Postpartum onset obsessive-compulsive disorder: Diagnosis and management

Archives of Women's Mental Health

Volumn 7, Issue 2, 2004, Pages 99-110

  Brandes, Mina ^a   Soares, C N ^a   Cohen, L S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Breastfeeding; Diagnosis; Management; Obsessive compulsive disorder; Postpartum

Indexed keywords

ANTIDEPRESSANT AGENT; BUSPIRONE; CARBAMAZEPINE; CITALOPRAM; CLOMIPRAMINE; DESIPRAMINE; ESTRADIOL; FLUOXETINE; FLUVOXAMINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE;

ADOLESCENT; ADULT; BEHAVIOR THERAPY; BREAST FEEDING; BREAST MILK; CLINICAL ARTICLE; COGNITIVE THERAPY; CONTROLLED STUDY; DRUG MILK LEVEL; DRUG SAFETY; ESTROGEN DEFICIENCY; FEMALE; HUMAN; MAJOR DEPRESSION; MENTAL DISEASE; OBSESSIVE COMPULSIVE DISORDER; PREGNANCY; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; PSYCHOPHARMACOTHERAPY; PUERPERAL DEPRESSION; PUERPERAL PSYCHOSIS; PUERPERIUM; REVIEW; SCREENING TEST; SIDE EFFECT;

BREAST FEEDING; FEMALE; HEALTH SERVICES RESEARCH; HUMANS; INCIDENCE; OBSESSIVE-COMPULSIVE DISORDER; POSTPARTUM PERIOD; PREVALENCE; SEROTONIN UPTAKE INHIBITORS; UNITED STATES;

EID: 2342455089     PISSN: 14341816     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00737-003-0035-3     Document Type: Review

References (149)

1. Abramowitz J, Moore K, Carmin C, Wiegartz PS, Purdon C (2001) Acute onset of obsessive-compulsive disorder in males following childbirth. Psychosomatics 42: 429-431.
2. Ahokas A, Aito M, Turiainen S (2000) Association between oestradiol and puerperal psychosis. Acta Psychiatr Scand 101: 167-169; discussion 169-170.
3. Ahokas A, Kaukoranta J, Wahlbeck K, Aito M (2001) Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. J Clin Psychiatry 62: 332-336.
4. Albert U, Aguglia E, Maina G, Bogetto F (2002a) Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study. J Clin Psychiatry 63: 1004-1009.
5. Albert U, Bergesio C, Pessina E, Maina G, Bogetto F (2002b) Management of treatment resistant obsessive-compulsive disorder. Algorithms for pharmacotherapy. Panminerva Med 44: 83-91.
6. Altshuler LL, Burt VK, McMullen M, Hendrick V (1995) Breastfeeding and sertraline: a 24-hour analysis. J Clin Psychiatry 56: 243-245.
7. Altshuler LL, Hendrick V, Cohen LS (1998) Course of mood and anxiety disorders during pregnancy and the postpartum period. J Clin Psychiatry 59 Suppl. 2: 29-33.
8. American Academy of Pediatrics (1997) Breastfeeding and the use of human milk. American Academy of Pediatrics. Work Group on Breastfeeding. Pediatrics 100: 1035-1039.
9. American Academy of Pediatrics Committee on Drugs (2001) Transfer of drugs and other chemicals into human milk. Pediatrics 108: 776-789.
10. Ananth J, Burgoyne K, Smith M, Swartz R (1995) Venlafaxine for treatment of obsessive-compulsive disorder. Am J Psychiatry 152: 1832.
11. Anderson PO (1991) Drug use during breast-feeding. Clin Pharm 10: 594-624.
12. Arnold LM (1999) A case series of women with postpartum-onset obsessive-compulsive disorder. Primary Care Companion. J Clin Psychiatry 1: 103-108.
13. Arnold AF, Baugh C, Fisher A, Brown J, Stowe ZN (2002) Psychiatric Aspects of the Postpartum Period. In: Women's mental health: a comprehensive textbook, 1st edn, The Guilford Press, New York, pp 91-113.
14. Barr LC, Goodman WK, Price LH (1993) The serotonin hypothesis of obsessive compulsive disorder. Int Clin Psychopharmacol 8 Suppl 2: 79-82.
15. Bebbington PE (1998) Epidemiology of obsessive-compulsive disorder. Br J Psychiatry Suppl: 2-6.
16. Begg EJ, Duffull SB, Saunders DA, Buttimore RC, Ilett KF, Hackett LP, Yapp P, Wilson DA (1999) Paroxetine in human milk. Br J Clin Pharmacol 48: 142-147.
17. Biegon A, Reches A, Snyder L, McEwen BS (1983) Serotonergic and noradrenergic receptors in the rat brain: modulation by chronic exposure to ovarian hormones. Life Sci 32: 2015-2021.
18. Birnbaum CS, Cohen LS, Bailey JW, Grush LR, Robertson LM, Stowe ZN (1999) Serum concentrations of antidepressants and benzodiazepines in nursing infants: A case series. Pediatrics 104: e11.
19. Brent NB, Wisner KL (1998) Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair. Clin Pediatr (Phila) 37: 41-44.
20. Brockington IF, Cernik KF, Schofield EM, Downing AR, Francis AF, Keelan C (1981) Puerperal Psychosis. Phenomena and diagnosis. Arch Gen Psychiatry 38: 829-833.
21. Burch KJ, Wells BG (1992) Fluoxetine/norfluoxetine concentrations in human milk. Pediatrics 89: 676-677.
22. Burt VK, Suri R, Altshuler L, Stowe Z, Hendrick VC, Muntean E (2001) The use of psychotropic medications during breast-feeding. Am J Psychiatry 158: 1001-1009.
23. Buttolph ML, Holland A (1990) Obsessive compulsive disorders in pregnancy and childbirth. In: Obsessive compulsive disorders, theory and management, 1st edn. Yearbook Medical Publishers, Chicago, Ill.
24. Button JH, Reivich RS (1972) Obsessions of infanticide. A review of 42 cases. Arch Gen Psychiatry 27: 235-240.
25. Bystritsky A, Ackerman DL, Rosen RM, Vapnik T, Gorbis E, Maidmant KM, Saxena S (2001) Augmentation of SSRI response in refractory OCD using adjunctive olanzapine: a placebo-controlled trial. Presented at the Fifth International Obsessive-Compulsive Disorder Conference, Sardinia, Italy, March 29-April 1, 2001.
26. Chambers CD, Johnson KA, Dick LM, Felix RJ, Jones KL (1996) Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 335: 1010-1015.
27. Chambers CD, Anderson PO, Thomas RG, Dick LM, Felix RJ, Johnson KA, Jones KL (1999) Weight gain in infants breastfed by mothers who take fluoxetine. Pediatrics 104: e61.
28. Chelmow D, Halfin VP (1997) Pregnancy complicated by obsessive-compulsive disorder. J Matern Fetal Med 6: 31-34.
29. Chua S, Arulkumaran S, Lim I, Selamat N, Ratnam SS (1994) Influence of breastfeeding and nipple stimulation on postpartum uterine activity. Br J Obstet Gynaecol 101: 804-805.
30. Cogill SR, Caplan HL, Alexandra H, Robson KM, Kumar R (1986) Impact of maternal postnatal depression on cognitive development of young children. Br Med J (Clin Res Ed) 292: 1165-1167.
31. Cohen LS, Altshuler LL (1997) Pharmacologic management of psychiatric illness during pregnancy and the postpartum period. In: Psychiatric Clinics of North America Annual of Drug Therapy, 1st edn. Saunders, Philadelphia, pp 21-61.
32. Cohen LS, Heller VL, Bailey JW, Grush L, Ablon JS, Bouffard SM (2000) Birth outcomes following prenatal exposure to fluoxetine. Biol Psychiatry 48: 996-1000.
33. Cone RI, Davis GA, Goy RW (1981) Effects of ovarian steroids on serotonin metabolism within grossly dissected and microdissected brain regions of the ovariectomized rat. Brain Res Bull 7: 639-644.
34. Costei AM, Kozer E, Ho T, Ito S, Koren G (2002) Perinatal outcome following third trimester exposure to paroxetine. Arch Pediatr Adolesc Med 156: 1129-1132.
35. Cummings EM, Davies PT (1994) Maternal depression and child development. J Child Psychol Psychiatry 35: 73-112.
36. Dannon PN, Sasson Y, Hirschmann S, Iancu I, Grunhaus U, Zohar J (2000) Pindolol augmentation in treatment-resistant obsessive compulsive disorder: a double-blind placebo controlled trial. Eur Neuropsychopharmacol 10: 165-169.
37. Davidson J, Robertson E (1985) A follow-up study of post partum illness, 1946-1978. Acta Psychiatr Scand 71: 451-457.
38. DeVeaugh-Geiss J, Katz R, Landau P et al. (1991) Clomipramine in the treatment of patients with obsessive-compulsive disorder. The Clomipramine Collaborative Study Group. Arch Gen Psychiatry 48: 730-738.
39. Ehrenkranz JR (1976) Effects of sex steroids on serotonin uptake in blood platelets. Acta Endocrinol (Copenh) 83: 420-428.
40. Epperson CN, McDougle CJ, Brown RM, Leckman JF, Goodman WK, Price LH (1995) OCD during pregnancy and the puerperium. American Psychiatric Association New Research Abstract #NR112: 84.
41. Epperson CN, Anderson GM, McDougle CJ (1997) Sertraline and breast-feeding. N Engl J Med 336: 1189-1190.
42. Epperson N, Czarkowski KA, Ward OBD, Weiss E, Gueorguieva R, Jatlow P, Anderson GM (2001) Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs. Am J Psychiatry 158: 1631-1637.
43. Field T (1998) Maternal depression effects on infants and early interventions. Prev Med 27: 200-203.
44. Gelenberg AJ (1995) Fluoxetine labeling revised. Biol Ther Psychiatry Newsl 18: 1.
45. Geller PA, Klier CM, Neugebauer R (2001) Anxiety disorders following miscarriage. J Clin Psychiatry 62: 432-438.
46. Gold LH (2002) Postpartum disorders in primary care: diagnosis and treatment. Prim Care 29: 27-41, vi.
47. Goldstein DJ (1995) Effects of third trimester fluoxetine exposure on the newborn. J Clin Psychopharmacol 15: 417-420.
48. Goldstein DJ, Corbin LA, Sundell KL (1997) Effects of first-trimester fluoxetine exposure on the newborn. Obstet Gynecol 89: 713-718.
49. Goodman WK (1999) Obsessive-compulsive disorder: diagnosis and treatment. J Clin Psychiatry 60 Suppl 18: 27-32.
50. Goodman WK, Price LH, Rasmussen SA, Delgado PL, Heninger GR, Charney DS (1989a) Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. Arch Gen Psychiatry 46: 36-44.
51. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, Charney DS (1989b) The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 46: 1012-1016.
52. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS (1989c) The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 46: 1006-1011.
53. Greist J, Chouinard G, DuBoff E, Halaris A, Kim SW, Koran L, Liebowitz M, Lydiard RB, Rasmussen S, White K et al. (1995) Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder. Arch Gen Psychiatry 52: 289-295.
54. Greist JH, Jefferson JW (1998) Pharmacotherapy for obsessive-compulsive disorder. Br J Psychiatry Suppl: 64-70.
55. Grossman R, Hollander E (1996) Treatment of obsessive-compulsive disorder with venlafaxine. Am J Psychiatry 153: 576-577.
56. Hendrick V, Stowe ZN, Altshuler LL, Hostetter A, Fukuchi A (2000) Paroxetine use during breast-feeding. J Clin Psychopharmacol 20: 587-589.
57. Hendrick V, Altshuler L, Wertheimer A, Dunn WA (2001a) Venlafaxine and breast-feeding. Am J Psychiatry 158: 2089-2090.
58. Hendrick V, Fukuchi A, Altshuler L, Widawski M, Wertheimer A, Brunhuber MV (2001b) Use of sertraline, paroxetine and fluvoxamine by nursing women. Br J Psychiatry 179: 163-166.
59. Hendrick V, Stowe ZN, Altshuler LL, Mintz J, Hwang S, Hostetter A, Suri R, Leight K, Fukuchi A (2001c) Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. Biol Psychiatry 50: 775-782.
60. Hertzberg T, Leo RJ, Kim KY (1997) Recurrent obsessive-compulsive disorder associated with pregnancy and childbirth. Psychosomatics 38: 386-388.
61. Hollander E, Bienstock CA, Koran LM, Pallanti S, Marazziti D, Rasmussen SA, Ravizza L, Benkelfat C, Saxena S, Greenberg BD, Sasson Y, Zohar J (2002) Refractory obsessive-compulsive disorder: state-of-the-art treatment. J Clin Psychiatry 63: 20-29.
62. Ilett KF, Kristensen JH, Hackett LP, Paech M, Kohan R, Rampono J (2002) Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants. Br J Clin Pharmacol 53: 17-22.
63. Ingram IM (1961) Obsessional illness in mental hospital patients. J Ment Sci 107: 382-402.
64. Isenberg KE (1990) Excretion of fluoxetine in human breast milk. J Clin Psychiatry 51: 169.
65. Jenike MA (2001) An update on obsessive-compulsive disorder. Bull Menninger Clin 65: 4-25.
66. Jennings KD, Ross S, Popper S, Elmore M (1999) Thoughts of harming infants in depressed and nondepressed mothers. J Affect Disord 54: 21-28.
67. Jensen PN, Olesen OV, Bertelsen A, Linnet K (1997) Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant. Ther Drug Monit 19: 236-239.
68. Kamo M, Golding JM, Sorenson SB, Burnam MA (1988) The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry 45: 1094-1099.
69. Kendell RE, McGuire RJ, Connor Y, Cox JL (1981) Mood changes in the first three weeks after childbirth. J Affect Disord 3: 317-326.
70. Kendell RE, Chalmers JC, Platz C (1987) Epidemiology of puerperal psychoses. Br J Psychiatry 150: 662-673.
71. Kim MS, Park SJ, Shin MS, Kwon JS (2002) Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment. J Psychiatr Res 36: 257-265.
72. Knops GG (1993) Postpartum mood disorders. A startling contrast to the joy of birth. Postgrad Med 93: 103-104, 109-110, 113-116.
73. Koponen H, Lepola U, Leinonen E, Jokinen R, Penttinen J, Turtonen J (1997) Citalopram in the treatment of obsessive-compulsive disorder: an open pilot study. Acta Psychiatr Scand 96: 343-346.
74. Kristensen JH, Ilett KF, Dusci LJ, Hackett LP, Yapp P, Wojnar-Horton RE, Roberts MJ, Paech M (1998) Distribution and excretion of sertraline and N-desmethylsertraline in human milk. Br J Clin Pharmacol 45: 453-457.
75. Kristensen JH, Ilett KF, Hackett LP, Yapp P, Paech M, Begg EJ (1999) Distribution and excretion of fluoxetine and norfluoxetine in human milk. Br J Clin Pharmacol 48: 521-527.
76. Kumar R, Robson KM (1984) A prospective study of emotional disorders in childbearing women. Br J Psychiatry 144: 35-47.
77. Lester BM, Cucca J, Andreozzi L, Flanagan P, Oh W (1993) Possible association between fluoxetine hydrochloride and colic in an infant. J Am Acad Child Adolesc Psychiatry 32: 1253-1255.
78. Lo WH (1967) A follow-up study of obsessional neurotics in Hong Kong Chinese. Br J Psychiatry 113: 823-832.
79. Maina G, Albert U, Bogetto F, Vaschetto P, Ravizza L (1999) Recent life events and obsessive-compulsive disorder (OCD): the role of pregnancy/delivery. Psychiatry Res 89: 49-58.
80. Maina G, Albert U, Bogetto F (2001) Relapses after discontinuation of drug associated with increased resistance to treatment in obsessive-compulsive disorder. Int Clin Psychopharmacol 16: 33-38.
81. Mammen OK, Perel JM, Rudolph G, Foglia JP, Wheeler SB (1997) Sertraline and norsertraline levels in three breastfed infants. J Clin Psychiatry 58: 100-103.
82. Marazziti D, Dell'Osso L, Gemignani A, Ciapparelli A, Presta S, Nasso ED, Pfanner C, Cassano GB (2001) Citalopram in refractory obsessive-compulsive disorder: an open study. Int Clin Psychopharmacol 16: 215-219.
83. March JS, Frances A, Carpenter D, Kahn D (1997) Treatment of obsessive-compulsive disorder. The Expert Consensus Panel for obsessive-compulsive disorder. J Clin Psychiatry 58 Suppl 4: 2-72.
84. McDougle CJ, Barr LC, Goodman WK, Price LH (1999) Possible role of neuropeptides in obsessive compulsive disorder. Psychoneuroendocrinology 24: 1-24.
85. McDougle CJ, Epperson CN, Pelton GH, Wasylink S, Price LH (2000) A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 57: 794-801.
86. McDonough M, Kennedy N (2002) Pharmacological management of obsessive-compulsive disorder: a review for clinicians. Harv Rev Psychiatry 10: 127-137.
87. Misri S, Sivertz K (1991) Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med 21: 157-171.
88. Misri S, Kim J, Riggs KW, Kostaras X (2000) Paroxetine levels in postpartum depressed women, breast milk, and infant serum. J Clin Psychiatry 61: 828-832.
89. Montgomery SA, Montgomery DB, Fineberg N (1990) Early response with clomipramine in obsessive compulsive disorder - a placebo controlled study. Prog Neuropsychopharmacol Biol Psychiatry 14: 719-727.
90. Montgomery SA, Kasper S, Stein DJ, Bang Hedegaard K, Lemming OM (2001) Citalopram 20 mg, 40 mg and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder. Int Clin Psychopharmacol 16: 75-86.
91. Murray L, Cooper P (1997) Effects of postnatal depression on infant development. Arch Dis Child 77: 99-101.
92. Nestadt G, Samuels J, Riddle M, Bienvenu OJ, 3rd, Liang KY, LaBuda M, Walkup J, Grados M, Hoehn-Saric R (2000) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 57: 358-363.
93. Newcomb PA, Storer BE, Longnecker MP, Mittendorf R, Greenberg ER, Clapp RW, Burke KP, Willett WC, MacMahon B (1994) Lactation and a reduced risk of premenopausal breast cancer. N Engl J Med 330: 81-87.
94. Neziroglu F, Anemone R, Yaryura-Tobias JA (1992) Onset of obsessive-compulsive disorder in pregnancy. Am J Psychiatry 149: 947-950.
95. Nonacs R, Cohen LS (1998) Postpartum mood disorders: diagnosis and treatment guidelines. J Clin Psychiatry 59 Suppl 2: 34-40.
96. Nonacs R, Cohen LS (2002) Depression during pregnancy: diagnosis and treatment options. J Clin Psychiatry 63 Suppl 7: 24-30.
97. Nulman I, Rovet J, Stewart DE, Wolpin J, Gardner HA, Theis JG, Kulin N, Koren G (1997) Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 336: 258-262.
98. Nulman I, Rovet J, Stewart DE, Wolpin J, Pace-Asciak P, Shuhaiber S, Koren G (2002) Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry 159: 1889-1895.
99. Ohman R, Hagg S, Carleborg L, Spigset O (1999) Excretion of paroxetine into breast milk. J Clin Psychiatry 60: 519-523.
100. O'Sullivan G, Noshirvani H, Marks I, Monteiro W, Lelliott P (1991) Six-year follow-up after exposure and clomipramine therapy for obsessive compulsive disorder. J Clin Psychiatry 52: 150-155.
101. Overbeek T, Schruers K, Vermetten E, Griez E (2002) Comorbidity of obsessive-compulsive disorder and depression: prevalence, symptom severity, and treatment effect. J Clin Psychiatry 63: 1106-1112.
102. Paffenbarger RA (1982) Epidemiological aspects of mental illness associated with childbearing, in motherhood and mental illness, 1st edn. Grune & Stratton, New York, pp 19-36.
103. Pastuszak A, Schick-Boschetto B, Zuber C, Feldkamp M, Pinelli M, Sihn S, Donnenfeld A, McCormack M, Leen-Mitchell M, Woodland C et al. (1993) Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac). Jama 269: 2246-2248.
104. Pauls DL, Alsobrook JP, 2nd, Goodman W, Rasmussen S, Leckman JF (1995) A family study of obsessive-compulsive disorder. Am J Psychiatry 152: 76-84.
105. Peindl KS, Zolnik EJ, Wisner KL, Hanusa BH (1995) Effects of postpartum psychiatric illnesses on family planning. Int J Psychiatry Med 25: 291-300.
106. Pigott TA (2002) Anxiety disorders. In: Women's Mental Health: a comprehensive textbook, 1st edn. Guilford Press, New York, pp 195-221.
107. Piontek CM, Wisner KL, Perel JM, Peindl KS (2001) Serum fluvoxamine levels in breastfed infants. J Clin Psychiatry 62: 111-113.
108. Pitt B (1982) Depression and childbirth. In: Handbook of affective disorders, 1st edn. Guilford Press, New York.
109. Pollitt J (1957) Natural history of obsessional states. Br Med J 1: 194-198.
110. Rachman S (1997) A cognitive theory of obsessions. Behav Res Ther 35: 793-802.
111. Rampono J, Kristensen JH, Hackett LP, Paech M, Kohan R, Bert KF (2000) Citalopram and demethylcitalopram in human milk; distribution, excretion and effects in breast fed infants. Br J Clin Pharmacol 50: 263-268.
112. Rasmussen SA, Tsuang MT (1986) Clinical characteristics and family history in DSM-III obsessive-compulsive disorder. Am J Psychiatry 143: 317-322.
113. Rasmussen SA, Eisen JL (1994) The epidemiology and differential diagnosis of obsessive compulsive disorder. J Clin Psychiatry 55 Suppl: 5-10; discussion 11-14.
114. Rauch SL, RL OS, Jenike MA (1996) Open treatment of obsessive-compulsive disorder with venlafaxine: a series of ten cases. J Clin Psychopharmacol 16: 81-84.
115. Rauch SL (2000) Neuroimaging research and the neurobiology of obsessive-compulsive disorder: where do we go from here? Biol Psychiatry 47: 168-170.
116. Renner KJ, Krey LC, Luine VN (1987) Effect of progesterone on monoamine turnover in the brain of the estrogen-primed rat. Brain Res Bull 19: 195-202.
117. Robins LN, Helzer JE, Weissman MM, Orvaschel H, Gruenberg E, Burke JD Jr, Regier DA (1984) Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry 41: 949-958.
118. Savage CR, Deckersbach T, Wilhelm S, Rauch SL, Baer L, Reid T, Jenike MA (2000) Strategic processing and episodic memory impairment in obsessive compulsive disorder. Neuropsychology 14: 141-151.
119. Saxena S, Brody AL, Schwartz JM, Baxter LR (1998) Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl: 26-37.
120. Schimmell MS, Katz EZ, Shaag Y, Pastuszak A, Koren G (1991) Toxic neonatal effects following maternal clomipramine therapy. J Toxicol Clin Toxicol 29: 479-484.
121. Schmidt K, Olesen OV, Jensen PN (2000) Citalopram and breastfeeding: serum concentration and side effects in the infant. Biol Psychiatry 47: 164-165.
122. Sevincok L, Uygur B (2002) Venlafaxine open-label treatment of patients with obsessive-compulsive disorder. Aust N Z J Psychiatry 36: 817.
123. Shear MK, Mammen O (1995) Anxiety disorders in pregnant and postpartum women. Psychopharmacol Bull 31: 693-703.
124. Sichel DA, Cohen LS, Dimmock JA, Rosenbaum JF (1993a) Postpartum obsessive compulsive disorder: a case series. J Clin Psychiatry 54: 156-159.
125. Sichel DA, Cohen LS, Rosenbaum JF, Driscoll J (1993b) Postpartum onset of obsessive-compulsive disorder. Psychosomatics 34: 277-279.
126. Spigset O, Carleborg L, Norstrom A, Sandlund M (1996) Paroxetine level in breast milk. J Clin Psychiatry 57: 39.
127. Spigset O, Carieborg L, Ohman R, Norstrom A (1997) Excretion of citalopram in breast milk. Br J Clin Pharmacol 44: 295-298.
128. Stein A, Gath DH, Bucher J, Bond A, Day A, Cooper PJ (1991) The relationship between post-natal depression and mother-child interaction. Br J Psychiatry 158: 46-52.
129. Stockert M, De Robertis E (1985) Effect of ovariectomy and estrogen on [3H]imipramine binding to different regions of rat brain. Eur J Pharmacol 119: 255-257.
130. Stowe ZN, Owens MJ, Landry JC, Kilts CD, Ely T, Llewellyn A, Nemeroff CB (1997) Sertraline and desmethylsertraline in human breast milk and nursing infants. Am J Psychiatry 154: 1255-1260.
131. Stowe ZN, Cohen LS, Hostetter A, Ritchie JC, Owens MJ, Nemeroff CB (2000) Paroxetine in human breast milk and nursing infants. Am J Psychiatry 157: 185-189.
132. Stowe ZN, Hostetter AL, Owens MJ, Ritchie JC, Sternberg K, Cohen LS, Nemeroff CB (2003) The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. J Clin Psychiatry 64: 73-80.
133. Taddio A, Ito S, Koren G (1996) Excretion of fluoxetine and its metabolite, norfluoxetine, in human breast milk. J Clin Pharmacol 36: 42-47.
134. Thoren P, Asberg M, Cronholm B, Jornestedt L, Traskman L (1980) Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial. Arch Gen Psychiatry 37: 1281-1285.
135. Tollefson GD, Rampey AH Jr, Potvin JH, Jenike MA, Rush AJ, Kominguez RA, Koran LM, Shear MK, Goodman W, Genduso LA (1994) A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder. Arch Gen Psychiatry 51: 559-567.
136. Weinberg MK, Tronick EZ (1998) Emotional characteristics of infants associated with maternal depression and anxiety. Pediatrics 102: 1298-1304.
137. Weissman MM, Bland RC, Canino GJ, Greenwald S, Hwu HG, Lee CK, Newman SC, Oakley-Browne MA, Rubio-Stipec M, Wickramaratne PJ et al. (1994) The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. J Clin Psychiatry 55 Suppl: 5-10.
138. Williams KE, Koran LM (1997) Obsessive-compulsive disorder in pregnancy, the puerperium, and the premenstruum. J Clin Psychiatry 58: 330-334; quiz 335-336.
139. Wisner KL, Perel JM, Foglia JP (1995) Serum clomipramine and metabolite levels in four nursing mother-infant pairs. J Clin Psychiatry 56: 17-20.
140. Wisner KL, Perel JM, Findling RL (1996) Antidepressant treatment during breast-feeding. Am J Psychiatry 153: 1132-1137.
141. Wisner KL, Perel JM, Blumer J (1998) Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Am J Psychiatry 155: 690-692.
142. Wisner KL, Peindl KS, Gigliotti T, Hanusa BH (1999) Obsessions and compulsions in women with postpartum depression. J Clin Psychiatry 60: 176-180.
143. Wisner KL, Parry BL, Piontek CM (2002) Clinical practice. Postpartum depression. N Engl J Med 347: 194-199.
144. Wright S, Dawling S, Ashford JJ (1991) Excretion of fluvoxamine in breast milk. Br J Clin Pharmacol 31: 209.
145. Yaryura-Tobias JA, Neziroglu FA (1996) Venlafaxine in obsessive-compulsive disorder. Arch Gen Psychiatry 53: 653-654.
146. Yoshida K, Smith B, Craggs M, Kumar RC (1997a) Investigation of pharmacokinetics and of possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk. J Affect Disord 43: 225-237.
147. Yoshida K, Smith B, Kumar RC (1997b) Fluvoxamine in breast-milk and infant development. Br J Clin Pharmacol 44: 210-211.
148. Yoshida K, Smith B, Craggs M, Kumar RC (1998) Fluoxetine in breastmilk and developmental outcome of breast-fed infants. Br J Psychiatry 172: 175-178.
149. Zohar J, Judge R (1996) Paroxetine versus clomipramine in the treatment of obsessive-compulsive disorder. OCD Paroxetine Study Investigators. Br J Psychiatry 169: 468-474.