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Droperidol in the emergency department: Is it safe?
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Richards JR, Schneir AB. Droperidol in the emergency department: is it safe? J Emerg Med 2003; 24:441-447.
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J Emerg Med
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A model for evaluating droperidol's effect on the median QTc interval
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Zhang Y, Luo Z, White PF. A model for evaluating droperidol's effect on the median QTc interval. Anesth Analg 2004; 98:1330-1335. The authors make use of a mathematical model to evaluate the relationship between the dose of droperidol and QT(c) prolongation.
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Anesth Analg
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Zhang, Y.1
Luo, Z.2
White, P.F.3
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QTc interval prolongation associated with intravenous methadone
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Kornick CA, Kilborn MJ, Santiago-Raima J, et al. QTc interval prolongation associated with intravenous methadone. Pain 2003; 105:499-506.
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Kornick, C.A.1
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Droperidol, QT prolongation, and sudden death: What is the evidence?
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Kao LW, Kirk MA, Evers SJ, Rosenfeld SH. Droperidol, QT prolongation, and sudden death: what is the evidence? Ann Emerg Med 2003; 41:546-558.
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Ann Emerg Med
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Kao, L.W.1
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2442662544
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Novel therapeutics for treatment of long-QT syndrome and torsade de pointes
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Khan IA, Gowda RM. Novel therapeutics for treatment of long-QT syndrome and torsade de pointes. Int J Cardiol 2004; 95:1-6. The authors speculate on future therapeutic strategies for the treatment of LQTS and TdP. These include sodium antagonists, potassium channel activators and protein kinase inhibitors.
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Int J Cardiol
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Khan, I.A.1
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Electrocardiographic manifestations: Long QT syndrome
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Mancuso EM, Brady WJ, Harrigan RA, et al. Electrocardiographic manifestations: long QT syndrome. J Emerg Med 2004; 27:385-393. The authors describe the epidemiology and pathophysiology, the clinical presentation, the electrocardiographic manifestations, the diagnosis and management of LQTS.
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J Emerg Med
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Mancuso, E.M.1
Brady, W.J.2
Harrigan, R.A.3
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9
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Congenital and acquired long QT syndrome. Current concepts and management
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Chiang CE. Congenital and acquired long QT syndrome. Current concepts and management. Cardiol Rev 2004; 12:222-234. The author reviews the current concepts and management of congenital and acquired LQTS.
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Cardiol Rev
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Chiang, C.E.1
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10
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Molecular basis of congenital and acquired long QT syndromes
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Ackerman MJ. Molecular basis of congenital and acquired long QT syndromes. J Electrocardiol 2004; 37(Suppl. 1):1-6. The author discusses the molecular basis of congenital and acquired LQTS. The different phenotypes are detailed, and the medical conditions and drugs associated with acquired LQTS mentioned.
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J Electrocardiol
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Ackerman, M.J.1
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11
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Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome
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Gong Q, Keeney DR, Robinson JC, Zhou Z. Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome. J Mol Cell Biol 2004; 37:1225-1233.
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J Mol Cell Biol
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Gong, Q.1
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Robinson, J.C.3
Zhou, Z.4
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12
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2942527155
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Torsade de pointes: The clinical considerations
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Gowda RM, Khan IA, Wilbur SL, et al. Torsade de pointes: the clinical considerations. Int J Cardiol 2004; 96:1-6. The authors explore the electrophysiological mechanisms of LQTS and the development of TdP.
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Int J Cardiol
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Gowda, R.M.1
Khan, I.A.2
Wilbur, S.L.3
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13
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Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts
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Chiba K, Sugiyama A, Takasuna K, Hashimoto K. Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts. Eur J Pharmacol 2004; 502:117-122.
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Eur J Pharmacol
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Chiba, K.1
Sugiyama, A.2
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14
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Drug-induced QT interval prolongation: Regulatory perspectives and drug development
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Shah RR. Drug-induced QT interval prolongation: regulatory perspectives and drug development. Ann Med 2004; 36(Suppl. 1):47-52.
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Ann Med
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Shah, R.R.1
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Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: The role of experimental models
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Joshi A, Dimino T, Vohra Y, et al. Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models. J Electrocardiol 2004; 37(Suppl. 1):7-14. The authors discuss the preclinical strategies designed to assess the QT liability and torsadogenic potential of new drugs. Of special importance is the use of the rabbit left ventricle wedge preparation that exhibits high sensitivity and specificity for the identification of compounds positive and negative for QT prolongation and TdP.
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J Electrocardiol
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Joshi, A.1
Dimino, T.2
Vohra, Y.3
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16
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Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models
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Satoh Y, Sugiyama A, Takahara A, et al. Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models. J Cardiovasc Pharmacol 2004; 43:715-723.
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Satoh, Y.1
Sugiyama, A.2
Takahara, A.3
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Optimal administration dosage of magnesium sulfate for torsades de pointes in children with long QT syndrome
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Hoshino K, Ogawa K, Hishitani T, et al. Optimal administration dosage of magnesium sulfate for torsades de pointes in children with long QT syndrome. J Am Coll Nutr 2004; 23:4975-5008.
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Hoshino, K.1
Ogawa, K.2
Hishitani, T.3
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Ventricular tachycardia during general anesthesia in a patient with congenital long QT syndrome
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Katz RI, Quijano I, Barcelon N, Biancaniello T. Ventricular tachycardia during general anesthesia in a patient with congenital long QT syndrome. Can J Anaesth 2003; 50:398-403.
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Can J Anaesth
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Katz, R.I.1
Quijano, I.2
Barcelon, N.3
Biancaniello, T.4
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20
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Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol
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Kleinsasser A, Loeckinger A, Lindner KH, et al. Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol. Anaesthesia 2001; 56:248-250.
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Anaesthesia
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Kleinsasser, A.1
Loeckinger, A.2
Lindner, K.H.3
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21
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0038351042
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QT dispersion increases during intubation in patients with coronary artery disease
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Ay B, Fak AS, Toprak A, et al. QT dispersion increases during intubation in patients with coronary artery disease. J Electrocardiol 2003; 36:99-104.
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J Electrocardiol
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Ay, B.1
Fak, A.S.2
Toprak, A.3
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22
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QT interval and QT dispersion during the induction of anaesthesia in patients with subarachnoid haemorrhage: A comparison of thiopental and propofol
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Tanskanen PE, Kytta JV, Randell TT. QT interval and QT dispersion during the induction of anaesthesia in patients with subarachnoid haemorrhage: a comparison of thiopental and propofol. Eur J Anaesthesiol 2002; 19:749-754.
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Tanskanen, P.E.1
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The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG
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Yildirim H, Adanir T, Atay A, et al. The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG. Eur J Anaesthesiol 2004; 21:566-570.
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Yildirim, H.1
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24
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Comparison of single-breath vital capacity rapid inhalation with sevoflurane 5% and propofol induction on QT interval and haemodynamics for laparoscopic surgery
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Sen S, Ozmert G, Boran N, et al. Comparison of single-breath vital capacity rapid inhalation with sevoflurane 5% and propofol induction on QT interval and haemodynamics for laparoscopic surgery. Eur J Anaesthesiol 2004; 21:543-546.
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Eur J Anaesthesiol
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Sen, S.1
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Boran, N.3
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Mechanism of QT interval prolongation induced by sevoflurane in guinea-pig ventricular myocyte
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Yamada M, Hatakeyama N, Shibuya N, et al. Mechanism of QT interval prolongation induced by sevoflurane in guinea-pig ventricular myocyte. Masui 2O03; 52:482-488.
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Yamada, M.1
Hatakeyama, N.2
Shibuya, N.3
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26
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Sustained prolongation of the QTc interval after anesthesia with sevoflurane in infants during the first 6 months of life
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Loeckinger A, Kleinsasser A, Maier S, et al. Sustained prolongation of the QTc interval after anesthesia with sevoflurane in infants during the first 6 months of life. Anesthesiology 2003; 98:639-642.
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Anesthesiology
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Loeckinger, A.1
Kleinsasser, A.2
Maier, S.3
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27
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QT prolongation and torsades de pointes in patients infected with human immunodeficiency virus and treated with methadone
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Gil M, Sala M, Anguera I, et al. QT prolongation and torsades de pointes in patients infected with human immunodeficiency virus and treated with methadone. Am J Cardiol 2003; 92:995-997.
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Am J Cardiol
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Gil, M.1
Sala, M.2
Anguera, I.3
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Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3
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Milberg P, Reinsch N, Wasmer K, et al. Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3. Cardiovasc Res 2005; 65:397-404.
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Cardiovasc Res
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Milberg, P.1
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Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers
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Priori SG, Napolitano C, Schwartz PJ, et al. Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA 2004; 292:1341-1344.
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Priori, S.G.1
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Electrical remodeling and arrhythmias in long-QT syndrome: Lessons from genetic models in mice
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Koren G. Electrical remodeling and arrhythmias in long-QT syndrome: lessons from genetic models in mice. Ann Med 2004; 36(Suppl. 1):22-27.
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Family and population strategies for screening and counselling of inherited cardiac arrhythmias
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van Langen IM, Hofman N, Tan HL, Wilde AA. Family and population strategies for screening and counselling of inherited cardiac arrhythmias. Ann Med 2004; 36(Suppl. 1):116-124. The authors examine new strategies for screening and for the counselling of inherited cardiac arrhythmias.
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Ann Med
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Van Langen, I.M.1
Hofman, N.2
Tan, H.L.3
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A comparison of commonly used QT correction formulae: The effect of heart rate on the QTc of normal ECGs
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Luo S, Michler K, Johnston P, Macfarlane PW. A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs. J Electrocardiol 2004; 37(Suppl. I):81 -90. The authors compare four commonly used QT correction formulae and recommend the Hodges formula be used to replace the popular Bazett's formula for QTc correction.
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J Electrocardiol
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Luo, S.1
Michler, K.2
Johnston, P.3
Macfarlane, P.W.4
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