p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

Cellular Signalling

Volumn 15, Issue 1, 2003, Pages 95-102

  Latonen, Leena ^a   Kurki, Sari ^a   Pitkänen, Kimmo ^a   Laiho, Marikki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

MDM2; p53; PI 3 kinases; Ubiquitin proteasome pathway; UV radiation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CHROMONE DERIVATIVE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ENZYME INHIBITOR; LEUPEPTIN; MDM2 PROTEIN, HUMAN; MDM2 PROTEIN, MOUSE; MORPHOLINE DERIVATIVE; MULTIENZYME COMPLEX; NUCLEAR PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN MDM2; PROTEIN P53;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; COMPARATIVE STUDY; DNA DAMAGE; DRUG ANTAGONISM; HUMAN; METABOLISM; MOUSE; NUCLEOLUS; PHYSIOLOGY; TRANSACTIVATION; ULTRAVIOLET RADIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; STRESS; ULTRAVIOLET IRRADIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; CELL NUCLEOLUS; CELLS, CULTURED; CHROMONES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA DAMAGE; ENZYME INHIBITORS; HUMANS; LEUPEPTINS; MICE; MORPHOLINES; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0037209627     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(02)00044-X     Document Type: Article

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