Tumor targeted gene therapy with plasmid expressing human tumor necrosis factor alpha in vitro and in vivo

Neoplasma

Volumn 52, Issue 4, 2005, Pages 344-351

  Pastorakova, A ^a   Hlubinova, K ^a   Bodo, J ^a   Libby, J ^b   Rychly, B ^c   Margison, G ^b   Altaner, C ^a  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c Derer 's University Hospital Slovakia   (Slovakia)

Author keywords

Apoptosis; Cancer gene therapy; Human tumor necrosis factor alpha; Necrosis

Indexed keywords

PROCASPASE 3; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER; CANCER CELL CULTURE; COLON CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVATION; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE THERAPY; GENETIC TRANSFECTION; GLIOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; TUMOR NECROSIS; WESTERN BLOTTING; XENOGRAFT;

EID: 23044502977     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. BEUTLER B, CERAMI A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 1986; 320: 584-588.
2. BEUTLER B, VAN HC. Unraveling function in the TNF ligand and receptor families. Science 1994; 264: 667-668.
3. BISWAS DK, MARTIN KJ, MCALISTER C, CRUZ AP, GRANER E et al. Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation. Cancer Res 2003; 63: 290-295.
4. BRADHAM CA, QIAN T, STREETZ K, TRAUTWEIN C, BRENNER DA et al. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol 1998; 18: 6353-6364.
5. CARSWELL EA, OLD LJ, KASSEL RL, GREEN S, FIORE N et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 1975; 72: 3666-3670.
6. CHAWLA-SARKAR M, LINDNER DJ, LIU YF, WILLIAMS BR, SEN GC et al. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003; 8: 237-249.
7. DENG Y, REN X, YANG L, LIN Y, WU X. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 2003; 115:61-70.
8. FAJARDO LF, KWAN HH, KOWALSKI J, PRIONAS SD, ALLISON AC. Dual role of tumor necrosis factor-alpha in angiogenesis. Am J Pathol 1992; 140: 539-544.
9. FUKUMURA D, SALEHI HA, WITWER B, TUMA RF, MELDER RJ et al. Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain. Cancer Res 1995; 55: 4824-4829.
10. FUMAROLA C, GUIDOTTI GG. Stress-induced apoptosis: toward a symmetry with receptor-mediated cell death. Apoptosis 2004; 9: 77-82.
11. HLAVATY J, TYUKOSOVA S, BIES J, HLUBINOVA K, ALTANER C. Retrovirus vector containing wild type p53 gene and its effect on human glioma cells. Neoplasma 2000; 47: 204-211.
12. KARLSSON T, HENRIKSSON R, HEDMAN H. Induction of apoptosis in resistant glioma cells by synthetic caspase-activation. J Neurooncol 2004; 66: 71-79.
13. KIM MH, BILLIAR TR, SEOL DW. The secretable form of trimeric TRAIL, a potent inducer of apoptosis. Biochem Biophys Res Commun 2004; 321: 930-935.
14. KIRCHEIS R, OSTERMANN E, WOLSCHEK MF, LICHTEN-BERGER C, MAGIN-LACHMANN C et al. Tumor-targeted gene delivery of tumor necrosis factor-alpha induces tumor necrosis and tumor regression without systemic toxicity. Cancer Gene Ther 2002; 9: 673-680.
15. KIRCHEIS R, WIGHTMAN L, KURSA M, OSTERMANN E, WAGNER E. Tumor-targeted gene delivery: an attractive strategy to use highly active effector molecules in cancer treatment. Gene Ther 2002; 9: 731-735.
16. LANS TE, BARTLETT DL, LIBUTTI SK, GNANT MF, LIEWEHR DJ et al. Role of tumor necrosis factor on toxicity and cytokine production after isolated hepatic perfusion. Clin Cancer Res 2001; 7: 784-790.
17. LASEK W, MACKIEWICZ A, CZAJKA A, SWITAJ T, GOLB J et al. Antitumor effects of the combination therapy with TNF-alpha gene-modified tumor cells and interleukin 12 in a melanoma model in mice. Cancer Gene Ther 2000; 7: 1581-1590.
18. MARR RA, HITT M, MULLER WJ, GAULDIE J, GRAHAM FL. Tumour therapy in mice using adenovirus vectors expressing human TNFα. Int J Oncol 1998; 12: 509-515.
19. MCINTOSH JK, MULE JJ, TRAVIS WD, ROSENBERG SA. Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice. Cancer Res 1990; 50: 2463-2469.
20. MEYAR-ZAZOUA M, LAROCHETTE N, DOROTHEE G, DAUGAS E, HADDADA H et al. Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells: role of caspase-8 and mitochondria. Cancer Gene Ther 2002; 9: 219-227.
21. OTSUKA G, NAGAYA T, SAITO K, MIZUNO M, YOSHIDA J et al. Inhibition of nuclear factor-kappaB activation confers sensitivity to tumor necrosis factor-alpha by impairment of cell cycle progression in human glioma cells. Cancer Res 1999; 59: 4446-1452.
22. RASMUSSEN H, RASMUSSEN C, LEMPICKI M, DURHAM R, BROUGH D et al. TNFerade Biologic: preclinical toxicology of a novel adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene. Cancer Gene Ther 2002; 9: 951-957.
23. REMICK DG, KUNKEL RG, LARRICK JW, KUNKEL SL. Acute in vivo effects of human recombinant tumor necrosis factor. Lab Invest 1987; 56: 583-590.
24. RENARD N, LIENARD D, LESPAGNARD L, EGGERMONT A, HEIMANN R et al. Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha). Int J Cancer 1994; 57: 656-663.
25. ROBAYE B, MOSSELMANS R, FIERS W, DUMONT JE, GALAND P. Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro. Am J Pathol 1991; 138: 447-453.
26. ROTHE J, GEHR G, LOETSCHER H, LESSLAUER W. Tumor necrosis factor receptors - structure and function. Immunol Res 1992; 11: 81-90.
27. SAAS P, BOUCRAUT J, QUIQUEREZ AL, SCHNURIGER V, PERRIN G et al. CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation? J Immunol 1999; 162: 2326-2333.
28. SCHMELZ K, WIEDER T, TAMM I, MULLER A, ESSMANN F et al. Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB. Oncogene 2004; 23: 6743-6759.
29. SENZER N, MANI S, ROSEMURGY A, NEMUNAITIS J, CUNNINGHAM C et al. TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors. J Clin Oncol 2004; 22: 592-601.
30. SIDHU RS, BOLLON AP. Tumor necrosis factor activities and cancer therapy - a perspective. Pharmacol Ther 1993; 57: 79-128.
31. SONG HY, REGNIER CH, KIRSCHNING CJ, GOEDDEL DV, ROTHE M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 1997; 94: 9792-9796.
32. SPYRIDOPOULOS I, PRINCIPE N, KRASINSKI KL, XU S, KEARNEY M et al. Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-alpha-induced apoptosis. Circulation 1998; 98: 2883-2890.
33. SUGARMAN BJ, AGGARWAL BB, HASS PE, FIGARI IS, PALLADINO MA, JR. et al. Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 1985; 230: 943-945.
34. VAN DE WIEL PA, BLOKSMA N, KUPER CF, HOFHUIS FM, WILLERS JM. Macroscopic and microscopic early effects of tumour necrosis factor on murine Meth A sarcoma, and relation to curative activity. J Pathol 1989; 157: 65-73.
35. WALLACH D, BOLDIN M, VARFOLOMEEV E, BEYAERT R, VANDENABEELE P et al. Cell death induction by receptors of the TNF family: towards a molecular understanding. FEBS Lett 1997; 410: 96-106.
36. WANG CY, MAYO MW, BALDWIN AS, JR. TNF-α and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996; 274: 784-787.
37. WATANABE N, NIITSU Y, UMENO H, KURIYAMA H, NEDA H et al. Toxic effect of tumor necrosis factor on tumor vasculature in mice. Cancer Res 1988; 48: 2179-2183.
38. WELLER M, FREI K, GROSCURTH P, KRAMMER PH, YONEKAWA Y et al. Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. J Clin Invest 1994; 94: 954-964.
39. YANG L, CAO Z, YAN H, WOOD WC. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Res 2003; 63: 6815-6824.