Effect of pregnancy on a measure of FMO3 activity

British Journal of Clinical Pharmacology

Volumn 60, Issue 2, 2005, Pages 224-226

  Hukkanen, Janne ^b   Dempsey, Delia ^b   Jacob III, Peyton ^b   Benowitz, Neal L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBIMAZOLE; CIMETIDINE; CLOZAPINE; COTININE; CYTOCHROME P450 2A6; DRUG METABOLITE; DRUG METABOLIZING ENZYME; FLAVIN CONTAINING MONOOXYGENASE 3; LIVER ENZYME; MICROSOME ENZYME; NICOTINE; RANITIDINE; SEX HORMONE; TAMOXIFEN; THIAMAZOLE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME INDUCTION; GAS CHROMATOGRAPHY; HUMAN; KIDNEY CLEARANCE; LETTER; MASS SPECTROMETRY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; URINE PH;

ANTIOXIDANTS; CYCLIC N-OXIDES; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; NICOTINE; OXYGENASES; PREGNANCY;

EID: 23044484285     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2005.02406.x     Document Type: Letter

References (17)

1. Cashman JR, Zhang J. Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab Dispos 2002; 30: 1043-52.
2. Overby LH, Carver GC, Philpot RM. Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chem Biol Interact 1997; 106: 29-45.
3. Cashman JR, Park SB, Yang ZC, Wrighton SA, Jacob 3rd P, Benowitz NL. Metabolism of nicotine by human liver microsomes. stereoselective formation of trans-nicotine N′-oxide. Chem Res Toxicol 1992; 5: 639-46.
4. Park SB, Jacob III P, Benowitz NL, Cashman JR. Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1′-oxide. Chem Res Toxicol 1993; 6: 880-8.
5. Ayesh R, Al-Waiz M, Crothers J, Cholerton S, Mitchell SC, Idle JR, Smith RL. Deficient nicotine N-oxidation in two sisters with trimethylaminuria. Br J Clin Pharmacol 1988; 25: 664-5.
6. Cholerton S, Ayesh R, Idle JR, Smith RL. The pre-eminence of nicotine N-oxidation and its diminution after carbamizole administration. Br J Clin Pharmacol 1988; 26: 652-3.
7. Dempsey D, Jacob P. 3rd, Benowitz NL. Accelerated metabolism of nicotine and cotinine in pregnant smokers. J Pharmacol Exp Ther 2002; 301: 594-8.
8. Nakajima M, Kuroiwa Y, Yokoi T. Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6. Drug Metab Rev 2002; 34: 865-77.
9. Maikranz P, Holley JL, Parks JH, Lindheimer MD, Nakagawa Y, Coe FL. Gestational hypercalciuria causes pathological urine calcium oxalate supersaturations. Kidney Int 1989; 36: 108-13.
10. Skellern GG, Knight BI, Otter M, Low CK, Alexander WD. The pharmacokinetics of methimazole in pregnant patients after oral administration of carbimazole. Br J Clin Pharmacol 1980; 9: 145-7.
11. Williams DE, Meyer HH, Dutchuk MS. Distinct pulmonary and hepatic forms of flavin-containing monooxygenase in sheep. Comp Biochem Physiol B 1989; 93: 465-70.
12. Lee MY, Smiley S, Kadkhodayan S, Hines RN, Williams DE. Developmental regulation of flavin-containing monooxygenase (FMO) isoforms 1 and 2 in pregnant rabbit. Chem Biol Interact 1995; 96: 75-85.
13. Chung WG, Kang JH, Park CS, Cho MH, Cha YN. Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism. Clin Pharmacol Ther 2000; 67: 258-66.
14. Kang JH, Chung WG, Lee KH, Park CS, Kang JS, Shin IC, Roh HK, Dong MS, Baek HM, Cha YN. Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FMO3 gene mutations in a Korean population. Pharmacogenetics 2000; 10: 67-78.
15. Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, Hines RN. Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. Pediatr Res 2002; 51: 236-43.
16. Zhang AQ, Mitchell SC, Smith RL. Exacerbation of symptoms of fish-odour syndrome during menstruation. Lancet 1996; 348: 1740-1.
17. Yamazaki H, Fujieda M, Togashi M, Saito T, Preti G, Cashman JR, Kamataki T. Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients. Life Sci 2004; 74: 2739-47.