4-Methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to γ-hydroxybutyric acid

Annals of the New York Academy of Sciences

Volumn 1025, Issue , 2004, Pages 528-537

  Quang, Lawrence S ^a,b,c   Desai, Malhar C ^b   Shannon, Michael W ^a,b   Woolf, Alan D ^a,b   Maher, Timothy J ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MA Coll of Pharm and Hlth Sci   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

1,4 butanediol (1,4 BD); 4 methylpyrazole (4 MP); Alcohol dehydrogenase (ADH); hydroxybutyric acid (GHB)

Indexed keywords

1,4 BUTANEDIOL; 4 HYDROXYBUTYRIC ACID; 4 METHYLPYRAZOLE; ANTIDOTE;

ANIMAL EXPERIMENT; BIOTRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RIGHTING REFLEX;

ANIMALIA; MURINAE;

EID: 10444271794     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1316.065     Document Type: Conference Paper

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