Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches

Biochemical Journal

Volumn 379, Issue 2, 2004, Pages 253-261

  Fleming, John V ^a   Sánchez Jiménez, Francisca ^b   Moya García, Aurelio A ^b   Langlois, Michael R ^a   Wang, Timothy C ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Histamine; Histidine decarboxylase (HDC); L amino acid decarboxylase; Site directed mutagenesis

Indexed keywords

AMINES; BIOSYNTHESIS; CARBOXYLIC ACIDS; ENZYMES; LIVING SYSTEMS STUDIES; MUTAGENESIS; PROTEINS; VITAMINS;

HISTAMINE; L-HISTIDINE DECARBOXYLASE (HDC); MUTATIONS; TRYPTIC PROTEOLYSIS;

CATALYSIS;

AMINO ACID; AROMATIC LEVO AMINO ACID DECARBOXYLASE; HISTAMINE; HISTIDINE DECARBOXYLASE; MUTANT PROTEIN; PROTEINASE; RECOMBINANT ENZYME;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; CATALYSIS; CELL LYSATE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; RAT; RETICULOCYTE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BINDING SITES; CATALYSIS; COMPUTATIONAL BIOLOGY; CYSTEINE; HISTIDINE DECARBOXYLASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TRYPSIN; TYROSINE;

MAMMALIA;

EID: 2342582122     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031525     Document Type: Article

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