Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FMO3 gene mutations in a Korean population

Pharmacogenetics

Volumn 10, Issue 1, 2000, Pages 67-78

  Kang, Ju Hee ^b   Chung, Woon Gye ^b   Lee, Kyung Hoon ^b   Park, Chang Shin ^b   Kang, Ju Seop ^b   Shin, In Chul ^b   Roh, Hyung Keun ^b   Dong, Mi Sook ^b   Baek, Hyun Moon ^b   Cha, Young Nam ^a  

^a Inha University School of Medicine   (South Korea)

^b NONE

Author keywords

FMO3; Genotype; Korean; Linkage; Phenotype; Ranitidine

Indexed keywords

DIMETHYLANILINE MONOOXYGENASE; RANITIDINE;

ADULT; ARTICLE; ENZYME ACTIVITY; ENZYME METABOLISM; FEMALE; GENE MAPPING; GENE MUTATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; KOREA; MALE; NORMAL HUMAN; OXIDATION; PHENOTYPE; POPULATION GENETICS; PRIORITY JOURNAL; SMOKING; URINALYSIS;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; KOREA; LINKAGE (GENETICS); MALE; MUTATION; OXIDATION-REDUCTION; OXYGENASES; PHENOTYPE; RANITIDINE; REFERENCE VALUES; SEX FACTORS; SMOKING;

EID: 0034053228     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200002000-00009     Document Type: Article

References (26)

1. Al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. Trimethylaminuria (fish-odor syndrome): an inborn error of oxidation metabolism. Lancet 1987a; 1:634-635.
2. Al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. A genetic polymorphism of the N-oxidation of trimethylamine in humans. Clin Pharmacol Ther 1987b: 42:588-594.
3. Al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans - a pharmacogenetic approach. Clin Pharmacol Ther 1987c; 42:608-612.
4. Ayesh R, Mitchell SC, Zhang A, Smith RL. The Fish-odor syndrome: biochemical, familial and clinical aspects. Br Med J 1993; 307:655-657.
5. Brunelle A, Bi Y-A, Lin J, Russell B, Luy L, Berkman C, Cashman J. Characterization of two human flavin-containing monooxygenase (form 3) enzymes expressed in Eschericia coli as maltose binding protein fusions. Drug Metab Dispos 1997; 25:1001-1007.
6. Carey PF, Martin LE, Owen PE. Determination of ranitidine and its metabolites in human urine by reversed-phase ion-pair high-performance liquid chromatography. J Chromatogr 1981; 225:161-168.
7. Cashman JR, Yang ZC, Yang L, Wrighton S. Stereo-and regioselective N-and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes. Drug Metab Dispos 1993; 21:492-501.
8. Cashman JR. Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem Res Toxicol 1995; 8:165-181.
9. Cashman JR, Bi Y-A, Lin J, Youil R, Knight M, Forrest S, Treacy E. Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria. Chem Res Toxicol 1997; 10:837-841.
10. Chung WG, Cha YN. Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes. Biochem Biophys Res Commun 1997; 235:685-688.
11. de la Huerga J, Popper H. Urinary excretion of choline metabolites following choline administration in normals and patients with hepatobiliary diseases. J Clin Invest 1951; 30:463-470.
12. Dolphin CT, Cullingford TE, Shephard EA, Smith RL, Phillips IR. Differential development and tissue-specific regulation of expression of the gene encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FMO4. Eur J Biochem 1996; 235:683-689.
13. Dolphin CT, Janmohamed A, Smith RL, Shephard EA, Phillips IR. Missense mutation in flavin-containing monooxygenase 3 gene, FMO3, underlies fish-odor syndrome. Nature Genet 1997; 17:491-494.
14. Endrenyi L, Patel M. A new, sensitive graphical method for detecting deviations from the normal distribution of drug responses: the NTV plot. Br J Clin Pharmacol 1991; 32:159-166.
15. Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM. The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. Toxicol Appl Pharmacol 1994; 125:1-6.
16. Lomri N, Gu Q, Cashman JR. Molecular cloning of the human liver flavin-containing monooxygenase form II cDNA: structure and expression. Prof Natl Acad Sci USA 1992; 89:1685-1689.
17. Martin LE, Oxford J, Tanner RJ. The use of on-line high-performance liquid chromatography-mass spectrometry for the identification of ranitidine and its metabolites in urine. Xenobiotica 1981; 11:831-840.
18. Overby LH, Carver GC, Philpot RM. Quantitative and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenase 3 and 5 from humans. Chem Biol Interact 1997; 106:29-45.
19. Park CS, Chung WG, Kang JH, Roh HK, Lee KH, Cha YN. Phenotyping of flavin-containing monooxygenase using caffeine metabolism and genotyping of FMO3 gene in a Korean population. Pharmacogenetics 1999; 9:155-164.
20. Patel M, Tang BK, Kalow W. Variability of acetaminophen metabolism in Caucasians and Orientals. Pharmacogenetics 1992; 2:38-45.
21. Roberts CJ. Clinical pharmacokinetics of ranitidine. Clin Pharmacokinet 1984; 9:211-221.
22. Shinn AF. Clinical relevance of cimetidine drug interactions. Drug Safety 1992; 7:245-267.
23. 2 receptor antagonists in the treatment of gastroesophageal reflux disease and its symptoms. Can J Gastroenterol 1997; 11:51B-54B.
24. Ziegler DM. Flavin-containing monooxygenase: catalytic mechanism and substrate specificities. Drug Metab Rev 1988; 19:1-32.
25. Ziegler DM. Flavin-containing monooxygenase: enzymes adapted for multisubstrate specificity. Trends Pharmacol Sci 1990; 11:321-324.
26. Ziegler DM. Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases. Annu Rev Pharmacol Toxicol 1993; 33:179-199.