Laboratory diagnosis of 1,4-BD and GHB overdose by routine urine organic acid analysis [4]

Clinical Toxicology

Volumn 43, Issue 4, 2005, Pages 321-323

  Quang, Lawrence S ^a,b   Levy, Harvey L ^c   Law, Terence ^c   Desai, Malhar C ^d   Maher, Timothy J ^d   Boyer, Edward W ^c   Shannon, Michael W ^c   Woolf, Alan D ^c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b Children's Hospital Boston/Harvard Medical School ^*  (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BUTANEDIOL; 4 AMINOBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID; CARBOXYLIC ACID; GROWTH HORMONE;

APNEA; BIOTRANSFORMATION; BLOOD ANALYSIS; COMA; DIET SUPPLEMENTATION; DRUG OVERDOSE; GAS CHROMATOGRAPHY; HUMAN; LABORATORY DIAGNOSIS; LETTER; MASS SPECTROMETRY; MEDICAL EXAMINATION; NONHUMAN; RESPIRATION DEPRESSION; URINALYSIS;

EID: 23044506578     PISSN: 07313810     EISSN: 10979875     Source Type: Journal    
DOI: 10.1081/CLT-200058932     Document Type: Letter

References (10)

1. Maitre M. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol 1997; 51:337-361.
2. Takahara J, Yunoki S, Yakushiji W, Yamauchi J, Yamane Y. Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans. J Clin Endocrinol Metab 1977; 44(5):1014-1017.
3. Shannon MW, Quang LS. Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature. Pediatr Emerg Care 2000; 16(6):435-440.
4. Zvosec DL, Smith SW, McCutcheon JR, Spillane J, Hall BJ, Peacock EA. Adverse events, including death, associated with the use of 1,4-butanediol. N Engl J Med 2001; 344(2):87-94.
5. Tancredi DN, Shannon MS. Case 30-2003: a 21-year-old man with sudden alteration of mental status. N Engl J Med 2003; 349:1267-1275.
6. Http://www.usdoj.gov/dea/deadiversion/fed_regs/sched_actions/2000/ fr0313.html, (accessed July 2001).
7. Http://www.nida.nih.gov/CEWG/AdvancedRep/60ladv.html, (accessed August 2001).
8. Quang LS, Desai MC, Kraner JC, Shannon MW, Woolf AD, Maher TJ. Enzyme and receptor antagonists for preventing toxicity from the gamma-hydroxybutyric acid precursor, 1,4-butanediol, in CD-1 mice. Ann N Y Acad Sci 2001; 965:461-472.
9. Quang LS, Shannon MW, Desai MC, Woolf AD, Maher TJ. Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. Life Sci 2002; 71(7):771-778.
10. Quang LS, Desai MC, Shannon MW, Woolf AD, Maher TJ. 4-Methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to gamma-hydroxybutyric acid. Ann N Y Acad Sci 2004; 1025:528-537.