Paroxetine versus clomipramine in the treatment of Obsessive-Compulsive Disorder

British Journal of Psychiatry

Volumn 169, Issue 4, 1996, Pages 468-474

  Zohar, Joseph ^a,b   Judge, Rajinder ^c  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOMIPRAMINE; PAROXETINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPULSION; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSION; RANDOMIZED CONTROLLED TRIAL; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; CLOMIPRAMINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PAROXETINE; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 0029759206     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.169.4.468     Document Type: Article

References (26)

1. AMERICAN PSYCHIATRIC ASSOCIATION (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington, DC: APA.
2. ARMINEN, S. L., IKONEN, U., PULKKINEN, P., et al (1994) A 12-week double-blind multi-centre study of paroxetine and imipramine in hospitalized depressed patients. Acta Psychiatrica Scandinavica, 89, 382-389.
3. CHOUINARD, G., GOODMAN, W., GREIST, J., et al (1990) Results of a double-blind placebo-controlled trial of a new serotonin reuptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharmacology Bulletin, 26, 279-284.
4. DUNBAR, G. C., COHN, J. B., FABRE, L. F., et al (1991) A comparison of paroxetine, imipramine and placebo in depressed out-patients. British Journal of Psychiatry, 159, 394-398.
5. FINEBERG, N. A., BULLOCK, T., MONTGOMERY, D. B., et al (1992) Serotonin reuptake inhibitors are the treatment of choice in obsessive compulsive disorder. International Clinical Psychopharmacology, 7 (suppl. 1), 43-47.
6. FONTAINE, R. & CHOUINARD, G. (1985) Fluoxetine in the treatment of obsessive-compulsive disorder. Progress in Neuropsychopharmacology and Biological Psychiatry, 9, 605-608.
7. FREEMAN, C. P. L., TRIMBLE, M. R., DEAKIN, F. W., et al (1994) Fluvoxamine versus clomipramine in the treatment of obsessive compulsive disorder: a multicenter, randomised, double-blind, parallel group comparison. Journal of Clinical Psychiatry, 55, 301-305.
8. GOODMAN, W. K., PRICE, L. H. & RASMUSSEN, S. A., et al (1989) The Yale-Brown Obsessive Compulsive Scale. Archives of General Psychiatry, 46, 1006-1011 & 1012-1016.
9. _, MCDOUGLE, C. J. & PRICE, L. H. (1992) Pharmacotherapy of obsessive compulsive disorder. Journal of Clinical Psychiatry, 53 (suppl. 4), 29-37.
10. _, _, BARR, L. C., et al (1993) Biological approaches to treatment-resistant obsessive compulsive disorder. Journal of Clinical Psychiatry, 54 (suppl. 6), 16-26.
11. GREIST, J. H. (1992) An integrated approach to treatment of obsessive compulsive disorder. Journal of Clinical Psychiatry, 53 (suppl. 4), 38-41.
12. _, JEFFERSON, J. W., KOBAK, K. A., et al (1995a) Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Archives of General Psychiatry, 52, 53-60.
13. _, CHOUINARD, G., DUBOFF, E., et al (1995b) Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder. Archives of General Psychiatry, 52, 289-295.
14. JACKSON, C. W., MORTON, W. A. & LYDIARD, R. B. (1994) Pharmacologic management of obsessive-compulsive disorder. Southern Medical Journal, 87, 310-321.
15. MCTAVISH, D. & BENFIELD, P. (1990) Clomipramine: an overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs, 39, 136-153.
16. MONTGOMERY, S. A. & ÅSBERG, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382-389.
17. _, MCINTYRE, A., OSTERHEIDER, M., et al (1993) A double-blind placebo-controlled study of fluoxetine in patients with DSM-III-R obsessive-compulsive disorder. The Lilly European OCD Study Group. European Neuropsychopharmacology, 3, 143-152.
18. MURPHY, D. L., ZOHAR, J., BENKELFAT, C., et al (1989) Obsessive-compulsive disorder as a 5-HT subsystem-related behavioural disorder. British Journal of Psychiatry, 155 (suppl. 8), 15-24.
19. PARLOFF, M. B., KELMAN, H. C. & FRANK, J. D. (1954) Comfort, effectiveness and self-awareness as criteria of improvement in psychotherapy. American Journal of Psychiatry, 111, 343-351.
20. PIGOTT, T. A., PATO, M. T., BERNSTEIN, S. E., et al (1990) Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive-compulsive disorder. Archives of General Psychiatry, 47, 926-932.
21. RASMUSSEN, S. A. & EISEN, J. L. (1992) The epidemiology and clinical features of obsessive compulsive disorder. Psychiatric Clinics of North America, 15, 743-758.
22. SHEEHAN, D., DUNBAR, G. C. & FUELL, D. (1992) The effect of paroxetine on anxiety and agitation associated with depression. Psychopharmacology Bulletin, 2, 139-143.
23. STUPPAECK, C. H., GERETSEGGER, C., WHITWORTH, A. B., et al (1994) A multicenter double-blind trial of paroxetine versus amitriptyline in depressed inpatients. Journal of Clinical Psychopharmacology, 14, 241-246.
24. TOLLEFSON, G. D., RAMPEY, A.H. Jr., POTVIN, J. H., et al (1994) A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder. Archives of General Psychiatry, 51, 559-567.
25. TURNER, S. M., JACOB, R. G., BEIDEL, D. C., et al (1985) Fluoxetine treatment of obsessive-compulsive disorder. Journal of Clinical Psychopharmacology, 5, 207-212.
26. WEISSMAN, M. M., BLAND, R. C., CANINO, G. J., et al (1994) The cross national epidemiology of obsessive compulsive disorder. Journal of Clinical Psychiatry, 55 (suppl. 3), 5-10.