In vitro anticancer activity of cyanidin-3-O-β-glucopyranoside: Effects on transformed and non-transformed T lymphocytes

Anticancer Research

Volumn 25, Issue 4, 2005, Pages 2837-2840

  Fimognari, Carmela ^a   Berti, Fausto ^a   Nüsse, Michael ^b   Cantelli Forti, Giorgio ^a   Hrelia, Patrizia ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Anthocyanins; Apoptosis; Chemoprevention; Genotoxicity; Lymphocytes

Indexed keywords

ANTHOCYANIN; CYANIDIN 3 O BETA GLUCOPYRANOSIDE; MYC PROTEIN; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; FLOW CYTOMETRY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICRONUCLEUS TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANTHOCYANINS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLUCOSIDES; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; PHYTOHEMAGGLUTININS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 22944492416     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Nowell PC: Mechanisms of tumor progression. Cancer Res 46: 2203-2207, 1986.
2. Pilot HC and Dragan YP: The multistage nature of chemically induced hepatocarcinogenesis in the rat. Drug Metab Rev 26: 209-220, 1994.
3. Hertog MGL, Hollman PCH, Katan MB and Kromout D: Intake of potentially anticarcinogenic flavonoids and their determinants in adults in Netherlands. Nutr Cancer 20: 21-29, 1993.
4. Galvano F, La Fauci L, Lazzarino G, Fogliano V, Ritieni A, Cappellano S, Battistini NC, Gavazzi B and Galvano G: Cyanidins: metabolism and biological properties. J Nutr Biochem 15: 2-11, 2004.
5. Amorini AM, Fazzina G, Lazzarino G, Gavazzi B, Di Pierro D, Cantucci R, Sinibaldi F, Galvano F and Galvano G: Activity and mechanism of the antioxidant properties of cyanidin-3-O-β-glucopyranoside. Free Radic Res 35: 953-966, 2001.
6. Lee HS: Characterization of major anthocyanins and the color of red-fleshed Budd Blood orange (Citrus sinensis). J Agric Food Chem 50: 1243-1246, 2002.
7. Serafino A, Sinibaldi-Vallebona P, Lazzarino G, Gavazzi B, Rasi G, Pierimarchi P, Andreola F, Moroni G, Galvano G, Galvano F and Garaci E: Differentiation of human melanoma cells induced by cyanidin-3-O-β- glucopyranoside. FASEB J 18: 1940-1942, 2004.
8. Fenech M and Morley AA: Measurement of micronuclei in lymphocytes. Mutat Res 147: 29-36, 1985.
9. Fenech M: The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285: 35-44, 1993.
10. Van Blitterswijk WJ: Membrane fluidity in normal and malignant lymphoid cells. Membr Fluid Biol 3: 85-159, 1985.
11. Youdim KA, Martin A and Joseph JA: Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 29: 51-60, 2000.
12. Prives C and Hall PA: The p53 pathway. J Pathol 187: 112-126, 1999.
13. Lambert JD, Hong J, Yang GY, Liao J and Yang CS: Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr 81: 284S-291S, 2005.
14. Youdim KA, Shukitt-Hale B, MacKinnon S, Kalt W and Joseph JA: Polyphenolics enhance red blood cell resistance to oxidative stress: in vitro and in vivo. Biochim Biophys Acta-Gen Subj 1523: 117-122, 2000.
15. Tsuda T, Horio F and Osawa T: Absorption and metabolism of cyanidin 3-O-β-D-glucoside in rats. FEBS Lett 449: 179-182, 1999.
16. Netzel M, Strass G, Janssen M, Bitsch I and Bitsch R: Bioactive anthocyanins detected in human urine after ingestion of blackcurrant juice. J Environ Pathol Toxicol Oncol 20: 89-95, 2001.
17. Miyazawa T, Nakagawa K, Kudo M, Muraishi K and Someya K: Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3, 5-diglucoside, into rats and humans. J Agric Food Chem 47: 1083-1091, 1999.