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Volumn 29, Issue 6, 2005, Pages 889-894

Hypothesis: Minimal changes in neural transmission in schizophrenia: Decreased glutamatergic and GABAergic functions in the prefrontal cortex

Author keywords

GABA; Glutamate; Minimal change; mRNA; Pathophysiology; Schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE; DOPAMINE RECEPTOR; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; IONOTROPIC RECEPTOR; MESSENGER RNA; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5;

EID: 23144456211     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2005.04.038     Document Type: Review
Times cited : (23)

References (45)
  • 1
    • 0029876983 scopus 로고    scopus 로고
    • Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients
    • S. Akbarian, J.J. Kim, S.G. Potkin, W.P. Hetrick, W.E. Bunney Jr., and E.G. Jones Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients Arch. Gen. Psychiatry 53 1996 425 436
    • (1996) Arch. Gen. Psychiatry , vol.53 , pp. 425-436
    • Akbarian, S.1    Kim, J.J.2    Potkin, S.G.3    Hetrick, W.P.4    Bunney Jr., W.E.5    Jones, E.G.6
  • 2
    • 0029757375 scopus 로고    scopus 로고
    • Recent advances in defining the neuropathology of schizophrenia
    • S.E. Arnold, and J.Q. Trojanowski Recent advances in defining the neuropathology of schizophrenia Acta Neuropathol. 92 1996 217 231
    • (1996) Acta Neuropathol. , vol.92 , pp. 217-231
    • Arnold, S.E.1    Trojanowski, J.Q.2
  • 4
    • 0023472027 scopus 로고
    • Increased vertical axon numbers in cingulate cortex of schizophrenics
    • F.M. Benes, R. Majocha, E.D. Bird, and C.A. Marotta Increased vertical axon numbers in cingulate cortex of schizophrenics Arch. Gen. Psychiatry 44 1987 1017 1021
    • (1987) Arch. Gen. Psychiatry , vol.44 , pp. 1017-1021
    • Benes, F.M.1    Majocha, R.2    Bird, E.D.3    Marotta, C.A.4
  • 5
    • 0026950781 scopus 로고
    • Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain
    • F.M. Benes, I. Sorensen, S.L. Vincent, E.D. Bird, and M. Sathi Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain Cereb. Cortex 2 1992 503 512
    • (1992) Cereb. Cortex , vol.2 , pp. 503-512
    • Benes, F.M.1    Sorensen, I.2    Vincent, S.L.3    Bird, E.D.4    Sathi, M.5
  • 6
    • 0027283411 scopus 로고
    • Recent advances in the neuropathology of schizophrenia
    • B. Bogerts Recent advances in the neuropathology of schizophrenia Schizophr. Bull. 19 1993 431 445
    • (1993) Schizophr. Bull. , vol.19 , pp. 431-445
    • Bogerts, B.1
  • 8
    • 0027298969 scopus 로고
    • Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats
    • D.A. Daly, and B. Moghaddam Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats Neurosci. Lett. 152 1993 61 64
    • (1993) Neurosci. Lett. , vol.152 , pp. 61-64
    • Daly, D.A.1    Moghaddam, B.2
  • 10
    • 0017339785 scopus 로고
    • High affinity uptake of glutamate in terminals of corticostriatal axons
    • I. Divac, F. Fonnum, and J. Storm-Mathisen High affinity uptake of glutamate in terminals of corticostriatal axons Nature 266 1977 377 378
    • (1977) Nature , vol.266 , pp. 377-378
    • Divac, I.1    Fonnum, F.2    Storm-Mathisen, J.3
  • 11
    • 0002556294 scopus 로고
    • Abnormal mental states induced by phencyclidine as a model of schizophrenia
    • E.F. Domino E.D. Luby NPP Books Michigan
    • E.F. Domino Abnormal mental states induced by phencyclidine as a model of schizophrenia E.F. Domino E.D. Luby PCP (Phencyclidine): Historical and Current Perspectives 1981 NPP Books Michigan 401 418
    • (1981) PCP (Phencyclidine): Historical and Current Perspectives , pp. 401-418
    • Domino, E.F.1
  • 12
    • 0034843740 scopus 로고    scopus 로고
    • N-methyl-d-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    • S. Dracheva, S.A. Marras, S.L. Elhakem, F.R. Kramer, K.L. Davis, and V. Haroutunian N-methyl-d-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia Am. J. Psychiatry 158 2001 1400 1410
    • (2001) Am. J. Psychiatry , vol.158 , pp. 1400-1410
    • Dracheva, S.1    Marras, S.A.2    Elhakem, S.L.3    Kramer, F.R.4    Davis, K.L.5    Haroutunian, V.6
  • 13
    • 0019124464 scopus 로고
    • The release of labeled l-glutamic acid from rat neostriatum in vivo following stimulation of frontal cortex
    • O.V. Godukhin, A.D. Zharikova, and V.I. Novoselov The release of labeled l-glutamic acid from rat neostriatum in vivo following stimulation of frontal cortex Neuroscience 5 1980 2151 2154
    • (1980) Neuroscience , vol.5 , pp. 2151-2154
    • Godukhin, O.V.1    Zharikova, A.D.2    Novoselov, V.I.3
  • 14
    • 0029736547 scopus 로고    scopus 로고
    • Advances in post mortem molecular neurochemistry and neuropathology: Examples from schizophrenia research
    • P.J. Harrison Advances in post mortem molecular neurochemistry and neuropathology: examples from schizophrenia research Br. Med. Bull. 52 1996 527 538
    • (1996) Br. Med. Bull. , vol.52 , pp. 527-538
    • Harrison, P.J.1
  • 16
    • 0026497188 scopus 로고
    • NMDA-associated glycine binding site increases in schizophrenic brains
    • M. Ishimaru, A. Kurumaji, and M. Toru NMDA-associated glycine binding site increases in schizophrenic brains Biol. Psychiatry 32 1992 379 381
    • (1992) Biol. Psychiatry , vol.32 , pp. 379-381
    • Ishimaru, M.1    Kurumaji, A.2    Toru, M.3
  • 17
    • 0028258111 scopus 로고
    • Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis
    • M. Ishimaru, A. Kurumaji, and M. Toru Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: evidence for glutamate hypothesis Biol. Psychiatry 35 1994 84 95
    • (1994) Biol. Psychiatry , vol.35 , pp. 84-95
    • Ishimaru, M.1    Kurumaji, A.2    Toru, M.3
  • 18
    • 0017755782 scopus 로고
    • Effect of frontal cortex ablation on striatal glutamic acid level in rat
    • J.S. Kim, R. Hasller, P. Hau, and K.S. Paik Effect of frontal cortex ablation on striatal glutamic acid level in rat Brain Res. 132 1977 370 374
    • (1977) Brain Res. , vol.132 , pp. 370-374
    • Kim, J.S.1    Hasller, R.2    Hau, P.3    Paik, K.S.4
  • 21
    • 0028785954 scopus 로고
    • Glutamatergic hypothesis of schizophrenia: Psychoses induced by phencyclidine and cortical-subcortical imbalance
    • M.O. Krebs Glutamatergic hypothesis of schizophrenia: psychoses induced by phencyclidine and cortical-subcortical imbalance Encephale 21 1995 581 588
    • (1995) Encephale , vol.21 , pp. 581-588
    • Krebs, M.O.1
  • 22
    • 0026612670 scopus 로고
    • 3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: Minimal changes in postmortem brains of chronic schizophrenics
    • 3H]amino-3- hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics J. Neurochem. 59 1992 829 837
    • (1992) J. Neurochem. , vol.59 , pp. 829-837
    • Kurumaji, A.1    Ishimaru, M.2    Toru, M.3
  • 24
    • 0018841942 scopus 로고
    • Elevation of brain neuroleptic/dopamine receptors in schizophrenia
    • T. Lee, and P. Seeman Elevation of brain neuroleptic/dopamine receptors in schizophrenia Am. J. Psychiatry 137 1980 191 197
    • (1980) Am. J. Psychiatry , vol.137 , pp. 191-197
    • Lee, T.1    Seeman, P.2
  • 26
    • 2342624566 scopus 로고    scopus 로고
    • Microarray reality checks in the context of a complex disease
    • G.L. Miklos, and R. Maleszka Microarray reality checks in the context of a complex disease Nat. Biotechnol. 22 2004 615 621
    • (2004) Nat. Biotechnol. , vol.22 , pp. 615-621
    • Miklos, G.L.1    Maleszka, R.2
  • 27
    • 0020644714 scopus 로고
    • 3H]kainic acid binding in the prefrontal cortex in schizophrenia
    • 3H]kainic acid binding in the prefrontal cortex in schizophrenia Neurosci. Lett. 40 1983 245 250
    • (1983) Neurosci. Lett. , vol.40 , pp. 245-250
    • Nishikawa, T.1    Takashima, M.2    Toru, M.3
  • 28
    • 0032078391 scopus 로고    scopus 로고
    • Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia
    • T. Ohnuma, S.J. Augood, H. Arai, P.J. McKenna, and P.C. Emson Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia Brain Res. Mol. Brain Res. 56 1998 207 217
    • (1998) Brain Res. Mol. Brain Res. , vol.56 , pp. 207-217
    • Ohnuma, T.1    Augood, S.J.2    Arai, H.3    McKenna, P.J.4    Emson, P.C.5
  • 29
    • 0032776814 scopus 로고    scopus 로고
    • Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: Focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression
    • T. Ohnuma, S.J. Augood, H. Arai, P.J. McKenna, and P.C. Emson Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression Neuroscience 93 1999 441 448
    • (1999) Neuroscience , vol.93 , pp. 441-448
    • Ohnuma, T.1    Augood, S.J.2    Arai, H.3    McKenna, P.J.4    Emson, P.C.5
  • 30
    • 0034727417 scopus 로고    scopus 로고
    • Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia
    • T. Ohnuma, H. Kato, H. Arai, R.L. Faull, P.J. McKenna, and P.C. Emson Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia NeuroReport 11 2000 3133 3137
    • (2000) NeuroReport , vol.11 , pp. 3133-3137
    • Ohnuma, T.1    Kato, H.2    Arai, H.3    Faull, R.L.4    McKenna, P.J.5    Emson, P.C.6
  • 31
    • 0037430917 scopus 로고    scopus 로고
    • Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset
    • T. Ohnuma, H. Kato, H. Arai, P.J. McKenna, and P.C. Emson Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset Brain Res. Mol. Brain Res. 112 2003 90 94
    • (2003) Brain Res. Mol. Brain Res. , vol.112 , pp. 90-94
    • Ohnuma, T.1    Kato, H.2    Arai, H.3    McKenna, P.J.4    Emson, P.C.5
  • 33
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • J.W. Olney, and N.B. Farber Glutamate receptor dysfunction and schizophrenia Arch. Gen. Psychiatry 52 1995 998 1007
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 35
    • 0025017081 scopus 로고
    • Hypofrontality and cognitive impairment in schizophrenia: Dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function
    • R.G. Paulman, M.D. Devous Sr., R.R. Gregory, J.H. Herman, L. Jennings, F.J. Bonte, H.A. Nasrallah, and J.D. Raese Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function Biol. Psychiatry 27 1990 377 399
    • (1990) Biol. Psychiatry , vol.27 , pp. 377-399
    • Paulman, R.G.1    Devous Sr., M.D.2    Gregory, R.R.3    Herman, J.H.4    Jennings, L.5    Bonte, F.J.6    Nasrallah, H.A.7    Raese, J.D.8
  • 36
    • 0026293764 scopus 로고
    • Neuronal structure abnormality in the orbito-frontal cortex of schizophrenics
    • D. Senitz, and E. Winkelmann Neuronal structure abnormality in the orbito-frontal cortex of schizophrenics J. Hirnforsch. 32 1991 149 158
    • (1991) J. Hirnforsch. , vol.32 , pp. 149-158
    • Senitz, D.1    Winkelmann, E.2
  • 37
    • 0026323445 scopus 로고
    • Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics
    • A.D. Sherman, T.S. Hegwood, S. Baruah, and R. Waziri Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics Biol. Psychiatry 30 1991 1191 1198
    • (1991) Biol. Psychiatry , vol.30 , pp. 1191-1198
    • Sherman, A.D.1    Hegwood, T.S.2    Baruah, S.3    Waziri, R.4
  • 38
    • 0025720980 scopus 로고
    • Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication
    • M.D. Simpson, P. Slater, M.C. Royston, and J.F. Deakin Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication Schizophr. Res. 6 1991 41 48
    • (1991) Schizophr. Res. , vol.6 , pp. 41-48
    • Simpson, M.D.1    Slater, P.2    Royston, M.C.3    Deakin, J.F.4
  • 39
    • 0031774346 scopus 로고    scopus 로고
    • Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics: Evidence on reversible up-regulation by typical neuroleptics
    • B.P. Sokolov Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics: evidence on reversible up-regulation by typical neuroleptics J. Neurochem. 71 1998 2454 2464
    • (1998) J. Neurochem. , vol.71 , pp. 2454-2464
    • Sokolov, B.P.1
  • 40
    • 0026489330 scopus 로고
    • Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
    • T. Storck, S. Schulte, K. Hofmann, and W. Stoffel Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain Proc. Natl. Acad. Sci. U. S. A. 89 1992 10955 10959
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 10955-10959
    • Storck, T.1    Schulte, S.2    Hofmann, K.3    Stoffel, W.4
  • 41
    • 0017167056 scopus 로고
    • Selective activation of mesocortical DA system by stress
    • A.M. Thierry, J.P. Tassin, G. Blanc, and J. Glowinski Selective activation of mesocortical DA system by stress Nature 263 1976 242 244
    • (1976) Nature , vol.263 , pp. 242-244
    • Thierry, A.M.1    Tassin, J.P.2    Blanc, G.3    Glowinski, J.4
  • 43
    • 0023711759 scopus 로고
    • Speculation on the meaning of cerebral metabolic hypofrontality in schizophrenia
    • D.R. Weinberger, and K.F. Berman Speculation on the meaning of cerebral metabolic hypofrontality in schizophrenia Schizophr. Bull. 14 1988 157 168
    • (1988) Schizophr. Bull. , vol.14 , pp. 157-168
    • Weinberger, D.R.1    Berman, K.F.2
  • 44
    • 0022581021 scopus 로고
    • Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence
    • D.R. Weinberger, K.F. Berman, and R.F. Zec Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence Arch. Gen. Psychiatry 43 1986 114 124
    • (1986) Arch. Gen. Psychiatry , vol.43 , pp. 114-124
    • Weinberger, D.R.1    Berman, K.F.2    Zec, R.F.3
  • 45
    • 0028279808 scopus 로고
    • Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations
    • B.K. Yamamoto, and M.A. Cooperman Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations J. Neurosci. 14 1994 4159 4166
    • (1994) J. Neurosci. , vol.14 , pp. 4159-4166
    • Yamamoto, B.K.1    Cooperman, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.