Synthesis of 1-benzoyl-3-alkylthioureas by transamidation under microwave in dry media

Tetrahedron Letters

Volumn 41, Issue 11, 2000, Pages 1753-1756

  Márquez, Heiddy ^a   Pérez, Eduardo R ^a   Plutín, Ana M ^a   Morales, Margarita ^a   Loupy, André ^b  

^a UNIVERSITY OF HAVANA   (Cuba)

^b UNIVERSITÉ PARIS SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

THIOUREA DERIVATIVE;

ALKALINITY; AMIDATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; IONIZATION; MICROWAVE IRRADIATION; REACTION ANALYSIS; TEMPERATURE SENSITIVITY;

EID: 0342804511     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00047-2     Document Type: Article

References (14)

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10. Typical procedure: 1-benzoyl-3,3-diethylthiourea 1 (2 mmol) was dissolved in acetone. An equimolar amount of the indicated amines were then added and the mixture then smoothly mixed with 1 g of KF-alumina. The solvent was removed under reduced pressure. The resulting mixture was placed into a Pyrex-glass open vessel and irradiated in a microwave domestic oven at 560 W for the times and final temperatures as indicated in Tables 1 and 2. The products were extracted from the support with acetone and precipitated with ice water.
11. Plutín, A. M. M.Sc. Thesis Estudio de la alquilación de un sistema polidentado: 1-aciltioureas - 3,3-disustituidas; University of Havana, Cuba, 1997.
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