Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids

Antiviral Therapy

Volumn 10, Issue 2, 2005, Pages 263-275

  Ward, Sarah E ^a   Loutfy, Mona R ^b   Blatt, Lawrence M ^c   Siminovitch, Katharine A ^a   Chen, Jiabing ^a   Hinek, Anna ^a   Wolff, Bryan ^b   Pham, Dieu H ^b   Deif, Hassan ^b   LaMere, Elizabeth A ^b   Kain, Kevin C ^a   Forcas, Gabriella A ^a   Ferguson, Patti ^b   Latchford, Mary ^b   Levy, Gary ^a   Fung, Liasum ^a   Dennis, James W ^a   Lai, Enoch K Y ^b   Fish, Eleanor N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NORTH YORK GENERAL HOSPITAL   (Canada)

^c Intermune Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHEMOKINE; CONSENSUS INTERFERON; CORTICOSTEROID; CREATINE KINASE; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; MONOCYTE CHEMOTACTIC PROTEIN 1; PREDNISONE; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALPHA CHEMOKINE; ANTIVIRUS AGENT; BETA CHEMOKINE; CCL5 PROTEIN, HUMAN; CXC CHEMOKINE IP 10; CXC CHEMOKINE IP-10; GLUCOCORTICOID; INTERFERON ALFACON-1; RECOMBINANT INTERFERON;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ARTIFICIAL VENTILATION; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ASTHMA; BODY TEMPERATURE; CANADA; CLINICAL ARTICLE; CLINICAL FEATURE; COMORBIDITY; CREATINE KINASE BLOOD LEVEL; CYTOKINE RELEASE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN TISSUE; HYPERTENSION; LACTATE DEHYDROGENASE BLOOD LEVEL; LYMPHOCYTE COUNT; MALE; MITRAL VALVE PROLAPSE; OXYGEN SATURATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; THORAX RADIOGRAPHY; VIRUS LOAD; BLOOD; COHORT ANALYSIS; COMPARATIVE STUDY; DISEASE COURSE; DRUG COMBINATION; IMMUNOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOLOGY; TIME;

ADMINISTRATION, ORAL; ADRENAL CORTEX HORMONES; ADULT; ANTIVIRAL AGENTS; CHEMOKINES, CC; CHEMOKINES, CXC; COHORT STUDIES; CYTOKINES; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; HUMANS; INJECTIONS, INTRAVENOUS; INTERFERON TYPE I, RECOMBINANT; INTERFERON TYPE II; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PREDNISONE; SEVERE ACUTE RESPIRATORY SYNDROME; TIME FACTORS;

EID: 22844447271     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Tsang KW, Ho PL, Ooi GC, Yee WK, Wang T, Chan-Yeung M, Lam WK, Seto WH, Yam LY, Cheung TM, Wong PC, Lam B, Ip MS, Chan J, Yuen KY & Lai KN. A cluster of cases of severe acute respiratory syndrome in Hong Kong. New England Journal of Medicine 2003; 348:1977-1985.
2. World Health Organization Press Release. WHO issues a global alert about cases of atypical pneumonia. www.who.int/mediacentre/news/releases/2003/pr22/en/ 12 March 2003.
3. Goodman RB, Pugin J, Lee JS & Matthay MA. Cytokine-mediated inflammation in acute lung injury. Cytokine & Growth Factor Reviews 2003; 14:523-535.
4. Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Backer S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H & Doerr HW. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. New England Journal of Medicine 2003; 348:1967-1976.
5. Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ & Anderson LJ; SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. New England Journal of Medicine 2003; 348:1953-1966.
6. Kuiken T, Fouchier RA, Schutten M, Rimmelzwaan GF, van Amerongen G, van Riel D, Laman JD, de Jong T, van Doornum G, Lim W, Ling AE, Chan PK, Tam JS, Zambon MC, Gopal R, Drosten C, van der Werf S, Escriou N, Manuguerra JC, Stohr K, Peiris JS & Osterhaus AD. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003; 362:263-270.
7. Peiris JS. Severe acute respiratory syndrome (SARS). Journal of Clinical Virology 2003; 28:245-247.
8. Li L, Wo J, Shao J, Zhu H, Wu N, Li M, Yao H, Hu M & Dennin RH. SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients. Journal of Clinical Virology 2003; 28:239-244.
9. Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK OC Yuen KY; SARS study group. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361:1319-1325.
10. Peiris JS, Chu CM, Cheng VC, Chan KS, Hung IF, Poon LL, Law KI, Tang BS, Hon TY, Chan CS, Chan KH, Ng JS, Zheng BJ, Ng WL, Lai RW, Guan Y & Yuen KY; HKU/UCH SARS Study Group. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 2003; 361:1767-1772.
11. Poutanen SM, Low DE, Henry B, Finkelstein S, Rose D, Green K, Tellier R, Draker R, Adachi D, Ayers M, Chan AK, Skowronski DM, Salit I, Simor AE, Slutsky AS, Doyle PW, Krajden M, Petric M, Brunham RC & McGeer AJ; National Microbiology Laboratory, Canada; Canadian Severe Acute Respiratory Syndrome Study Team. Identification of severe acute respiratory syndrome in Canada. New England Journal of Medicine 2003; 348:1995-2005.
12. Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC, Chung S & Sung JJ. A major outbreak of severe acute respiratory syndrome in Hong Kong. New England Journal of Medicine 2003; 348:1986-1994.
13. Beijing Group of National Research Project for SARS. Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome. Chinese Medical Journal 2003; 116:1283-1287.
14. Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY & Peiris JS. Lung pathology of fatal severe acute respiratory syndrome. Lancet 2003; 361:1773-1778.
15. World Health Organization Press Release. Case definitions for surveillance of Severe Acute Respiratory Syndrome (SARS). www.who.int/csr/sars/ casedefinition/en/ Revised 1 May 2003.
16. Loutfy MR, Blatt LM, Siminovitch KA, Ward S, Wolff B, Lho H, Pham DH, Deif H, LaMere EA, Chang M, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Dennis JW, Lai EK & Fish EN. Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study. Journal of the American Medical Association 2003; 290:3222-3228.
17. Headley AS, Tolley E & Meduri GU. Infections and the inflammatory response in acute respiratory distress syndrome. Chest 1997; 111:1306-1321.
18. Krishnan S, Craven M, Welliver RC, Ahmad N & Halonen M. Differences in participation of innate and adaptive immunity to respiratory syncytial virus in adults and neonates. Journal of Infectious Diseases 2003; 188:433-439.
19. Bachert C, van Kempen MJ, Hopken K, Holtappels G & Wagenmann M. Elevated levels of myeloperoxidase, proinflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections. European Archives of Oto-rhino-laryngology 2001; 258:406-412.
20. Welliver RC. Respiratory syncytial virus and other respiratory viruses. Pediatric Infectious Disease Journal 2003; 22(Suppl 2):S6-10; discussion S10-12.
21. Hayden FG, Fritz R, Lobo MC, Alvord W, Strober W & Straus SE. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. Journal of Clinical Investigation 1998; 101:643-649.
22. Van Reeth K. Cytokines in the pathogenesis of influenza. Veterinary Microbiology 2000; 74:109-116.
23. Kajon AE, Gigliotti AP & Harrod KS. Acute inflammatory response and remodeling of airway epithelium after subspecies B1 human adenovirus infection of the mouse lower respiratory tract. Journal of Medical Virology 2003; 71:233-244.
24. Miller AL, Bowlin TL & Lukacs NW. Respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo. Journal of Infectious Diseases 2004; 189:1419-1430.
25. Jafri HS, Chavez-Bueno S, Mejias A, Gomez AM, Rios AM, Nassi SS, Yusuf M, Kapur P, Hardy RD, Hatfield J, Rogers BB, Krisher K & Ramilo O. Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice. Journal of Infectious Diseases 2004; 189:1856-1865.
26. Ng PC, Lam CW, Li AM, Wong CK, Cheng FW, Leung TF, Hon EK, Chan IH, Li CK, Fung KS & Fok TF. Inflammatory cytokine profile in children with severe acute respiratory syndrome. Pediatrics 2004; 113(1 Pt 1):e7-14.
27. Zhang Y, Li J, Zhan Y, Wu L, Yu X, Zhang W, Ye L, Xu S, Sun R, Wang Y & Lou J. Analysis of serum cytokines in patients with severe acute respiratory syndrome. Infection & Immunity 2004; 72:4410-4415.
28. Wong T, Majchrzak B, Bogoch E, Keystone EC & Fish EN. Therapeutic implications for interferon-alpha in arthritis: a pilot study. Journal of Rheumatology 2003; 30:934-940.
29. Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH, Lit LC, Hui DS, Chan MH, Chung SS & Sung JJ. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clinical & Experimental Immunology 2004; 136:95-103.
30. Vlahakis NE, Schroeder MA, Limper AH, Hubmayr RD. Stretch induces cytokine release by alveolar epithelial cells in vitro. American Journal of Physiology 1999; 277(1 Pt 1):L167-173.
31. Hsueh PR, Hsiao CH, Yeh SH, Wang WK, Chen PJ, Wang JT, Chang SC, Kao CL, Yang PC; SARS Research Group of National Taiwan University College of Medicine and National Taiwan University Hospital. Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan. Emerging Infectious Diseases 2003; 9:1163-1167.