In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 1, 2005, Pages 103-110

  Lee, Myong Gyong ^a   Phimister, Andrew ^a   Morin, Dexter ^a   Buckpitt, Alan ^a   Plopper, Charles ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NAPHTHALENE;

ACUTE DISEASE; AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; COMPARATIVE STUDY; CORRELATION ANALYSIS; EXPOSURE; FACIAL BONE; FILTRATION; INCIDENCE; INHALATION; INJECTION; MALE; METABOLIC RATE; METABOLISM; MICROSOME; MIDDLE EAR; NONHUMAN; NOSE AIRFLOW; NOSE INJURY; NOSE MUCOSA; NOSE SEPTUM; NOSE TUMOR; OLFACTORY EPITHELIUM; OLFACTORY SYSTEM; PRIORITY JOURNAL; RAT; RAT STRAIN; SIMULATION; STANDARD; TIME;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; INHALATION EXPOSURE; INJECTIONS, INTRAPERITONEAL; MALE; MICROSOMES; NAPHTHALENES; NASAL CAVITY; NASAL MUCOSA; PULMONARY VENTILATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 23044515789     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.084517     Document Type: Article

References (28)

1. Agency for Toxic Substances and Disease Registry (2003) Chemical and physical information, in Toxicological Profile for Naphthalene, 1-Methylnaphthalene, and 2-Methylnaphthalene.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Buckpitt A, Buonarati M, Avey LB, Chang AM, Morin D, and Plopper CG (1992) Relationship of cytochrome P450 activity to Clara cell cytotoxicity. II. Comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey. J Pharmacol Exp Ther 261:364-372.
4. Buckpitt AR, Castagnoli N Jr, Nelson SD, Jones AD, and Bahnson LS (1987) Stereoselectivity of naphthalene epoxidation by mouse, rat, and hamster pulmonary, hepatic and renal microsomal enzymes. Drug Metab Dispos 15:491-498.
5. Buckpitt A, Chang AM, Weir A, Van Winkle L, Duan X, Philpot R, and Plopper C (1995) Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of NA and NA oxide in microdissected airways from mice, rats and hamsters. Mol Pharmacol 47:74-81.
6. Chen Y, Liu Y, Su T, Ren X, Shi L, Liu D, Gu J, Zhang Q, and Ding X (2003) Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa. Biochem Pharmacol 66:1245-1251.
7. Ding X and Dahl A (2003) Olfactory mucosa: composition, enzymatic localization and metabolism, in Handbook of Olfaction and Gustation, 2nd ed (Doty RL ed) pp 51-73, Marcel Dekker, New York.
8. Gervasi PG, Longo V, Naldi F, Panattoni G, and Ursino F (1991) Xenobioticmetabolizing enzymes in human respiratory nasal mucosa. Biochem Pharmacol 41:177-184.
9. Gu J, Su T, Chen Y, Zhang QY, and Ding X (2000) Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity. Toxicol Appl Pharmacol 165:158-162.
10. Gu J, Walker VE, Lipinskas TW, Walker DM, and Ding X (1997) Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa. Toxicol Appl Pharmacol 146:134-143.
11. Hardisty JF, Garman RH, Harkema JR, Lomax LG, and Morgan KT (1999) Histopathology of nasal olfactory mucosa from selected inhalation toxicity studies conducted with volatile chemicals. Toxicol Pathol 27:618-627.
12. Harkema JR, Hotchkiss JA, Barr EB, Bennett CB, Gallup M, Lee JK, and Basbaum C (1999) Long-lasting effects of chronic ozone exposure on rat nasal epithelium. Am J Respir Cell Mol Biol 20:517-529.
13. Hubal EA, Schlosser PM, Conolly RB, and Kimbell JS (1997) Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages. Toxicol Appl Pharmacol 143:47-55.
14. International Agency for Research on Cancer (IARC) (2002) Monographs on the evaluation of carcinogenic risks to humans: some traditional herbal medicines, some mycotoxins, NA and styrene. Vol 82, IARC, Lyon, France.
15. Jaeschke H and Wendel A (1985) Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content. Biochem Pharmacol 34:1029-1033.
16. Kimbell JS, Godo MN, Gross EA, Joyner DR, Richardson RB, and Morgan KT (1997) Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol Appl Pharmacol 145:388-398.
17. Kimbell JS, Gross EA, Joyner DR, Godo MN, and Morgan KT (1993) Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol Appl Pharmacol 121:253-263.
18. Longo V, Pacifici GM, Panattoni G, Ursino F, and Gervasi PG (1989) Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver. Biochem Pharmacol 38:1867-1869.
19. Mery S, Gross EA, Joyner DR, Godo N, and Morgan KT (1994) Nasal diagram: a tool for recording the distribution of nasal lesions in rats and mice. Toxicol Pathol 22:353-372.
20. Moulin FJ, Brenneman KA, Kimbell JS, and Dorman DC (2002) Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in rats. Toxicol Sci 66:7-15.
21. National Toxicology Program (NTP) (2000) Toxicology and carcinogenesis studies of NA (CAS no. 91-20-3) in F344/N rats (inhalation studies), in NTP Technical Report No. 500; National Institutes of Health Publication No. 01-4434, Research Triangle Park, NC.
22. Placke ME, Wyand DS, and Cohen SD (1987) Extrahepatic lesions induced by acetaminophen in the mouse. Toxicol Pathol 15:381-387.
23. Plopper CG, Suverkropp C, Morin D, Nishio S, and Buckpitt A (1992) Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of NA. J Pharmacol Exp Ther 261:353-363.
24. Schenkman JB and Jansson I (1999) Measurement of cytochrome P-450, in Current Protocols in Toxicology (Maines MD ed) pp 4.1.1- 4.1.14, John Wiley & Sons, Hoboken, NJ.
25. Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, and Ding X (2000) Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res 60:5074-5079.
26. Thornton-Manning JR and Dahl AR (1997) Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes. Mutat Res 380:43-59.
27. Weiler E and Farbman AI (2003) The septal organ of the rat during postnatal development. Chem Senses 28:581-593.
28. Young JT (1981) Histopathologic examination of the rat nasal cavity. Fundam Appl Toxicol 1:309-312.