Recombinant antibodies against ganglioside expressed on tumor cells

Cancer Chemotherapy and Pharmacology

Volumn 46, Issue SUPPL., 2000, Pages

  Hanai, N ^a   Nakamura, K ^a   Shitara, K ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Antibody; Cancer; Ganglioside; Lung; Melanoma

Indexed keywords

GANGLIOSIDE ANTIBODY; GANGLIOSIDE GD2; GANGLIOSIDE GD3; GANGLIOSIDE GM2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GANGLIOSIDE GD2; MONOCLONAL ANTIBODY GANGLIOSIDE GD3; MONOCLONAL ANTIBODY GANGLIOSIDE GM2; MONOCLONAL ANTIBODY KM 871; MONOCLONAL ANTIBODY KM 8969; MONOCLONAL ANTIBODY KM 966; MONOCLONAL ANTIBODY SIALYL LE A; RECOMBINANT ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; COMPLEMENT DEPENDENT CYTOTOXICITY; HUMAN; HUMAN CELL; INTERNALIZATION; LUNG SMALL CELL CANCER; MELANOMA CELL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

EID: 0033764131     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00014042     Document Type: Article

References (21)

1. Direct immobilization of gangliosides onto gold-carboxymethyldextran sensor surfaces by hydrophobic interaction: Application to antibody characterization
2. Immunization of melanoma patients with anti-idiotypic monoclonal antibody BEC2 (which mimics GD3 ganglioside): Pilot trials using no immunological adjuvant
3. Ganglioside GD2 specific monoclonal antibody 3F8: A phase-I study in patients with neuroblastoma and malignant melanoma
4. Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo
5. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: Overview and perspective
6. A phase-I study of neuroblastoma with the anti-ganglioside GD2 antibody 14.G2
7. Therapeutic efficacy of mouse-human chimeric anti-ganglioside GM2 monoclonal antibody against multiple organ micrometastases of human lung cancer in NK celldepleted scid mice
8. GM2-KLH conjugate vaccine: Increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21
9. Immunocytochemical study on internalization of anti-carbohydrate monoclonal antibodies
10. Improved survival in AJCC stage III melanoma patients with GM2 antibodies
11. A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma
12. Chimeric anti-ganglioside GM2 antibody with antitumor activity
13. Apoptosis induction of human lung cancer cell line in multicellular heterospheroids with humanized anti-ganglioside GM2 monoclonal antibody
14. Development of a human monoclonal antibody to ganglioside GM2 with potential for cancer treatment
15. Antitumor effects of a novel monoclonal antibody with high binding affinity to ganglioside GD3
16. Reshaping human antibodies for therapy
17. A mouse/human chimeric anti-(ganglioside GD3) antibody with enhanced antitumor activities
18. A new vector for the high level expression of chimeric antibodies in myeloma
19. Chromatographic separation of human brain gangliosides
20. Phase-I trial of a mouse monoclonal against GD3 ganglioside in patients with melanoma: Induction of inflammatory responses at tumor sites
21. Selection of tumor antigens as targets for immune attack using immunohistochemistory: I. Focus on gangliosides