Apolipoprotein E and Alzheimer's disease;Apolipoproteína E e a doença de Alzheimer

Revista de Psiquiatria Clinica

Volumn 31, Issue 1, 2004, Pages 26-33

  Benquique Ojopi, Elida P ^a   Bruno Bertoncini, Alexandre ^a   Dias Neto, Emmanuel ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Alzheimer' disease; APOE; Apolipoprote na E

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL;

ALLELISM; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 19Q; CHROMOSOME ARM; DISEASE COURSE; DNA SEQUENCE; ENVIRONMENTAL FACTOR; GENE MAPPING; GENETIC CODE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; PROTEIN DEGRADATION; SEQUENCE ANALYSIS;

EID: 2342441697     PISSN: 01016083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. DE-ANDRADE, F.M.; LARRANDABURU, M.; CALLEGARI-JACQUES, S.M.; GASTALDO, G.; HUTZ, M.H. - Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population. Braz J Med Biol Res 33: 529-37, 2000.
2. ARTIGA, M.J.; BULLIDO, M.J.; FRANK, A.; SASTRE, I.; RECUERO, M.; GARCIA, M.A.; LENDON, C.L.; HAN, S.W.; MORRIS, J.C.; VAZQUEZ, J.; GOATE, A.; VALDIVIESO, F. - Risk for Alzheimer's disease correlates with transcriptional activity of the apoE gene. Hum Mol Genet 7: 1887-92, 1998.
3. BALES, K.R.; VERINA, T.; DODEL, R.C.; DU, Y.; ALTSTIEL, L., BENDER, M.; HYSLOP, P.; JOHNSTONE, E.M.; LITTLE, S.P.; CUMMINS, D.J.; PICCARDO P.; GHETTI B.; PAUL, S.M. - Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 17: 263-4, 1997.
4. BALES, K.R.; VERINA, T.; CUMMINS, D.J.; DU, Y.; DODEL, R.C.; SAURA, J.; FISHMAN, C.E.; DELONG, C.A.; PICCARDO, P., PETEGNIEF, V.; GHETTI, B.; PAUL, S.M. - Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 96: 15233-8, 1999.
5. BEYER, K.; LAO, J.I.; GOMEZ, M.; RIUTORT, N.; LATORRE, P.; MATE, J.L.; ARIZA, A. - Identification of a protective allele against Alzheimer disease in the apoE gene promoter. Neuroreport 13: 1403-5, 2002.
6. BOSCHERT, U.; MERLO-PICH, E.; HIGGINS, G.; ROSES, A.D.; CATSICAS, S. - Apolipoprotein E Expression by Neurons Surviving Excitotoxic Stress. Neurobiol Dis 6: 508-14, 1999.
7. BOYLES, J.K.; PITAS, R.E.; WILSON, E.; MAHLEY, R.W.; TAYLOR, J.M. - Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76: 1501-13, 1985.
8. CACABELOS, R. - Pharmacogenomics in Alzheimer's disease. Mini Rev Med Chem: 59-84, 2002.
9. CORBO, R.M.; SCACCHI, R. - Apolipoprotein E (apoE) allele distribution in the world: is apoE4 a 'thrifty' allele? Ann Hum Genet 63: 301-10, 1999.
10. CORDER, E.H.; LANNFELT, L.; BOGDANOVIC, N.; FRATIGLIONI, L.; MORI, H. - The role of apoE polymorphisms in late-onset dementias. Cell Mol Life Sci 54: 928-34, 1998.
11. CORDER, E.H.; SAUNDERS, A.M.; STRITTMATTER, W.J.; SCHMECHEL, D.E.; GASKELL, P.C.; SMALL, G.W.; ROSES, A.D.; HAINES, J.L.; PERICAK-VANCE, M.A. - Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-3, 1993.
12. CZYZEWSKI, K.; PFEFFER, A.; BARCIKOWSKA, M. - [Apolipoprotein E function in the nervous system]. Neurol Neurochir Pol 32: 125-32, 1998.
13. DAS, H.K.; MCPHERSON, J.; BRUNS, G.A. ET AL. - Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem 260: 6240-7, 1985.
14. ELSHOURBAGY, N.A.; LIAO, W.S.; MAHLEY, R.W. ET AL. - Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci USA 82: 203-7, 1985.
15. EWBANK, D.C. - A multistate model of the genetic risk of Alzheimer's disease. Exp Aging Res 28: 477-99, 2002.
16. FULLERTON, S.M.; CLARK, A.G.; WEISS, K.M. ET AL. - Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet 67: 881-900, 2000.
17. GOLDSTEIN, F.C.; ASHLEY, A.V.; GEARING, M.; HANFELT, J.; PENIX, L.; FREEDMAN L.J.; LEVEY, A.I. - Apolipoprotein E and age at onset of Alzheimer's disease in African American patients. Neurology 57: 1923-5, 2001.
18. KIM, J.M.; SHIN, I.S.; YOON, J.S. - Apolipoprotein E among Korean Alzheimer's disease patients in community-dwelling and hospitalized elderly samples. Dement Geriatr Cogn Disord 13: 119-24, 2002.
19. LAWS, S.M.; HONE, E.; GANDY, S. ET AL. - Expanding the association between the apoE gene and the risk of Alzheimer's disease: possible roles for apoE promoter polymorphisms and alterations in apoE transcription. J Neurochem 84: 1215-36, 2003.
20. LIN, C.T.; XU, Y.F.; WU, J.Y. ET AL. - Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues. J Clin Invest 78: 947-58, 1986.
21. MARTINS, R.N.; CLARNETTE, R.; FISHER, C. ET AL. - ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. Neuroreport 6: 1513-6, 1995.
22. MENSENKAMP, A.R.; JONG, M.C.; VAN GOOR, H.; VAN LUYN, M.J.; BLOKS, V.; HAVINGA, R.; VOSHOL, P.J.; HOFKER, M.H.; VAN DUK, K.W.; HAVEKES, L.M.; KUIPERS, F. - Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. J Biol Chem 274: 35711-8, 1999.
23. NAKAI, M.; KAWAMATA, T.; TANIGUCHI, T.; MAEDA, K.; TANAKA, C. - Expression of apolipoprotein E mRNA in rat microglia. Neurosci Lett 211: 41-4, 1996.
24. NICKERSON, D.A.; TAYLOR, S.L.; FULLERTON, S.M. ET AL. - Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. Genome Res 10: 1532-45, 2000.
25. OLAISEN, B.; TEISBERG, P.; GEDDE-DAHL, T. JR. - The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man. Hum Genet 62: 233-6, 1982.
26. PAIK, Y.K.; CHANG, D.J.; REARDON, C.A.; DAVIES, G.E.; MAHLEY, R.W.; TAYLOR, J.M. - Nucleotide sequence and structure of the human apolipoprotein E gene. Proc Natl Acad Sci USA 82: 3445-9, 1985.
27. PANZA, F.; SOLFRIZZI, V.; D'INTRONO, A.; CAPURSO, C.; COLACICCO, A.M.; TORRES, F.; ALTOMARE, E.; CAPURSO, A. - Genetics of late-onset Alzheimer's disease: vascular risk and beta-amyloid metabolism Recenti Prog Med 9: 489-97, 2002.
28. PITAS, R.E.; BOYLES, J.K.; LEE, S.H.; FOSS, D.; MAHLEY, R.W. - Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E- containing lipoproteins. Biochim Biophys Acta 917: 148-61, 1987.
29. PUGLIELLI, L.; TANZI, R.E.; KOVACS, D.M. - Alzheimer's disease: the cholesterol connection. Nat Neurosci 6: 345-51, 2003.
30. RALL, S.C. JR.; WEISGRABER, K.H.; INNERARITY, T.L.; ET AL. - Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proc Natl Acad Sci USA 79: 4696-700, 1982a.
31. RALL, S.C. JR.; WEISGRABER, K.H.; MAHLEY, R.W.; ET AL. - Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 257: 4171-8, 1982b.
32. ROCCHI, A.; PELLEGRINI, S.; SICILIANO, G.; MURRI, L. - Causative and susceptibility genes for Alzheimer's disease: a review. Brain Research Bulletin 61: 1-24, 2003.
33. ROKS, G.; CRUTS, M.; BULLIDO, M.J.; BACKHOVENS, H.; ARTIGA, M.J.; HOFMAN, A.; VALDIVIESO, F.; VAN BROECKHOVEN, C.; VAN DUUN, C.M. - The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease. Neurosci Lett 258: 65-8, 1998.
34. ROSES, A.D.; GILBERT, J.; XU, P.T.; SULLIVAN, P.; POPKO, B.; BURKHART, D.S.; CHRISTIAN-ROTHROCK, T.; SAUNDERS, A.M.; MAEDA, N.; SCHMECHEL, D.E. - Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. Neurobiol Aging 19: S53-8, 1998.
35. SAUNDERS, A.M.; SCHMADER, K.; BREITNER, J.C.S.; BENSON, M.D.; BROWN, W.T.; GOLDFARB, L.; GOLDGABER, D.; MANWARING, M.G.; SZYMANSKI, M.H.; MCCOWN, N. ; DOLE, K.C.; SCHMECHEL, D.E.; STRITTMATTER, W.J.; PERICAK-VANCE, M.A.; ROSES, A.D. - Apolipoprotein E epsilon-4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 342: 710-1, 1993.
36. SCARMEAS, N.; BRANDT, J.; ALBERT, M.; DEVANAND, D.P.; MARDER, K.; BELL, K.; CIAPPA, A.; TYCKO, B.; STERN, Y. - Association between the apoE genotype and psychopathologic symptoms in Alzheimer's disease. Neurology 58: 1182-8, 2002.
37. SOUZA, D.R.; DE GODOY, M.R.; HOTTA, J.; TAJARA, E.H.; BRANDÃO, A.C.; PINHEIRO JUNIOR, S.; TOGNOLA, W.A.; DOS SANTOS, J.E. - Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Braz J Med Biol Res 36: 919-23, 2003.
38. TANZI, R.E.; BERTRAM, L. - New frontiers in Alzheimer's disease genetics. Neuron 32: 181-4, 2001.
39. UTERMANN, G.; PRUIN, N.; STEINMETZ, A. - Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man. Clin. Genet. 15: 63-72, 1979.
40. UTERMANN, G.; LANGENBECK, U.; BEISIEGEL, U.; ET AL. - Genetics of the apolipoprotein E system in man. Am J Hum Genet 32: 339-47, 1980.
41. WEISGRABER, K.H.; INNERARITY, T.L.; MAHLEY, R.W. - Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem 257: 2518-21, 1982.
42. WEISGRABER, K.H.; RALL, S.C., JR.; MAHLEY, R.W. - Human E apoprotein hete-rogeneity: cysteine-arginine interchanges in the amino-acid sequence of the apo-E isoforms. J Biol Chem 256: 9077-83, 1981.
43. XU, P.T.; GILBERT, J.R; QIU, H.L.; ERVIN, J.; ROTHROCK-CHRISTIAN, T.R.; HULETTE, C.; SCHMECHEL, D.E. - Specific regional transcription of apolipoprotein E in human brain neurons. Am J Pathol 154: 601-11, 1999.
44. YIP, A.G.; BRAYNE, C.; EASTON, D.; RUBINSZTEIN, D.C. - Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. J Med Genet 39: 639-43, 2002.
45. YOSHIZAWA, T.; YAMAKAWA-KOBAYASHI, K.; KOMATSUZAKI, Y.; ARINAMI, T.; OGUNI, E.; MIZUSAWA, H.; SHOJI, S.; HAMAGUCHI, H. - Dose-dependent association of apolipoprotein E allele epsilon-4 with late-onset, sporadic Alzheimer's disease. Ann Neurol 36: 656-9, 1994.