Separation of glutathione and its related amino acids by nanofiltration

Biochemical Engineering Journal

Volumn 19, Issue 2, 2004, Pages 165-170

  Gotoh, Takeshi ^a   Iguchi, Hisashi ^a   Kikuchi, Ken Ichi ^a  

^a AKITA UNIVERSITY   (Japan)

Author keywords

Enzymatic peptide synthesis; Equilibrium control; Glutathione synthesis; Membrane

Indexed keywords

AMINO ACIDS; CONCENTRATION (PROCESS); ELECTROLYTES; ENZYMES; PH EFFECTS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ENZYMATIC GLUTATHIONE SYNTHESIS; NANOFILTRATION MEMBRANE; REACTION EQUILIBRIA;

NANOFILTRATION;

AMINO ACID; CYSTEINE; ELECTROLYTE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLYCINE; METAL ION;

ARTICLE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; GLUTATHIONE METABOLISM; MEMBRANE; NANOFILTRATION; PH; PRIORITY JOURNAL; REACTION ANALYSIS; SEPARATION TECHNIQUE;

EID: 2342515282     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2003.12.011     Document Type: Article

References (21)

1. Weber G.F. Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. Neurosci. Biobehav. Rev. 23:1999;1079-1086
2. Kidd P.M. Glutathione: systemic protectant against oxidative and free radical damage. Altern. Med. Rev. 1:1997;155-176
3. Meister A., Tate S.S. Glutathione and related γ-glutamyl compounds: biosynthesis and utilization. Annu. Rev. Biochem. 45:1976;559-604
4. Sakato K., Tanaka H. Advanced control of glutathione fermentation process. Biotechnol. Bioeng. 40:1992;904-912
5. R. Nakayama, Thesis, Kyoto University, 1984.
6. Nakanishi K., Matsuno R. Recent developments in enzymatic synthesis of peptide. Adv. Biotechnol. Process. 10:1989;173-202
7. A. Meister, Metabolic pathways, in: M.D. Greenberg (Ed.), Metabolism of Sulfur Compounds, third ed., vol. 7, Academic Press, New York, pp. 101-188.
8. Gotoh T., Watanabe M., Iwanaga T., Kikuchi K.-I. Glutathione production by reversible sequential reactions of γ-glutamyl transpeptidase and aminopeptidase M co-immobilized in gel beads via liposome confinement. Proc. 5th World Cong. Chem. Eng. 2:1996;376-380
9. R.D. Allison, γ-Glutamyl transpeptidase: kinetics and mechanism, in: A. Meister, S.P. Colowick, A.O. Kaplan (Eds.), Glutamate, glutamine, glutathione, and related compounds, Method Enzymol. 113 (1986) 419-437.
10. Kozak E.M., Tate S.S. Glutathione-degrading enzymes of microvillus membranes. J. Biol. Chem. 257:1982;6322-6327
11. Okajima K., Inoue M., Morino Y. Topology and some properties of the renal brush border membrane-bound peptidase(s) participating in the metabolism of S-carbamidomethyl glutathione. Biochim. Biophys. Acta. 675:1981;379-385
12. T. Gotoh, M. Takahashi, H. Takahashi, K.-I. Kikuchi, Electrodialytic separation of glutathione and glutamic acid, Scientific and Technical Reports of the Mining College, Akita University, vol. 15, 1994, pp. 23-28.
13. Gotoh T., Kikuchi K.-I. Contamination of an anion-exchange membrane by glutathione. Bioseparation. 9:2000;37-41
14. Wang X.-L., Ying A.-L., Wang W.-N. Nanofiltration of L-phenylalanine and L-aspartic acid aqueous solutions. J. Membr. Sci. 196:2002;59-67
15. Martin-Orue C., Bouhallab S., Garem A. Nanofiltration of amino acid and peptide solutions: mechanisms of separation. J. Membr. Sci. 142:1998;225-233
16. Timmer J.M.K., Speelmans M.P.J., van der Horst H.C. Separation of amino acids by nanofiltration and ultrafiltration membranes. Sep. Purifi. Technol. 14:1998;133-144
17. Tsuru T., Shutou T., Nakano S.-I., Kmura S. Peptide and amino acid separation with nanofiltration membranes. Sep. Sci. Technol. 29:1994;971-984
18. Kikuchi K.-I., Miyata S., Takahashi H., Gotoh T., Sugawara T., Dranoff J.S. Sorption of amino acids by ion exchange membranes. J. Chem. Eng. Jpn. 27:1994;391-398
19. Goodman L., Ross L.O., Baker B.R. Potential anticancer agents V. Some sulfur-substituted derivatives of cysteine. J. Org. Chem. 23:1958;1251-1257
20. Levina A., Zhang L., Lay P.A. Structure and reactivity of a chromium (V) glutathione complex. Inorg. Chem. 42:2003;767-784
21. Gotoh T., Shidara M., Iwanaga T., Kikuchi K.-I. Immobilization of γ-glutamyl transpeptidase, a membrane enzyme, in gel beads via liposome entrapment. J. Ferment. Bioeng. 77:1994;268-273