Development of new reverse micellar microencapsulation technique to load water-soluble drug into PLGA microspheres

Archives of Pharmacal Research

Volumn 28, Issue 3, 2005, Pages 370-375

  Kim, Hyunjoo ^a   Cho, Mihyun ^a   Sah, Hongkee ^a  

^a Catholic University of Daegu   (South Korea)

Author keywords

Microencapsulation; Microspheres; PLGA; Reverse micelles

Indexed keywords

DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER; TETRACYCLINE; WATER;

ARTICLE; CHEMISTRY; MICELLE; MICROCAPSULE; PHARMACEUTICS; SOLUBILITY;

CAPSULES; DRUG CARRIERS; LACTIC ACID; MICELLES; POLYGLYCOLIC ACID; POLYMERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TETRACYCLINE; WATER;

EID: 23344449515     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977807     Document Type: Article

References (20)

1. Al-Maaieh, A. and Flanagan, D. R., Salt and cosolvent effects on ionic drug loading into microspheres using an O/W method. J. Control Release, 70, 169-181 (2001).
2. Bausch, T. E., Plucinski, P. K., and Nitsch, W., Kinetics of reextraction of hydrophilic solutes out of AOT-reversed micelles. J. Colloid Interface Sci., 150, 226-234 (1992).
3. Benoit, J.-P., Marchais, H., Rolland, H., and Velde, V. V., Biodegradable microsphers: advances in production technology, In Benita, S. (Ed). Microencapsulation: Methods and Industrial Applications. Marcel Dekker, New York, pp. 35-72 (1996).
4. Chen, J. L., Chiang, C. H., and Yeh, M. K., The mechanism of PLA microparticle formation by water-in-oil-in-water solvent evaporation method. J. Microencapsulation, 19, 333-346 (2002).
5. Esposito, E., Cortesi, R., Certvellati, F., Menegatti, E., and Nastruzzi, C., Biodegradable microparticles for sustained delivery of tetracycline to the periodontal pocket: formulatory and drug release studies. J. Microencapsulation, 14, 175-187 (1997).
6. Farrar, G. H., Tinsley-Brown, A. M., and Jones, D. H., Encapsulation of bioactive agents. US patent 6,406,719 (2002)
7. Freytag, T., Dashevsky, A., Tillman, L., Hardee, G. E., and Bodmeier, R., Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres. J. Control Release, 69, 197-207 (2000).
8. Hamont, J. V., Thies, C., Reid, R. H., McQueen, C. E., and Setterstrom, J. A., Extraction process for producing PLGA microspheres. US Patent 5,705,197 (1998).
9. Hayashi, Y., Yoshioka, S., Aso, Y., Po, A. L. W., and Terao, T., Entrapment of proteins in poly(l-lactide) microspheres using reversed micelle solvent evaporation. Pharm. Res., 11, 337-340 (1994).
10. Jarudilokkul, S., Paulsen, E., and Stuckey, D. C., Lysozyme extraction from egg white using reverse micelles in a graesser contactor: mass transfer characterization. Biotech. Bioeng., 69, 618-626 (2000).
11. Jiang, G., Thanoo, B. C., and DeLuca, P. P., Effect of osmotic pressure on the solvent extraction phase on BSA release profile from PLGA microspheres. Pharm. Dev. Technol., 7, 391-399 (2002).
12. Joly, V., Encian, G. G., Cohen, M. S., and Thies, C., Effect of salts on formation of lactide-glycolide microparticles in aqueous media. Proceedings of the International Symposium on Controlled Release of Bioactive Materials, 21, 282-283 (1994).
13. Lee, J. H., Park, T. G., and Choi, H. K., Effect of formulation and processing variables on the characteristics of microspheres for water-soluble drugs prepared by w/o/w double emulsion solvent diffusion method. Int. J. Pharm., 196, 75-83 (2000).
14. Lesser, M. E., Wei, G., Luisi, P. L., and Maestro, M., Application of reverse micelles for the extraction of protains. Biochem. Biophys. Res. Commun., 135, 629-635 (1986).
15. Mandal, T. K., Effect of solvent on the characteristics of pentamidine loaded microcapsule. J. Biomater. Sci. Polymer Edn., 10, 1-17 (1999).
16. McGinity, J. W. and Iwata, M., Preparation and uses of multiphase microspheres. US patent 5,288,502 (1994).
17. Ogawa, Y., Yammamoto, M., Okada, H., Yashiki, T., and Shimamoto, T., Technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly (lactide/glycolic acid). Chem. Pharm. Bull., 36, 1095-2030 (1988).
18. Pires, M. J., Aaires-Barros, M. R., and Cabral, J. M. S., Liquid-liquid extraction of a recombinant protein with reverse micelles. Biotechnol. Prog., 12, 290-301 (1996).
19. Sah, H., Ethyl formate - alternative dispersed solvent useful in preparing PLGA microspheres. Int. J. Pharm., 195, 103-113 (2000).
20. Scholes, P. D., Coombes, A. G. A., Davies, M. C., Illum, L., and Davis, S. S., Particle engineering of biodegradable colloids for site-specific drug delivery, In Park, K. (Ed). Controlled Drug Delivery, Challenges and Strategies. American Chemical Society, Washington DC, pp. 73-106 (1997).