Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 16, 2005, Pages 3732-3736

  Cui, Yong Mei ^a   Huang, Qing Qing ^a   Xu, Jie ^a   Chen, Ling Ling ^a   Li, Jing Ya ^a   Ye, Qi Zhuang ^a,b   Li, Jia ^a   Nan, Fa Jun ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; METHIONYL AMINOPEPTIDASE; PYRIDINE; THIAZOLE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINOPEPTIDASES; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; MOLECULAR STRUCTURE; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOAMIDES;

EID: 22844443265     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.055     Document Type: Article

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