An aggrecanase and osteoarthritis

New England Journal of Medicine

Volumn 353, Issue 5, 2005, Pages 522-523

  Karsenty, Gerard ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE; DISINTEGRIN; METALLOPROTEINASE; PROTEOGLYCAN; THROMBOSPONDIN; ADAM PROTEIN; ADAMTS5 PROTEIN, MOUSE; AGC1 PROTEIN, MOUSE; AGGRECANASE 1; AGGRECANASE-1; COLLAGEN TYPE 2; LECTIN; PROCOLLAGEN N PROTEINASE; PROTEINASE; SCLEROPROTEIN;

ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; DISEASE COURSE; EXTRACELLULAR MATRIX; MOUSE MUTANT; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; ANIMAL; ARTICLE; DISEASE MODEL; ENZYMOLOGY; METABOLISM; MOUSE;

ADAM PROTEINS; AGGRECANS; ANIMALS; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; LECTINS, C-TYPE; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEOGLYCANS;

EID: 23044491140     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr051399     Document Type: Short Survey

References (2)

1. Stanton H, Rogerson FM, East CJ, et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 2005; 434:648-52.
2. Glasson SS, Askew R, Sheppard B, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005;434:644-8.