A convenient and efficient method for the synthesis of mono- and N,N-disubstituted thioureas

Tetrahedron Letters

Volumn 46, Issue 35, 2005, Pages 5841-5843

  Kodomari, Mitsuo ^a   Suzuki, Masato ^a   Tanigawa, Keiko ^a   Aoyama, Tadashi ^b  

^a SHIBAURA INSTITUTE OF TECHNOLOGY   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Debenzoylation; Hydrazine; N Substituted thiourea

Indexed keywords

HYDRAZINE; SOLVENT; THIOUREA DERIVATIVE;

ARTICLE; ROOM TEMPERATURE; SUBSTITUTION REACTION;

EID: 23144431595     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.06.135     Document Type: Article

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23. Silica gel-supported ammonium thiocyanate was prepared as follows. Silica gel (18.48 g) was added to a solution of ammonium thiocyanate (20 mmol 1.52 g) in dry acetonitrile (50 mL), and the mixture was stirred at room temperature for 30 min. The acetonitrile was removed under reduced pressure. The resulting reagent was dried in vacuo (15 mmHg) at room temperature for 3 h.
24. 4. The solvent was evaporated under reduced pressure to leave the crude product, which was purified by recrystallization (methanol).