Impact of highly active antiretroviral therapy on the spectrum of liver disease in hcv-hiv coinfection

Clinical Gastroenterology and Hepatology

Volumn 2, Issue 5, 2004, Pages 432-439

  Sterling, Richard K ^a,b   Wilson, Mary S ^a   Sanyal, Arun J ^a   Luketic, Velimir A ^a   Stravitz, R Todd ^a   Contos, Melissa J ^a   Mills, A Scott ^a   Shiffman, Mitchell L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

alanine aminotransferase; ALT; anti HIV; antibody to human immunodeficiency virus; HAART; HAI; HCV; hepatitis C virus; highly active antiretroviral therapy; Histological Activity Index; HIV; human immunodeficiency virus; NNRTI; PI; protease inhibitor

Indexed keywords

ALANINE AMINOTRANSFERASE; AMPRENAVIR; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; EFAVIRENZ; INDINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR;

AFRICAN AMERICAN; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FIBROSIS; GENOTYPE; HEPATITIS; HEPATITIS C VIRUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LIVER DISEASE; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; POPULATION; VIRUS HEPATITIS;

ADULT; ALANINE TRANSAMINASE; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; FEMALE; HEPACIVIRUS; HEPATITIS C; HIV INFECTIONS; HUMANS; LIVER; MALE; MIDDLE AGED; PROTEASE INHIBITORS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL;

EID: 2342441253     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1542-3565(04)00129-6     Document Type: Article

References (52)

1. Spengler U., Rockstroh J.K. Hepatitis C in the patient with human immunodeficiency virus infection. J Hepatol. 29:1998;1023-1030
2. Dieterich D.T. Hepatitis C virus and human immunodeficiency virus clinical issues in coinfection. Am J Med. 107:(suppl 6B):1999;S79-S84
3. Sulkowski M.S., Brinkley-Laughton S., Thomas D.L. HCV and HIV co-infection prevalence, genotype distribution and severity of liver disease in an urban HIV clinic. Hepatology. 32:2000;212A. [abstract 204]
4. Sherman K.E., Rouster S.D., Chung R.T., Rajicic N. Hepatitis C virus prevalence among patients infected with human immunodeficiency virus a cross-sectional analysis of the US Adult AIDS Clinical Trials Group. Clin Infect Dis. 34:2002;831-837
5. Palella F.J. Jr, Delaney K.M., Moorman A.C., Loveless M.O., Fuhrer J., Satten G.A., Ashman D.J., Holmberg S.D. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 338:1998;853-860
6. Lee L.M., Karon J.M., Selik R., Neal J.J., Fleming P.L. Survival after AIDS diagnosis in adolescents and adults during the treatment era, United States, 1984-1997. JAMA. 285:2001;1308-1315
7. Poles M.A., Dieterich D.T. Hepatitis C virus/human immunodeficiency virus coinfection clinical management issues. Clin Infect Dis. 31:2000;154-161
8. Greub G., Ledergerber B., Battegay M., Grob P., Perrin L., Furrer H., Burgisser P., Erb P., Boggian K., Piffaretti J.C., Hirschel B., Janin P., Framcioli P., Flepp M., Telenti A. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection the Swiss HIV Cohort Study. Lancet. 356:2000;1800-1805
9. Darby S.C., Ewart D.W., Giangrande P.L., Spooner R.J., Rizza C.R., Dusheiko G.M., Lee C.A., Ludlam C.A., Preston F.E. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. UK Haemophilia Centre Directors' Organisation. Lancet. 350:1997;1425-1431
10. Bica I., McGovern B., Dhar R., Stone D., McGowan K., Scheib R., et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis. 32:2001;492-497
11. Monga H.K., Rodriguez-Barradas M.C., Breaux K., Khattak K., Troisi C.L., Velez M., Yoffe B. Hepatitis C virus infection-related morbidity and mortality among patients with human immunodeficiency virus infection. Clin Infect Dis. 33:2001;240-247
12. Ragni M.V., Belle S.H. Impact of human immunodeficiency virus infection on progression to end-stage liver disease in individuals with hemophilia and hepatitis C virus infection. J Infect Dis. 183:2001;1112-1115
13. Graham C.S., Baden L.R., Yu E., Mrus J.M., Carnie J., Heeren T., Koziel M.J. Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection a meta-analysis. Clin Infect Dis. 33:2001;562-569
14. Yeni P.G., Hammer S.M., Carpenter C.C., Cooper D.A., Fischl M.A., Gatell J.M., Gazzard B.G., Hirsch M.S., Jacobsen D.M., Katzenstein P.A., Montaner J.S., Richman D.D., Saag M.S., Schechter M., Schooley R.T., Thompson M.A., Vella S., Volberding P.A. Antiretroviral treatment for adult HIV infection in 2002 updated recommendations of the International AIDS Society-USA Panel. JAMA. 288:2002;222-235
15. Spengler U., Lichterfeld M., Rockstroh J.K. Antiretroviral drug toxicity - a challenge for the hepatologist? J Hepatol. 36:2002;283-294
16. den Brinker M., Wit F.W., Wertheim-van Dillen P.M., Jurriaans S., Weel J., van Leeuwen R., Pakker N.G., Reiss P., Danner S.A., Waverling G.T., Lange J.M. Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection. AIDS. 14:2000;2895-2902
17. Gavazzi G., Bouchard O., Leclercq P., Morel-Baccard C., Bosseray A., Dutertre N., Micoud M., Morand P. Change in transaminases in hepatitis C v. AIDS. Res Hum Retroviruses. 16:2000;1021-1023
18. Sulkowski M.S., Thomas D.L., Chaisson R.E., Moore R.D. Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA. 283:2000;74-80
19. Monforte A.A., Bugarini R., Pezzotti P., De Luca A., Antinori A., Mussini C., Vigevani G.M., Tirelli V., Bruno R., Gritti F., Piazza M., Chigiotti S., Chirianni A., De Stefano C., Pizzigallo E., Perrella O., Morori M. Low frequency of severe hepatotoxicity and association with HCV coinfection in HIV-positive patients treated with HAART. J Acquir Immune Defic Syndr. 28:2001;114-123
20. Cooper C.L., Parbhakar M.A., Angel J.B. Hepatotoxicity associated with antiretroviral therapy containing dual versus single protease inhibitors in individuals coinfected with hepatitis C virus and human immunodeficiency virus. Clin Infect Dis. 34:2002;1259-1263
21. John M., Flexman J., French M.A. Hepatitis C virus-associated hepatitis following treatment of HIV-infected patients with HIV protease inhibitors an immune restoration disease? AIDS. 12:1998;2289-2293
22. Stone S.F., Lee S., Keane N.M., Price P., French M.A. Association of increased hepatitis C virus (HCV)-specific IgG and soluble CD26 dipeptidyl peptidase IV enzyme activity with hepatotoxicity after highly active antiretroviral therapy in human immunodeficiency virus-HCV-coinfected patients. J Infect Dis. 186:2002;1498-1502
23. Rutschmann O.T., Negro F., Hirschel B., Hadengue A., Anwar D., Perrin L.H. Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV. J Infect Dis. 177:1998;783-785
24. Zylberberg H., Chaix M.L., Rabian C., Rouzioux C., Aulong B., Brechot C., Viard J.P., Pol S. Tritherapy for human immunodeficiency virus infection does not modify replication of hepatitis C virus in coinfected subjects. Clin Infect Dis. 26:1998;1104-1106
25. Puoti M., Gargiulo F., Roldan E.Q., Chiodera A., Palvarini L., Spinetti A., Zaltran S., Putzolu V., Zanini B., Favilli F., Turano A., Carosi G. Liver damage and kinetics of hepatitis C virus and human immunodeficiency virus replication during the early phases of combination antiretroviral treatment. J Infect Dis. 181:2000;2033-2036
26. Ragni M.V., Bontempo F.A. Increase in hepatitis C virus load in hemophiliacs during treatment with highly active antiretroviral therapy. J Infect Dis. 180:1999;2027-2029
27. Garcia-Samaniego J., Bravo R., Castilla J., Gomez-Cano M., Laguna F., Munoz F., Sariano V. Lack of benefit of protease inhibitors on HCV viremia in HIV-infected patients. J Hepatol. 28:1998;526-527
28. Yokozaki S., Takamatsu J., Nakano I., Katano Y., Toyoda H., Hayashi K., Hayakawa T., Fukuda Y. Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus influence of antiretroviral therapy. Blood. 96:2000;4293-4299
29. Cooper C.L., Cameron D.W. Review of the effect of highly active antiretroviral therapy on hepatitis C virus (HCV) RNA levels in human immunodeficiency virus and HCV coinfection. Clin Infect Dis. 35:2002;873-879
30. Chung R.T., Evans S.R., Yang Y., Theodore D., Valdez H., Clark R., Shikuma C., Nevin T., Sherman K.E. Immune recovery is associated with persistent rise in hepatitis C virus RNA, infrequent liver test flares, and is not impaired by hepatitis C virus in co-infected subjects. AIDS. 16:2002;1915-1923
31. Torre D., Tambini R., Cadario F., Barbarini G., Moroni M., Basilico C. Evolution of coinfection with human immunodeficiency virus and hepatitis C virus in patients treated with highly active antiretroviral therapy. Clin Infect Dis. 33:2001;1579-1585
32. Guido M., Rugge M., Fattovich G., Rocchetto P., Cassaro M., Chemello L., Noventa F., Giustina G., Alberti A. Human immunodeficiency virus infection and hepatitis C pathology. Liver. 14:1994;314-319
33. Bierhoff E., Fischer H.P., Willsch E., Rockstroh J., Spengler U., Brackmann H.H., Oldenburg J. Liver histopathology in patients with concurrent chronic hepatitis C and HIV infection. Virchows Arch. 430:1997;271-277
34. Puoti M., Bonacini M., Spinetti A., Putzolu V., Govindarajan S., Zaltron S., Favret M., Callea F., Gargiulo F., Danato F., Carosi G. Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus. J Infect Dis. 183:2001;134-137
35. Garcia-Samaniego J., Soriano V., Castilla J., Bravo R., Moreno A., Carbo J., Iniguez A., Gonzalez J., Munoz F. Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The Hepatitis/HIV Spanish Study Group. Am J Gastroenterol. 92:1997;1130-1134
36. Allory Y., Charlotte F., Benhamou Y., Opolon P., Le Charpentier Y., Poynard T. The MULTIVIRC group. Impact of human immunodeficiency virus infection on the histological features of chronic hepatitis C a case-control study. Hum Pathol. 31:2000;69-74
37. Benhamou Y., Bochet M., Di M.V., Charlotte F., Azria F., Coutellier A., Vidaud M., Bricaire F., Opolan P., Katlama C., Poynard T. Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatology. 30:1999;1054-1058
38. Sterling R.K., Contos M.J., Sanyal A.J., Luketic V.A., Stravitz R.T., Wilson M.S., Mills A.S., Shiffman M.L. The clinical spectrum of hepatitis C virus in HIV coinfection. J Acquir Immune Defic Syndr. 32:2003;30-37
39. Benhamou Y., Di M.V., Bochet M., Colombet G., Thibault V., Liou A., Katlama C., Poynard T. Factors affecting liver fibrosis in human immunodeficiency virus- and hepatitis C virus-coinfected patients impact of protease inhibitor therapy. Hepatology. 34:2001;283-287
40. Knodell R.G., Ishak K.G., Black W.C., Chen T.S., Craig R., Kaplowitz N., Kiernan T.W., Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1:1981;431-435
41. Sterling R.K., Sanyal A.J., Luketic V.A., Stravitz R.T., King A.L., Post A.B., Mills A.S., Contos M.J., Shiffman M.L. Chronic hepatitis C infection in patients with end stage renal disease characterization of liver histology and viral load in patients awaiting renal transplantation. Am J Gastroenterol. 94:1999;3576-3582
42. Shiffman M.L., Stewart C.A., Hofmann C.M., Contos M.J., Luketic V.A., Sterling R.K., Sanyal A.J. Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels comparison of hepatic histology and response to interferon therapy. J Infect Dis. 182:2000;1595-1601
43. Martinot-Peignoux M., Boyer N., Cazals-Hatem D., Pham B.N., Gervais A., Le B.V., Levy S., Degott C., Valla D.C., Marcellin P. Prospective study on anti-hepatitis C virus-positive patients with persistently normal serum alanine transaminase with or without detectable serum hepatitis C virus RNA. Hepatology. 34:2001;1000-1005
44. Ghany M.G., Leissinger C., Lagier R., Sanchez-Pescador R., Lok A.S. Effect of human immunodeficiency virus infection on hepatitis C virus infection in hemophiliacs. Dig Dis Sci. 41:1996;1265-1272
45. Lebovics E., Thung S.N., Schaffner F., Radensky P.W. The liver in the acquired immunodeficiency syndrome a clinical and histologic study. Hepatology. 5:1985;293-298
46. Gordon S.C., Reddy K.R., Gould E.E., McFadden R., O'Brien C., De Medina M., Jeffers L.J., Schiff E.R. The spectrum of liver disease in the acquired immunodeficiency syndrome. J Hepatol. 2:1986;475-484
47. Schneiderman D.J., Arenson D.M., Cello J.P., Margaretten W., Weber T.E. Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS). Hepatology. 7:1987;925-930
48. Grumbach K., Coleman B.G., Gal A.A., Arger P.H., Mintz M.C., Arenson R.L., Aquino L. Hepatic and biliary tract abnormalities in patients with AIDS. Sonographic-pathologic correlation. J Ultrasound Med. 8:1989;247-254
49. Cappell M.S., Schwartz M.S., Biempica L. Clinical utility of liver biopsy in patients with serum antibodies to the human immunodeficiency virus. Am J Med. 88:1990;123-130
50. Wilkins M.J., Lindley R., Dourakis S.P., Goldin R.D. Surgical pathology of the liver in HIV infection. Histopathology. 18:1991;459-464
51. Bach N., Theise N.D., Schaffner F. Hepatic histopathology in the acquired immunodeficiency syndrome. Semin Liver Dis. 12:1992;205-212
52. Poles M.A., Dieterich D.T., Schwarz E.D., Weinshel E.H., Lew E.A., Lew R., Scholes J.V. Liver biopsy findings in 501 patients infected with human immunodeficiency virus (HIV). J Acquir Immune Defic Syndr Hum Retrovirol. 11:1996;170-177