Increase in hepatitis C virus load in hemophiliacs during treatment with highly active antiretroviral therapy

Journal of Infectious Diseases

Volumn 180, Issue 6, 1999, Pages 2027-2029

  Ragni, Margaret V ^a,b,c,d   Bontempo, Franklin A ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Hemophilia Center of Western Pennsylvania   (United States)

^c INSTITUTE FOR TRANSFUSION MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; NELFINAVIR; STAVUDINE; VIRUS RNA; ZIDOVUDINE;

ARTICLE; CLINICAL ARTICLE; HELPER CELL; HEMOPHILIA; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; LIVER FUNCTION; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; VIRUS LOAD;

ANTI-HIV AGENTS; DRUG THERAPY, COMBINATION; HEMOPHILIA A; HEPACIVIRUS; HEPATITIS C; HIV; HIV INFECTIONS; HUMANS; MALE; POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL LOAD; VIREMIA;

EID: 0032728393     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315143     Document Type: Article

References (17)

1. 1. Seeff LB. Natural history of hepatitis C. Hepatology 1997;26(Suppl 1): 21S-8S.
2. 2. Ragni MV, Ndimbie OK, Rice EO, Bontempo FA, Nedjar S. The presence of hepatitis C virus (HCV) antibody in human immunodeficiency virus positive hemophilic men undergoing HCV "seroreversion." Blood 1993;82:1010-5.
3. 3. Hay CRM, Preston FE, Triger DR, Underwood JCE. Progressive liver disease in hemophilia: an understated problem? Lancet 1985;1:495-8.
4. 4. Ragni MV, Belle SH, Jaffe RA, et al. Acquired immunodeficiency syndrome-associated non-Hodgkin's lymphomas and other malignancies in patients with hemophilia. Blood 1993;81:1889-97.
5. 5. Ewenstein B, Koerper M. Survey of diagnostic and treatment practices of chronic hepatitis C in federally funded hemophilia treatment centers. Presented at the Medical and Scientific Advisory Council meeting (Orlando, FL). October 1998.
6. 6. Eyster ME, Fried MW, DiBisceglie AM, Goedert JJ. Increasing hepatitis C RNA levels in hemophiliacs: relationship to human immunodeficiency infection and liver disease. Blood 1994;84:1020-3.
7. 7. Darby SC, Ewart DW, Giangrande PLF, et al. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. UK Haemophilia Centre Directors' Organisation. Lancet 1997;350:1425-31.
8. 8. Fauci AS, Pantaleo G, Stanley S, Weissman D. Immunopathogenic mechanisms of HIV infection. Ann Intern Med 1996;124:654-63.
9. 9. Jarvis LM, Watson HG, McOmish F, Peutherer JF, Ludlam CA, Simmonds P. Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused hemophiliacs. J Infect Dis 1994;170:1018-22.
10. 10. Rockstroh JK, Spengler U, Sudhop T, et al. Immunosuppression may lead to progression of hepatitis C virus-associated liver disease in hemophiliacs coinfected with HIV. Am J Gastroenterol 1996;91:2563-8.
11. 11. Urdea MS. Synthesis and characterization of branched-chain DNA (bDNA) for the direct and quantitative detection of CMV, HBV, HCV, and HIV. Clin Chem 1993;39:725-6.
12. 12. Rockstroh JK, Theisen A, Kaiser R, et al. Antiviral combination therapy decreases HIV load but does not alter hepatitis C virus (HCV) replication [abstract 735]. Hepatology 1997;26:312a.
13. 13. Seto Y, Higasa S, Ueda M, et al. Effect of protease inhibitors on liver function in hemophiliacs with HIV-HCV coinfection [abstract 736]. Hepatology 1997;26:312a.
14. 14. Erhardt A, Mauss S, Adams O, et al. HIV protease inhibitors do not reduce hepatitis C virus 7(HCV) replication in patients with HIV and HCV [abstract 737]. Hepatology 1997;26:312a.
15. 15. Rutschmann OT, Negro F, Hirschel B, et al. Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV. J Infect Dis 1998;177:783-5.
16. 16. Zylergerg H, Chaix ML, Rabian C, et al. Tritherapy for human immunodeficiency virus infection does not modify replication of hepatitis C virus in coinfected subjects. Clin Infect Dis 1998;26:1104-6.
17. 17. Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biempica L. In vitro and in vivo association of transforming growth factor-β1 with hepatic fibrosis. J Cell Biol 1989;108:2477-82.