A high-throughput proteo-genomics method to identify antibody targets associated with malignant disease

Clinical Immunology

Volumn 111, Issue 2, 2004, Pages 202-209

  Huang, Yinyin ^a   Franklin, Joseph ^a   Gifford, Kathreen ^a   Roberts, Bruce L ^a   Nicolette, Charles A ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Ab SCAN; antibody; spectroscopy

Indexed keywords

ANTIGEN; CANCER ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MONOCLONAL ANTIBODY; ONCOPROTEIN; PROTEIN TYROSINE KINASE; TUMOR ANTIGEN;

ANTIGEN ANTIBODY REACTION; ANTIGEN DETECTION; BREAST CANCER; CONFERENCE PAPER; DRUG TARGETING; GENE EXPRESSION PROFILING; GENOMICS; HUMAN; HUMORAL IMMUNITY; IMMUNOGENETICS; IMMUNOGENICITY; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; MASS SPECTROMETRY; MELANOMA; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEOMICS; TUMOR IMMUNITY; WESTERN BLOTTING;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PREGNANCY PROTEINS; PROSTATIC NEOPLASMS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 2342574803     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2003.12.009     Document Type: Conference Paper

References (26)

1. Miles D.W. Update on HER-2 as a target for cancer therapy: herceptin in the clinical setting. Breast Cancer Res. 3:2001;380-384
2. Grillo-López A.J., et al. Overview of the clinical development of rituximab: first monoclonal antibody approved for the treatment of lymphoma. Semin. Oncol. 26:1999;66-73
3. Mendelsohn J. Epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies. J. Natl. Cancer Inst. Monographs. 13:1992;125-131
4. Reinartz S., et al. Immunological properties of a single-chain fragment of the anti-idiotypic antibody ACA125. Cancer Immunol. Immunother. 49:2000;186-192
5. Hanai N., Nakamura K., Shitara K. Recombinant antibodies against ganglioside expressed on tumor cells. Cancer Chemother. Pharmacol. 46:2000;S13-S17. (Suppl.)
6. Juweid M.E., et al. Initial experience with high-dose radioimmunotherapy of metastatic medullary thyroid cancer using 131I-MN-14 F(ab)2 anti-carcinoembryonic antigen MAb and AHSCR. J. Nucl. Med. 41:2000;93-103
7. Sahin U., et al. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc. Natl. Acad. Sci. U. S. A. 92:1995;11810-11813
8. Miller J.C., et al. The application of protein microarrays to serum diagnostics: prostate cancer as a test case. Dis. Markers. 17:2001;225-234
9. Velculescu V.E., et al. Serial analysis of gene expression. Science. 270:1995;484-487
10. Clauser K.R., Baker P.R., Burlingame A.L. Role of accurate mass measurement (±10 ppm) in protein identification strategies employing MS or MS/MS and database searching. Anal. Chem. 71:1999;2871-2882
11. Olson L.J., Zhang J., Dahms N.M., Kim J.J. Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor. J. Biol. Chem. 277:2002;10156-10161
12. Braulke T., Causin C., Waheed A., Junghans U., Hasilik A., Maly P., Humbel R.E., von Figura K. Mannose 6-phosphate/insulin-like growth factor II receptor: distinct binding sites for mannose 6-phosphate and insulin-like growth factor II. Biochem. Biophys. Res. Commun. 150:1988;1287-1293
13. DaCosta S.A., Schumaker L.M., Ellis M.J. Mannose 6-phosphate/insulin-like growth factor 2 receptor, a bona fide tumor suppressor gene or just a promising candidate? J. Mammary Gland Biol. Neoplasia. 5:2000;85-94
14. Devi G.R., De Souza A.T., Byrd J.C., Jirtle R.L., MacDonald R.G. Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. Cancer Res. 59:1999;4314-4319
15. Tarrago D., Aguilera I., Melero J., Wichmann I., Nuñez-Roldan A., Sanchez B. Identification of cation-independent mannose 6-phosphate receptor/insulin-like growth factor type-2 receptor as a novel target of autoantibodies. Immunology. 98:1999;652-662
16. Gartung C., Braulke T., Hasilik A., von Figura K. Internalization of blocking antibodies against mannose-6-phosphate specific receptors. EMBO J. 4:1985;1725-1730
17. von Figura K., Gieselmann V., Hasilik A. Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts. EMBO J. 3:1984;1281-1286
18. Cavacini L.A. Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate-specific antigen. Clin. Cancer Res. 8:2002;368-373
19. Vanderlugt C.L., et al. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunol. Rev. 164:1998;63-72
20. Dummer R. GVAX (Cell Genesys). Curr. Opin. Investig. Drugs. 2:2001;844-848
21. Kugler A., et al. Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat. Med. 6:2000;332-336
22. Takayama T., et al. In vitro production of human antibodies specifically reactive with human gastric cancer cells of established lines and autologous tissues. J. Surg. Oncol. 36:1987;215-224
23. Salmassi A., et al. Characterization of a MAb to ovarian cancer and its possible diagnostic application. Eur. J. Gynaecol. Oncol. 20:1999;289-297
24. Czuczman M.S., Garin-Chesa P., Lemoli R.M., Scheinberg D.A. IgM monoclonal antibody JD118 recognizes an inducible antigen target for human-complement-mediated cytotoxicity against neoplastic B cells. Cancer Immunol. Immunother. 36:1993;387-396
25. Bosslet K., et al. A monoclonal antibody with binding and inhibiting activity towards human pancreatic carcinoma cells. I. Immunohistological and immunochemical characterization of a murine monoclonal antibody selecting for well differentiated adenocarcinomas of the pancreas. Cancer Immunol. Immunother. 23:1986;185-191
26. Kimmel K.A., Carey T.E. Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9. Cancer Res. 46:1986;3614-3623