Relationship of behavioral and psychological symptoms to cognitive impairment and functional status in Alzheimer's disease

International Journal of Geriatric Psychiatry

Volumn 15, Issue 5, 2000, Pages 393-400

  Harwood, Dylan G ^a   Barker, Warren W ^a,b   Ownby, Raymond L ^a   Duara, Ranjan ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Behavioral pathology; Cognitive impairment; Functional status

Indexed keywords

ADULT; AGED; AGGRESSIVENESS; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR; COGNITION; COGNITIVE DEFECT; DELUSION; DEMENTIA; DEPRESSION; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL DISEASE; HALLUCINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; SYMPTOM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COGNITION DISORDERS; FEMALE; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SEVERITY OF ILLNESS INDEX;

EID: 0034035287     PISSN: 08856230     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1166(200005)15:5<393::AID-GPS120>3.0.CO;2-O     Document Type: Article

References (62)

1. Alexopoulos, G. S., Vrontou, C., Kakuma, T., Kakuma, T., Meyers, B. S., Young, R. C., Klausner, E. and Clarkin, J. (1996) Disability in geriatric depression. Am. J. Psychiat. 153, 877-885.
2. Blessed, B. E., Tomlinson, B. E. and Roth, M. (1968) The association between quantitative measures of dementia and of senile change in cerebral gray matter of elderly subjects. Br. J. Psychiat. 114, 797-811.
3. Bodick, N. C., Offen, W. W., Levey, A. I., Cutler, N. R., Gauthier, S. C., Satlin, A., Shannon, H. E., Tollefson, G. D., Rasmussen, K., Bymaster, F. P., Hurley, D. J., Potter, W. Z. and Paul, S. M. (1997) Effects of xanomeline, a selective muscarinic agonist, on cognitive function and behavioral symptoms in Alzheimer's disease. Arch. Neurol. 54, 465-473.
4. Bucks, R. S., Ashworth, D. L., Wilcock, G. K. and Siegfried, K. (1996) Assessment of activities of daily living in dementia: development of the Bristol Activities of Daily Living Scale. Age Ageing 25, 113-120.
5. Burns, A., Jacoby, R. and Levy, R. (1990) Psychiatric phenomena in Alzheimer's disease. Br. J. Psychiat. 157, 72-76.
6. Burns, A., Lewis, G., Jacoby, R. and Levy, R. (1991) Factors affecting survival in Alzheimer's disease. Psychol. Med. 21, 363-370.
7. Bylsma, F. W., Folstein, M. F., Devanand, D. P., Richards, M., Bello, J., Albert, M. and Stern, Y. (1994) Delusions and pattern of cognitive impairment in Alzheimer's disease. Neuropsychiat. Neuropsychol. Behav. Neurol. 7, 98-103.
8. Chui, H. C., Lyness, S. A., Sobel, E. and Schneider, L. S. (1994) Extrapyramidal signs and psychiatric symptoms predict faster cognitive decline in Alzheimer's disease. Arch. Neurol. 51, 676-681.
9. Cummings, J. L. and Back, C. (1998) The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease. Am. J. Geriatr. Psychiat. 6(suppl. 1), 64-78.
10. Cummings, J. L., Cyrus, P. A., Ruzicka, B. B. and Gulanski, B. (1998) The efficacy of metrifonate in improving the behavioral disturbances of Alzheimer's disease patients. Neurology 50(suppl. 4), A251.
11. Deutsch, L. H., Bylsma, F. H., Rovner, B. W., Steele, C. and Folstein, M. F. (1991) Psychosis and physical aggression in probable AD. Am. J. Psychiat. 198, 1159-1163.
12. Donaldson, C., Tarrier, N. and Burns, A. (1998) Determinants of carer stress in Alzheimer's disease. Int. J. Geriatr. Psychiat. 13, 248-256.
13. Drevets, W. C. and Rubin, E. H. (1989) Psychotic symptoms and the longitudinal course of Alzheimer's disease. Biol. Psychiat. 25, 39-48.
14. Duara, R., Pascal, S., Barker, W. W., Bruce, J. and Noremberg, M. (1992) Neuropathological verification of probable and possible Alzheimer's disease (AD) [abstract]. Ann. Neurol. 32, 269.
15. Fillenbaum, G. G. and Smyer, M. (1984) The development, validity, and reliability of the OARS Multidimensional Functional Assessment Questionnaire. J. erontol. 36, 428-434.
16. Folstein, M. F., Folstein, S. and McHugh, P. R. (1975) Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189-198.
17. Forsell, Y. and Winblad, B. (1998) Major depression in a population of demented and nondemented older people: prevalence and correlates. J. Am. Geriatr. Soc. 46, 27-30.
18. Förstl, H., Burns, A., Jacoby, R. and Levy, R. (1991) Neuroanatomical correlates of clinical misidentification and misperception in senile dementia of the Alzheimer type. J. Clin. Psychiat. 52, 268-271.
19. Förstl, H., Burns, A., Luthert, P., Cairns, N., Lantos, P and Levy, R. (1992) Clinical and neuropathological correlates of depression in Alzheimer's disease. Psychol. Med. 22, 877-884.
20. Förstl, H., Burns, A., Levy, R. and Cairns, N. (1994) Neuropathological correlates of psychotic phenomenon in confirmed Alzheimer's disease. Br. J. Psychiat. 165, 53-59.
21. Greene, J. G., Smith, R., Gardiner, M. and Timbury, G. C. (1982) Measuring behavioural disturbance of elderly demented patients in the community and its effects on relatives: a factor analytic study. Age Ageing 11, 121-126.
22. Harwood, D. G., Ownby, R. L., Barker, W. W. and Duara, R. (1997) The factors structure of the Cornell Scale for Depression in Dementia among probable Alzheimer's disease patients. Am. J. Geriatr. Psychiat. 6, 212-220.
23. Harwood, D. G., Barker, W. W., Cantillon, M., Loewenstein, D. A., Ownby, R. L. and Duara, R. (1998) Depressive symptomatology in first-degree family caregivers of Alzheimer's disease patients: a cross-ethnic comparison. Alzheimer Dis. Assoc. Disord. 12, 340-346.
24. Harwood, D. G., Barker, W. W., Ownby, R. L., Bravo, M., Aguero, H. and Duara, R. Predictors of positive and negative appraisal among Cuban American caregivers of Alzheimer's disease patients. Int. J. Geriatr. Psychiat., in press.
25. Hirono, N., Mori, E., Ishii, K., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H. and Sasaki, M. (1998a) Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology 50, 380-383.
26. Hirono, N., Mori, E., Ishii, K., Kitagaki, H., Sasaki, M., Ikejiri, Y., Imamura, T., Shimomura, T., Ikeda, M. and Yamashita, H. (1998b) Alterations of regional cerebral glucose utilization with delusions in Alzheimer's disease. J. Neuropsychiat. Clin. Neurosci. 10, 433-439.
27. Jacoby, R. J. and Levy, R. (1980) Computed tomography in the elderly. 2. Senile dementia: diagnosis and functional impairment. Br. J. Psychiat. 136, 256-269.
28. Jeste, D. S., Wragg, R. E., Salmon, D. P., Harris, M. J. and Thai, L. J. (1992) Cognitive deficits of patients with Alzheimer's disease with and without delusions. Am. J. Psychiat. 149, 184-189.
29. Kaufer, D. I., Cummings, J. L. and Christine, D. (1998) Differential neuropsychiatric symptom responses to Tacrine in Alzheimer's disease: relationship to dementia severity. J. Neuropsychiat. Clin. Neurosci. 10, 55-63.
30. Kotrla, K. J., Chacko, R. C., Harper, R. G., Jhingran, S. and Doody, R. (1995) SPECT findings on psychosis in Alzheimer's disease. Am. J. Psychiat. 152, 1470-1475.
31. Lawton, M. P. and Brody, E. M. (1988a) Physical self-maintenance scale (PSMS): self-rated version. Psychopharmacol. Bull. 24, 795-797.
32. Lawton, M. P. and Brody, E. M. (1988b) Instrumental activities of daily living (IADL) scale: self-rated version. Psychopharmacol. Bull. 24, 789-791.
33. Loewenstein, D. A., Amigo, E., Duara, R., Guterman, A., Hurwitz, D., Berkowitz, N., Wilkie, F., Weinberg, G., Black, B., Gittelman, B. and Eisdorfer, C. (1989) A new scale for the assessment of functional status in Alzheimer's disease and related disorders. J. Gerontol. Psychol. Sci. 44, 114-121.
34. Loreck, D. J., Bylsma, F. W. and Folstein, M. F. (1994) The Dementia Signs and Symptoms Scale: a new scale for comprehensive assessment of psychopathology in Alzheimer's disease. Am. J. Geriatr. Psychiat. 2, 60-74.
35. Lyketsos, C. G., Steele, C., Baker, L., Galik, E., Kopunek, S. and Warren, A. (1997) Major and minor depression in Alzheimer's disease: prevalence and impact. J. Neuropsychiat. Clin. Neurosci. 9, 556-561.
36. Lyketsos, C. G., Steele, C., Galik, E., Rosenblatt, A., Steinberg, M., Warren, A. and Sheppard, J. (1999) Physical aggression in dementia patients and its relationship to depression. Am. J. Psychiat. 156, 66-71.
37. McKhann, G., Drachman, D., Folstein, M. F., Katzman, R., Price, D. and Stadlan, E. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939-944.
38. Mortimer, J. A., Ebbitt, B., Jun, S. P. and Finch, M. D. (1992) Predictors of cognitive and functional progression in patients with probable Alzheimer's disease. Neurology 42, 1689-1696.
39. Pearson, J. L., Teri, L., Reifler, B. V. and Raskind, M. A. (1989) Functional status and cognitive impairment in Alzheimer's patients with and without depression. J. Am. Geriatr. Soc. 37, 1117-1121.
40. Pontón, M. O., Darcourt, J., Miller, B. L., Cummings, J. L., Schumann, S. W. and Maen, I. (1995) Psychometric and SPECT studies in Alzheimer's disease with and without delusions. Neuropsychiat. Neuropsychol. Behav. Neurol. 8, 264-270.
41. Reisberg, B., Borenstein, J., Salob, S. P., Ferris, S. H., Franssen, E. and Georgotas, A. (1987) Behavioral symptoms in Alzheimer's disease: phenomenology and treatment. J. Clin. Psychiat. 48(suppl. 5), 9-15.
42. Reisberg, B., Franssen, E., Sclan, S. G., Kluger, A. and Ferris, S. H. (1989) Stage specific incidence of potentially remediable behavioral symptoms in aging and Alzheimer's disease. Bull. Clin. Neurosci. 54, 95-112.
43. Rockwell, E., Jackson, E., Vilke, G. and Jeste, D. V. (1994) A study of delusions in a large cohort of Alzheimer's disease patients. Am. J. Geriatr. Psychiat. 2, 157-164.
44. Rosen, J. and Zubenko, G. S. (1991) Emergence of psychosis and depression in the longitudinal evaluation of Alzheimer's disease. Biol. Psychiat. 29, 224-232.
45. Rovner, B. W., Broadhead, J., Spencer, M., Carson, K. and Folstein, M. F. (1989) Depression and Alzheimer's disease. Am. J. Psychiat. 146, 350-353.
46. Starkstein, S. E., Vazquez, S., Petracca, G., Sabe, L., Migliorelli, R., Tesón, A. and Leiguarda, R. (1994) A SPECT study of delusions in Alzheimer's disease. Neurology 44, 2055-2059.
47. Starkstein, S. E., Vazquez, S., Migliorelli, R., Teson, A., Petracca, G. and Leiguarda, R. (1995) A SPECT study of depression in Alzheimer's disease. Neuropsychiat. Neuropsychol. Behav. Neurol. 8, 38-43.
48. Steele, C., Rovner, B., Chase, G. A. and Folstein, M. F. (1990) Psychiatric problems and nursing home placement of patients with Alzheimer's disease. Am. J. Psychiat. 147, 1049-1051.
49. Stern, Y., Hesdorffer, D., Sano, M and Mayeux, R. (1990) Measurement and prediction of functional capacity in Alzheimer's Disease. Neurology 40, 8-14.
50. Sultzer, D. L., Levin, H. S., Mahler, M. E., High, W. M. and Cummings, J. L. (1992) Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale. J. Am. Geriatr. Soc. 40, 549-555.
51. Sultzer, D. L., Mahler, M. E., Mandelkern, M. A., Van Gorp, W. G., Hinkin, C. H. and Berisford, M. A. (1995) The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's Disease. J. Neuropsychiat. Clin. Neurosci. 1, 476-484.
52. Teri, L. and Wagner, A. (1991) Assessment of depression in patients with Alzheimer's disease: concordance among informants. Psychol. Aging 6, 280-285.
53. Teri, L., Traux, P., Logsdon, R., Uomoto, J., Zarit, S. and Vitaliano, P. P. (1992) Assessment of behavioral problems in dementia: the revised memory and behavior problem checklist. Psychol. Aging 7, 622-631.
54. Vasterling, J. J., Seltzer, B., Foss, J. W. and Vanderbrook, V. (1995) Unawareness of deficit in Alzheimer's disease: domain-specific differences and disease correlates. Neuropsychiat. Neuropsychol. Behav. Neurol. 8, 26-32.
55. Victoroff, J., Zarrow, C., Mack, W. J., Hsu, E. and Chui, H. C. (1996) Physical aggression is associated with preservation of substantia nigra pars compacta in Alzheimer's disease. Arch. Neurol. 53, 428-434.
56. Walsh, J. S., Welch, H. G. and Larson, E, B. (1990) Survival of outpatients with Alzheimer-type dementia. Ann. Intern. Med. 113, 429-434.
57. Zanetti, O., Geroldi, C., Frisoni, G. B., Bianchetti, A. and Trabucchi, M. (1999) Contrasting results between caregiver's report and direct assessment of activities of daily living in patients affected by mild and very mild dementia: the contribution of the caregiver's personal characteristics. J. Am. Geriatr. Soc. 47, 196-202.
58. Zee, R. F. (1993) Neuropsychological function in Alzheimer's disease. In Neuropsychology of Alzheimer 's Disease and Other Dementias (R. W. Parks, R. F. Zee and R. S. Wilson, Eds). Oxford University Press, New York, pp. 3-80.
59. Zubenko, G. S. and Moossy, J. (1988) Major depression in primary dementia: clinical and neuropathologic correlates. Arch. Neurol. 45, 1182-1186.
60. Zubenko, G. S., Moossy, J. and Kopp, U. (1990) Neurochemical correlates of major depression in primary dementia. Arch. Neurol. 47, 209-214.
61. Zubenko, G. S., Moossy, J., Martinez, A. J., Rao, G., Claasen, D., Rosen, J. and Kopp, U. (1991) Neuropathologic and neurochemical correlates of psychosis in primary dementia. Arch. Neurol. 48, 619-624.
62. Zweig, R. M., Ross, C. A., Hedreen, J. C., Steele, C., Cardillo, J. E., Whitehouse, P. J., Folstein, M. F. and Price, D. L. (1988) The neuropathology of aminergic nuclei in Alzheimer's disease. Ann. Neurol. 24, 233-242.