Identification of skin injury-related genes induced by ionizing radiation in human keratinocytes using cDNA microarray

Journal of Radiation Research

Volumn 46, Issue 2, 2005, Pages 173-184

  Koike, Manabu ^a   Shiomi, Tomoe ^a   Koike, Aki ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Apoptosis; ATF3; Keratinocyte; Skin; X ray

Indexed keywords

AIRCRAFT ENGINE MANUFACTURE; ELECTROPHORESIS; GENES; IONIZING RADIATION; IRRADIATION; RADIATION SHIELDING;

ATF3; EXPOSED TO; HIGH DOSE; HUMAN KERATINOCYTE; KERATINOCYTES; MOLECULAR LEVELS; RADIATION EXPOSURE; RADIATION INJURY; SKIN CANCERS; SKIN INJURIES;

CELL DEATH;

ANIMAL; ARTICLE; CELL CULTURE; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; INJURY; IONIZING RADIATION; KERATINOCYTE; METABOLISM; METHODOLOGY; MOUSE; RADIATION DERMATITIS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SKIN;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIATION DOSAGE; RADIATION, IONIZING; RADIODERMATITIS; SKIN;

EID: 23244443818     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.46.173     Document Type: Article

References (35)

1. Parkinson, E. K., Hume, W. J.,and Potten, C. S. (1986) The radiosensitivity of cultured human and mouse keratinocytes. Int. J. Radiat. Biol. 50: 717-726.
2. Dent, P., Yacoub, A., Fisher, P. B., Hagan, M. P., and Grant, S. (2003) MAPK pathways in radiation responses. Oncogene 22: 5885-5896.
3. Amundson, S. A., Bittner, M., Chen, Y., Trent, J., Meltzer, P., and Fornace Jr., A. J. (1999) Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18: 3666-3672.
4. Park, W. Y., Hwang, C. I., Im, C. N., Kang, M. J., Woo, J. H., Kim, J. H., Kim, Y. S., Kim, H. Kim, J. H., Kim, K. A., Yu, H. J., Lee, S. J., Lee, Y. S., and Seo, J. S. (2002) Identification of radiation-specific responses from gene expression profile. Oncogene 21: 8521-8528.
5. Koike, M., Kuroiwa, A., Koike, A., Shiomi, T., and Matsuda, Y. (2001) Expression and chromosome location of hamster Ku70 and Ku80. Cytogenet. Cell. Genet. 93: 52-56.
6. Koike, M., and Koike, A. (2004) Establishment and characterization of stable cell Lines expressing human Ku80 tagged with enhanced green fluorescent protein. J. Radiat. Res. 45: 119-125.
7. Wang, J. A., Fan, S., Yuan, R. Q., Ma, Y. X., Meng, Q., Goldberg, I. D., and Rosen, E. M. (1999) Ultraviolet radiation down-regulates expression of the cell-cycle inhibitor p21WAF1/CIP1 in human cancer cells independently of p53. Int. J. Radiat. Biol. 75: 301-316.
8. Bailey, J., Phillips, R. J., Pollard, A. J., Gilmore, K., Robson, S. C., and Europe-Finner, G. N. (2002) Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: Identification of a novel ATF2 species with potent transactivation properties. J. Clin. Endocrinol. Metab. 87: 1717-1728.
9. Abe, T., Oue, N., Yasui, W., and Ryoji, M. (2003) Rapid and preferential induction of ATF3 transcription in response to low doses of UVA light. Biochem. Biophys. Res. Commun. 310: 1168-1174.
10. Hashimoto, Y., Zhang, C., Kawauchi, J., Imoto, I., Adachi, M. T., Inazawa, J., Amagasa, T., Hai, T., and Kitajima, S. (2002) An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic. Acids Res. 30: 2398-2406.
11. Koike, M., Ikuta, T., Miyasaka, T., and Shiomi, T. (1999) Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal. Oncogene 18: 7495-7505.
12. Koike, M., Shiomi, T., and Koike, A. (2001) Dimerization and nuclear localization of Ku proteins. J. Biol. Chem. 276: 11167-11173.
13. Koike, M., Ikuta, T., Miyasaka, T., and Shiomi, T. (1999) The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex. Exp. Cell Res. 250: 401-413.
14. Mo, X., and Dynan, W. S. (2002) Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites. Mol. Cell. Biol. 22: 8088-8099.
15. Hai, T., Wolfgang, C. D., Marsee, D. K., Allen, A. E., and Sivaprasad, U. (1999) ATF3 and stress responses. Gene Expr. 7: 321-335.
16. Kool, J., Hamdi, M., Cornelissen-Steijger, P., van der Eb, A. J., Terleth, C., and van Dam, H. (2003) Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAP kinases and ATF-2. Oncogene 22: 4235-4242.
17. Cano, E., Hazzalin, C. A., and Mahadevan, L. C. (1994) Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol. Cell. Biol. 14: 7352-7362.
18. Liang, G., Wolfgang, C. D., Chen, B. P., Chen, T. H., and Hai, T. (1996) ATF3 gene. Genomic organization, promoter, and regulation. J. Biol. Chem. 271: 1695-1701.
19. Perez, S., Vial, E., van Dam, H., and Castellazzi, M. (2001) Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation. Oncogene 20: 1135-1141.
20. Mashima, T., Udagawa, S., and Tsuruo, T., (2001) Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis. J. Cell. Physiol. 188: 352-358.
21. Fan, F., Jin, S., Amundson, S. A., Tong, T., Fan, W., Zhao, H., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., Fornace Jr., A. J., Rajasekaran, B., and Zhan, Q. (2002) ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 21: 7488-7496.
22. Nobori, K., Ito, H., Tamamori-Adachi, M., Adachi, S., Ono, Y., Kawauchi, J., Kitajima, S., Marumo, F., and Isobe, M. (2002) ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. J. Mol. Cell. Cardiol. 34: 1387-1397.
23. Hartman, M. G., Lu, D., Kim, M. L., Kociba, G. J., Shukri, T., Buteau, J., Wang, X., Frankel, W. L., Guttridge, D., Prentki, M., Grey, S. T., Ron, D., and Hai, T. (2004) Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol. Cell. Biol. 24: 5721-5732.
24. Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Poppelmann, B., Luger, T. A., and Schwarz, T. (1998) Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J. Cell. Biol. 140: 171-182.
25. Leers, M. P., Kolgen, W., Bjorklund, V., Bergman, T., Tribbick, G., Persson, B., Bjorklund, P., Ramaekers, F.C., Bjorklund, B., Nap, M., Jornvall, H., and Schutte, B. (1999) Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J. Pathol. 187: 567-572.
26. Hai, T. W., Liu, F., Coukos, W. J., and Green, M. R. (1989) Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3: 2083-2090.
27. Hai, T. and Curran, T. (1991) Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci., USA. 88: 3720-3724.
28. Hai, T. and Hartman, M. G. (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273: 1-11.
29. Kawauchi, J., Zhang, C., Nobori, K., Hashimoto, Y., Adachi, M.T., Noda, A., Sunamori, M., and Kitajima, S. (2002) Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. J. Biol. Chem. 277: 39025-39034.
30. Okamoto, Y., Chaves, A., Chen, J., Kelley, R., Jones, K., Weed, H. G., Gardner, K. L. Gangi, L., Yamaguchi, M., Klomkleaw, W., Nakayama, T., Hamlin, R. L., Carnes, C., Altschuld, R., Bauer, J., and Hai, T. (2001) Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction. Am. J. Pathol. 159: 639-650.
31. Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., and Hai, T. (2001) The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J. Biol. Chem. 276: 29507-29514.
32. Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., and Hai, T. (2002) The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. J. Biol. Chem. 277: 20020-20025.
33. Allan, A. L., Albanese, C., Pestell, R. G., and LaMarre, J. (2001) Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes. J. Biol. Chem. 276: 27272-27280.
34. Dazard, J. E., Gal, H., Amariglio, N., Rechavi, G., Domany, E., and Givol, D. (2003) Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. Oncogene 22: 2993-3006.
35. Wolfgang, C. D., Chen, B. P., Martindale, J. L., Holbrook, N. J., and Hai, T. (1997) gadd153/Chop10, a potential target gene of the transcriptional repressor ATF3. Mol. Cell. Biol. 17: 6700-6707.