DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21 WAF1/Cip1

International Journal of Cancer

Volumn 116, Issue 4, 2005, Pages 506-513

  Clark, Martin A ^a   Perks, Claire M ^a   Winters, Zoë E ^a,b   Holly, Jeff M P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

IGF I; MCF 7 breast epithelial cells; p21WAF1 Cip1; PI3K

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1; DNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; SOMATOMEDIN C;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER GROWTH; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GAMMA IRRADIATION; GROWTH DISORDER; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ULTRAVIOLET RADIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MITOGENS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 23244450269     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21029     Document Type: Article

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