2238
125. Loncarevic I.F., Roitzheim B., Ritterbach J., Viehmann S., Borkhardt A., Lampert F., Harbott J. Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion. Genes Chromosomes Cancer. 24:1999;272-277
126. Tricot G., Broeckaert-van Orshoven A., Casteels-van Daele M., van den Berghe H. 8/21 translocation in acute myeloid leukaemia. Scand J Haematol. 26:1981;168-176
127. Horsman D.E., Kalousek D.K. Acquired Robertsonian translocations in hematologic malignancy. A rare mechanism of clonal evolution. Cancer Genet Cytogenet. 45:1990;193-196
128. Sawyer J.R., Lukacs J.L., Munshi N., Desikan K.R., Singhal S., Mehta J., Siegel D., Shaughnessy J., Barlogie B. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping. Blood. 92:1998;4269-4278
129. Crossen P.E., Tully S.M., Benjes S.M., Hollings P.E., Beard M.E., Nimmo J.C., Morrison M.J. Oligoclonal B-cell leukemia characterized by spontaneous cell division and telomere association. Genes Chromosomes Cancer. 8:1993;49-59
130. Taniwaki M., Nishida K., Takashima T., Nakagawa H., Fujii H., Tamaki T., Shimazaki C., Horiike S., Misawa S., Abe T. Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. Blood. 84:1994;2283-2290
131. Nashelsky M.B., Hess M.M., Weisenburger D.D., Pierson J.L., Bast M.A., Armitage J.O., Sanger W.G. Cytogenetic abnormalities in B-immunoblastic lymphoma. Leuk Lymph. 14:1994;415-420
132. Colleoni G.W., Bridge J.A., Garicochea B., Liu J., Filippa D.A., Ladanyi M. ATIC-ALK: a novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35). Am J Path. 156:2000;781-789
133. Mark J., Dahlenfors R., Ekedahl C. Recurrent chromosomal aberrations in non-Hodgkin and non-Burkitt lymphomas. Cancer Genet Cytogenet. 1:1979;39-56
134. Michalova K., Kobylka P., Lukasova M. Neuwirt. Cytogenetic study of circulating blasts in leukemias. Cancer Genet Cytogenet. 25:1987;329-339
135. Raimondi S.C., Behm F.G., Roberson P.K., Williams D.L., Pui C.H., Crist W.M., Look A.T., Rivera G.K. Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19). J Clin Oncol. 8:1990;1380-1388
136. Chen Z., Morgan R., Baer M.R., Ligorsky R., Sandberg A.A. Translocation (3;21) characterizes crises in myeloid stem cell disorders. Cancer Genet Cytogenet. 57:1991;153-159
137. Ladanyi M., Parsa N.Z., Offit K., Wachtel M.S., Filippa D.A., Jhanwar S.C. Clonal cytogenetic abnormalities in Hodgkin's disease. Genes Chromosomes Cancer. 3:1991;294-299
138. Lu X.Y., Harris C.P., Cooley L., Margolin J., Steuber P.C., Sheldon M., Rao P.H., Lau C.C. The utility of spectral karyotyping in the cytogenetic analysis of newly diagnosed pediatric acute lymphoblastic leukemia. Leukemia. 16:2002;2222-2227
139. Hayashi Y., Raimondi S.C., Look A.T., Behm F.G., Kitchingman G.R., Pui C.H., Rivera G.K., Williams D.L. Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia. Blood. 76:1990;1626-1630
140. Thomas X., Thiebaut A., Olteanu N., Danaila C., Charrin C., Archimbaud E., Fiere D. Philadelphia chromosome positive adult acute lymphoblastic leukemia: characteristics, prognostic factors and treatment outcome. Hematol Cell Ther. 40:1998;119-128
141. Raimondi S.C., Roberson P.K., Pui C.H., Behm F.G., Rivera G.K. Hyperdiploid (47-50) acute lymphoblastic leukemia in children. Blood. 79:1992;3245-3252
142. Martineau M., Clark R., Farrell D.M., Hawkins J.M., Moorman A.V., Secker-Walker L.M. Isochromosomes in acute lymphoblastic leukaemia: i(21q) is a significant finding. Genes Chromosomes Cancer. 17:1996;21-30
143. Pui C.H., Carroll A.J., Raimondi S.C., Schell M.J., Head D.R., Shuster J.J., Crist W.M., Borowitz M.J., Link M.P., Behm F.G. Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases. Blood. 79:1992;2384-2391
144. Coignet L.J., Lima C.S., Min T., Streubel B., Swansbury J., Telford N., Swanton S., Bowen A., Nagai M., Catovsky D., Fonatsch C., Dyer M.J. Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia. Genes Chromosomes Cancer. 25:1999;222-229
145. Schmitz N., Johannson W., Schmidt G., von der Helm K., Loffler H. Recurrence of acute lymphoblastic leukemia in donor cells after allogeneic marrow transplantation associated with a deletion of the long arm of chromosome 6. Blood. 70:1987;1099-1104
146. Cuneo A., Ferrant A., Michaux J.L., Bosly A., Chatelain B., Stul M., Dal Cin P., Dierlamm J., Cassiman J.J., Hossfeld D.K., Castoldi G., Van den Berghe H. Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases. Cancer Genet Cytogenet. 92:1996;31-36
147. Bow E.J., Gallant G., Williams G.J., Woloschuk D., Shore T.B., Rubinger M., Schacter B.A. Remission induction therapy of untreated acute myeloid leukemia using a non-cytarabine-containing regimen of idarubicin, etoposide, and carboplatin. Cancer. 83:1998;1344-1354
148. Davey F.R., Abraham N. Jr., Brunetto V.L., MacCallum J.M., Nelson D.A., Ball E.D., Griffin J.D., Baer M.R., Wurster-Hill D., Mayer R.J. Morphologic characteristics of erythroleukemia (acute myeloid leukemia; FAB-M6): a CALGB study. Am J Hematol. 49:1995;29-38
149. Nakamura H., Sasagawa I., Itoyama T., Mine M., Amenomori T., Sadamori N., Tomonaga M. Cytogenetic studies of non-lymphocytic neoplasias using hematopoietic growth factors: gM-CSF provides pronounced mitotic increase and improvement of the quality of banded chromosomes compared to G-CSF. Leukemia. 7:1993;1471-1475
150. Koller U., Haas O.A., Ludwig W.D., Bartram C.R., Harbott J., Panzer-Grumayer R., Hansen-Hagge T., Ritter J., Creutzig U., Knapp W. Phenotypic and genotypic heterogeneity in infant acute leukemia II. Acute nonlymphoblastic leukemia. Leukemia. 3:1989;708-714
151. Park K.U., Lee D.S., Lee H.S., Kim C.J., Cho H.I. Granulocytic sarcoma in MLL-positive infant acute myelogenous leukemia. Fluorescence in situ hybridization study of childhood acute myelogenous leukemia for detecting MLL rearrangement. Am J Pathol. 159:2001;2011-2016
152. Katz F., Webb D., Gibbons B., Reeves B., McMahon C., Chessells J., Mitchell C. Possible evidence for genomic imprinting in childhood acute myeloblastic leukaemia associated with monosomy for chromosome 7. Br J Haematol. 80:1992;332-336
153. Leverger G., Bernheim A., Daniel M.T., Flandrin G., Schaison G., Berger R. Cytogenetic study of 130 childhood acute nonlymphocytic leukemias. Med Pediatr Oncol. 16:1988;227-232
154. Odero M.D., Carlson K.M., Calasanz M.J., Rowley J.D. Further characterization of complex chromosomal rearrangements in myeloid malignancies: spectral karyotyping adds precision in defining abnormalities associated with poor prognosis. Leukemia. 15:2001;1133-1136
155. Keinanen M., Griffin J.D., Bloomfield C.D., Machnicki J., de la Chapelle A. Clonal chromosomal abnormalities showing multiple-cell-lineage involvement in acute myeloid leukemia. N Engl J Med. 318:1988;1153-1158
156. Kocova M.J., Sandberg A.A. Major karyotypic abnormalities in a near-tetraploid erythroleukemia. Cancer Genet Cytogenet. 17:1985;143-150
157. Cuneo A., Fagioli F., Pazzi I., Tallarico A., Previati R., Piva N., Carli M.G., Balboni M., Castoldi G. Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents. Leuk Res. 16:1992;789-796
158. Viguie F., Aboura A., Bouscary D., Guesnu M., Baumelou E., Dreyfus F., Casadevall N., Tachdjian G. Isodicentric/pseudoisodicentric chromosome 21 amplification in four cases of acute myelocytic leukemia or myelodysplasia. Cancer Genet Cytogenet. 138:2002;80-84
159. Lima M., Porto B., Rodrigues M., Teixeira M.A., Coutinho J., Ribeiro A.C., Malheiro M.I., Justica B. Cytogenetic findings in a patient presenting simultaneously with chronic lymphocytic leukemia and acute myeloid leukemia. Cancer Genet Cytogenet. 87:1996;38-40
160. Lynch H.T., Weisenburger D.D., Quinn-Laquer B., Snyder C.L., Lynch J.F., Lipkin S.M., Sanger W.G. Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer. Cancer Genet Cytogenet. 137:2002;8-14
161. Werner-Favre C., Cabrol C., Beris P., Engel E. Isochromosome 21 and other chromosomal abnormalities in a patient with erythroleukaemia. Ann Genet. 26:1983;240-242
162. Huret J.L., Schoenwald M., Gabarre J., Vaugier G.L., Tanzer J. Two additional cases of isochromosome 21q or translocation 21q21q in hematological malignancies. Acta Hematol. 86:1991;111-114
163. Haase D., Feuring-Buske M., Schafer C., Schoch C., Troff C., Gahn B., Hiddemann W., Wormann B. Cytogenetic analysis of CD34+ subpopulations in AML and MDS characterized by the expression of CD38 and CD117. Leukemia. 11:1997;674-679
164. Salido M., Sole F., Espinet B., Fernandez C., Zamora L., Woessner S., Florensa L. Pentasomy 21 with two isochromosomes 21 in a case of acute myeloid leukemia without maturation. Cancer Genet Cytogenet. 132:2003;71-73
165. Berger R., Bernheim A., Le Coniat M., Vecchione D., Pacot A., Daniel M.T., Flandrin G. Abnormalities of the short arm of chromosome 12 in acute nonlymphocytic leukemia and dysmyelopoietic syndrome. Cancer Genet Cytogenet. 19:1986;281-289
166. Groupe Francais de Cytogenetique Hematologique. Cytogenetic analysis in patients with primary myelodysplastic syndromes in leukaemic transformation. Hematol Cell Ther. 38:1996;177-181
167. Pedersen-Bjergaard J., Philip P. Cytogenetic characteristics of therapy-related acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive cases. Br J Haematol. 66:1987;199-207
168. Abrahamson G.M., Rack K., Buckle V.J., Oscier D.G., Kelly S., Wainscoat J.S. Translocation 1;7 in hematologic disorders - A report of three further cases. Absence of amplification of the gene for the epidermal growth factor receptor. Cancer Genet Cytogenet. 53:1991;91-95
169. Manley R., Cochrane J., Patton W.N. Polyploidy in myelodysplastic syndrome: a case report. Cancer Genet Cytogenet. 106:1998;170-172
170. Sessarego M., Fugazza G., Gobbi M., Bruzzone R., Bisio R., Ghio R., Patrone F. Complex structural involvement of chromsome 7 in primary myelodysplastic syndromes determined by fluorescence in situ hybridization. Cancer Genet Cytogenet. 106:1998;110-115
171. Stephenson J., Czepulkowski B., Hirst W., Mufti G.J. Deletion of the acetylcholinesterase locus at 7q22 associated with myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). Leuk Res. 20:1996;235-241
172. Abrahamson G.M., Rack K., Oscier D.G., Fitchett M., Buckle V.J., Wainscoat J.S. Comparison of cytogenetic and restriction fragment length polymorphism analyses for the detection of loss of chromosome material in clonal hemopoietic disorders. Am J Hematol. 42:1993;171-176
173. Andrieux J., Demory J.L., Caulier M.T., Agape P., Wetterwald M., Bauters F., Lai J.L. Karyotypic abnormalities in myelofibrosis following polycythemia vera. Cancer Genet Cytogenet. 140:2003;118-123
174. Lai J.L., Michaux L., Dastugue N., Vasseur F., Daudignon A., Facon T., Bauters F., Zandecki M. Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant. Cancer Genet Cytogenet. 104:1998;133-138
175. Poppema S., Kaleta J., Hepperle B. Chromosomal abnormalities in patients with Hodgkin's disease: evidence for frequent involvement of the 14q chromosomal region but infrequent bcl-2 gene rearrangement in Reed-Sternberg cells. J Natl Cancer Inst. 84:1992;1789-1793
176. Tilly H., Bastard C., Delastre T., Duval C., Bizet M., Lenormand B., Dauce J.P., Monconduit M., Piguet H. Cytogenetic studies in untreated Hodgkin's disease. Blood. 77:1991;1298-1304
177. Peters K., Zettl A., Starostik P., Greiner A., Rosenwald A., Katzenberger T., Ott G., Muller-Hermelink H.K. Genetic imbalances in primary gastric diffuse large B-cell lymphomas: comparison of comparative genomic hybridization, microsatellite, and cytogenetic analysis. Diagn Mol Pathol. 9:2000;58-65
178. Dreyling M.H., Roulston D., Bohlander S.K., Vardiman J., Olopade O.I. Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma. Genes Chromosomes Cancer. 22:1998;72-78
179. Sueoka N., Inokuchi K., Nishigaki H., Futaki M., Inokuchi M., Sugisaki Y., Dan K., Wakabayashi I. Genotype configuration in a case of primary gastric lymphoma with T-cell phenotype. Cancer Genet Cytogenet. 101:1998;103-108
180. Labal de Vinuesa M., Slavutsky I., Larripa I. Presence of isochromosomes in hematologic diseases. Cancer Genet Cytogenet. 25:1987;47-54
181. Ohno H., Kerckaert J.P., Bastard C., Fukuhara S. Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27. Jpn J Cancer Res. 85:1984;592-600
182. Siebert R., Matthiesen P., Harder S., Zhang Y., Borowski A., Zuhlke-Jenisch R., Plendl H., Metzke S., Joos S., Zucca E., Weber-Matthiesen K., Roggero E., Grote W., Schlegelberger B. Application of interphase cytogenetics for the detection of t(11;14)(q13;q32) in mantle cell lymphomas. Ann Oncol. 9:1998;519-526
183. Mandal A.K., Roberts S.H., Laurence K.M. Double i(18q) in lymphoma. Cancer Genet Cytogenet. 44:1990;279-281
184. Fleischman E.W., Prigogina E.L., Ilynskaya G.W., Probatova N.A., Konstantinova L.N., Kruglova G.V., Volkova M.A., Osmanov D.S. Chromosomal characteristics of malignant lymphoma. Hum Genet. 82:1989;343-348
185. Au W.Y., Gascoyne R.D., Viswanatha D.S., Connors J.M., Klasa R.J., Horsman D.E. Cytogenetic analysis in mantle cell lymphoma: a review of 214 cases. Leuk Lymphoma. 43:2002;783-791
186. LePretre S., Buchonnet G., Stamatoullas A., Lenain P., Duval C., d'Anjou J., Callat M.P., Tilly H., Bastard C. Chromosome abnormalities in peripheral T-cell lymphoma. Cancer Genet Cytogenet. 117:2000;71-79
187. Ramakers-van Woerden N.L., Pieters R., Loonen A.H., Hubeek I., van Drunen E., Beverloo H.B., Slater R.M., Harbott J., Seyfarth J., van Wering E.R., Hahlen K., Schmiegelow K., Janka-Schaub G.E., Veerman A.J. TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia. Blood. 96:2000;1094-1099
188. Kowalczyk J.R., Grossi M., Sandberg A.A. Cytogenetic findings in childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet. 15:1985;47-64
189. McConnell T.S., Foucar K., Hardy W.R., Saiki J. Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome. J Clin Oncol. 5:1987;2042-2044
190. Geisler C.H., Philip P., Christensen B.E., Hou-Jensen K., Pedersen N.T., Jensen O.M., Thorling K., Andersen E., Birgens H.S., Drivsholm A., Ellegaard J., Larsen J.K., Plesner T., Brown P., Andersen P.K., Hansen M.M. In B-cell chronic lymphocytic leukemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients. Leuk Res. 21:1997;1011-1023
191. Gad S.G., Callen D.F., Kuss B., Downing J.R., Behm F., Head D., Ribeiro R.C., Raimondi S.C. Identification of an inversion 16 coexisting with an isochromosome 22q by in situ hybridization in a case of childhood AML M4e. Leukemia. 7:1993;1658-1662
192. Berger R., Flandrin G., Bernheim A., Le Coniat M., Vecchione D., Pacot A., Derre J., Daniel M.T., Valensi F., Sigaux F. Cytogenetic studies on 519 consecutive de novo acute nonlymphocytic leukemias. Cancer Genet Cytogenet. 29:1987;9-21
193. Bitter M.A., Neilly M.E., Le Beau M.M., Pearson M.G., Rowley J.D. Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia. Blood. 66:1985;1362-1370
194. Morrison V.A., Rai K.R., Peterson B.L., Kolitz J.E., Elias L., Appelbaum F.R., Hines J.D., Shepherd L., Larson R.A., Schiffer C.A. Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. J Clin Oncol. 20:2002;3878-3884
195. Johansson B., Billstrom R., Kristoffersson U., Akerman M., Garwicz S., Ahlgren T., Malm C., Mitelman F. Deletion of chromosome arm 3p in hematologic malignancies. Leukemia. 11:1997;1207-1213
196. Pedersen B., Jensen I.M. Clinical and prognostic implications of chromosome 5q deletions: 96 high resolution studied patients. Leukemia. 5:1991;566-573
197. Mrozek K., Heinonen K., Theil K.S., Bloomfield C.D. Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q. Genes Chromosomes Cancer. 34:2003;137-153
198. Geddes A.A., Bowen D.T., Jacobs A. Clonal karyotype abnormalities and clinical progress in the myelodysplastic syndrome. Br J Haematol. 76:1990;194-202
199. Michels S.D., Saumur J., Arthur D.C., Robison L.L., Brunning R.D. Refractory anemia with excess of blasts in transformation. Hematologic and clinical study of 52 patients. Cancer. 64:1989;2340-2346
200. Werner M., Kaloutsi V., Buhr T., Delventhal S., Vykoupil K.F., Georgii A. Cytogenetics of chronic myelogenous leukemia (CML) correlated to the histopathology of bone marrow biopsies. Ann Hematol. 63:1991;201-205
201. Le Baccon P., Leroux D., Dascalescu C., Duley S., Marais D., Esmenjaud E., Sotto J.J., Callanan M. Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma. Genes Chromosomes Cancer. 32:2001;250-264
202. Alqahtani M.H., Hammond D.W., Goepel J.R., Goyns M.H. Cytogenetic analysis of non Hodgkin's lymphomas by ratio-painting and comparative genomic hybridization reveals unsuspected chromosomal abnormalities. Leuk Lymphoma. 35:1999;325-337
203. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A.G., Gralnick H.R., Sultan C. Proposed revised criteria for the classification of acute myeloid leukaemia: a report of the French-American-British Cooperative Group. Ann Intern Med. 103:1985;626-629
204. Welborn J. Constitutional chromosome aberrations as pathogenetic events in hematologic malignancies. Cancer Genet Cytogenet. 149:2003;137-153
205. Mitelman F., Heim S. Quantitative acute leukemia cytogenetics. Genes Chrom Cancer. 5:1992;57-66
206. Heim S., Mitelman F. Cancer cytogenetics: chromosomal and molecular genetic aberrations of tumor cells. 2nd edition:1995;Wiley-Liss, Inc, New York
207. Sinclair E.J., Potter A.M., Watmore A.E., Fitchett M., Ross F. Trisomy 15 associated with loss of the Y chromosome in bone marrow: a possible new aging effect. Cancer Genet Cytogenet. 105:1998;20-23
208. Reddy K.S., Sbeiti A. Trisomy 15 in hematological disorders. Cancer Genet Cytogenet. 116:2000;176-177
209. Berger R. Acute lymphoblastic leukemia and chromosome 21. Cancer Genet Cytogenet. 94:1997;8-14
210. Mitleman F. Trisomy 21 in neoplastic cells. Amer J Med Genet Supple. 7:1990;262-266
211. Hasle H., Clemmensen I.H., Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet. 355:2000;165-169
212. San Miguel J.F., Gonzalez M., Canizo M.C., Ojeda E., Orfao A., Caballero M.D., Moro M.J., Fisac P., Lopez Borrasca A. Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics. Blood. 72:1988;402-407
213. Huang M.J., Li C.Y., Nichols W.L., Young J.H., Katzmann J.A. Acute leukemia with megakaryocytic differentiation: a study of 12 cases identified immunocytochemically. Blood. 64:1984;427-439
214. Tallman M.S., Neuberg D., Bennett J.M., Francois C.J., Paietta E., Wiernik P.H., Dewald G., Cassileth P.A., Oken M.M., Rowe J.M. Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. Blood. 96:2000;2405-2411
215. Niemeyer M.M., Haak H.L., Augustinus E., den Nijs-van Weert J.I., Leeksma C.H. Trisomy of chromosome 22 in acute myelomonocyic leukaemia. Cancer Genet Cytogenet. 20:1986;371-374
216. Pinheiro R.F., Lopes Ferrari Chauffaille Mde L., Vicari P., Rodrigues C.A., Pelloso L.A., Bordin J.O., Yamamoto M. Trisomy 22: a subclone marker? Cancer Genet Cytogenet. 143:2003;85-86
217. Grois N., Nowotny H., Tyl E., Krieger O., Kier P., Haas O.A. Is trisomy 22 in acute myeloid leukaemia a primary abnormality or only a secondary change associated with inversion 16? Cancer Genet Cytogenet. 43:1989;119-129
218. Langabeer S.E., Walker H., Gale R.E., Wheatley K., Burnett A.K., Goldstone A.H., Linch D.C. Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the UK MRC AML trials. Br J Haematol. 96:1997;736-739
219. Ritter M., Thiede C., Schäkel U., Schmidt M., Alpen B., Pascheberg U., Mohr B., Ehninger G., Neubauer A. Underestimation of inversion (16) in acute myeloid leukaemia using standard cytogenetics as compared with polymerase chain reaction: results of a prospective investigation. Br J Haematol. 98:1997;969-972
220. Wong K.F., Wong Y.L. Trisomy 22 in acute myeloid leukemia a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16. Cancer Genet Cytogenet. 106:1999;131-133
221. Wong K.L., Wong Y.L. Isochromosome 8q is a marker of secondary acute myeloid leukemia. Cancer Genet Cytogenet. 120:2000;171-173
222. Kwong Y.L., Chan T.K. Pentasomy 8q in myelodysplasia. Cancer Genet Cytogenet. 100:1998;179-181
223. Alitalo T., Willard H.F., de la Chapelle A. Determination of the breakpoints of 1;7 translocations in myelodysplastic syndrome by in situ hybridization using chromosome-specific alpha satellite DNA from human chromosomes 1 and 7. Cytogenet Cell Genet. 50:1989;49-53
224. Bajalica S., Brondum-Nielsen K., Sorensen A.G., Pedersen N.T., Heim S. Identification of a whole-arm translocation by in situ hybridization with directly fluorochrome-labeled probes in a myelodysplastic syndrome. Genes Chromosomes Cancer. 5:1992;128-131
225. Tuck-Muller C.M., Narayan A., Tsien F., Smeets D.F., Sawyer J., Fiala E.S., Sohn O.S., Ehrlich M. DNA hypomethylation and unusual chromosome instability in cell lines from ICF syndrome patients. Cytogenet Cell Genet. 89:2000;121-128
226. Melki J.R., Clark S.J. DNA methylation changes in leukaemia. Semin Cancer Biol. 12:2002;347-357
227. Knudson A.G. Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol. 122:1996;135-140
228. Carlebach M., Amiel A., Gaber E., Radnay J., Manor Y., Fejgin M., Lishner M. Multiple myeloma: monoallelic deletions of the tumor suppressor genes TP53 and RB1 in long-term follow-up. Cancer Genet Cytogenet. 117:2000;57-60
229. Zhu Y.M., Haynes A.P., Keith F.J., Russell N.H. Abnormalities of retinoblastoma gene expression in hematological malignancies. Leuk Lymphoma. 18:1995;61-67
230. Ginsberg A.M., Raffeld M., Cossman J. Mutations of the retinoblastoma gene in human lymphoid neoplasms. Leuk Lymphoma. 7:1992;359-362
231. Amiel A., Levi E., Reish O., Sharony R., Fejgin M.D. Replication status as a possible marker for genomic instability in cells originating from genotypes with balanced rearrangements. Chromosome Res. 9:2001;611-616
232. Korenstein-Ilan A., Amiel A., Lalezari S., Lishner M., Avivi L. Allele-specific replication associated with aneuploidy in blood cells of patients with hematologic malignancies. Cancer Genet Cytogenet. 139:2002;97-103
233. Tomlinson I.P., Lambros M.B., Roylance R.R. Loss of heterozygosity analysis: practically and conceptually flawed? Genes Chromosomes Cancer. 34:2002;349-353
234. Hsu T.C., Pathak S., Basen B.M., Stark G.J. Induction of robertsonian fusions and tandem translocations in mammalian cell cultures. Cytogenetic Cell Genet. 21:1978;86-98
235. Klein G. Specific chromosomal translocations and the genesis of B-cell derived tumors in mice and men. Cell. 32:1983;311-315
236. Multani A.S., Kacker R.K., Pathak S. Are Robertsonian translocations rare in cancers? Cancer Genet Cytogenet. 93:1997;179-180
237. Derenzini M. The AgNORs. Micron. 31:2000;117-120
238. Pich A., Chiusa L., Margaria E. Prognostic relevance of AgNORs in tumor pathology. Micron. 31:2000;133-141
239. Fonatsch C., Nowotny H., Pittermann-Hocker E., Streubel B., Jager U., Valent P., Buchner T., Lechner K. Amplification of ribosomal RNA genes in acute myeloid leukemia. Genes Chromosomes Cancer. 32:2001;11-17
240. Avet-Loiseau H., Godon C., Li J.Y., Daviet A., Mellerin M.P., Talmant P., Harousseau J.L., Bataille R. Amplification of the 11q23 region in acute myeloid leukemia. Genes Chromosomes Cancer. 26:1999;166-170
241. Streubel B., Valent P., Jager U., Edelhauser M., Wandt H., Wagner T., Buchner T., Lechner K., Fonatsch C. Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome. Genes Chromosomes Cancer. 27:2000;380-386
242. Hansemann D. Ueber asymmetrische Zelltheilung in epithel Krebsen und deren biologische Bedeutung. [On asymmetric mitoses in epithelial cancers and their biological significance]. Virschows Arch Pathol Anat. 19:1890;299-326
243. Boveri T. Zur Frage der Entstehung Maligner Tumoren [On the question of the origin of malignant tumors]. Fischer, Jena, Germany, 1914 [in German].
244. Li R., Sonik A., Stindl R., Rasnick D., Duesberg P. Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc Natl Acad Sci USA. 97:2000;3236-3241
245. Li R., Yerganian G., Duesberg P., Kraemer A., Willer A., Rausch C., Hehlmann R. Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells. Proc Natl Acad Sci USA. 94:1997;14506-14511