Intercalation into the DNA double helix and in vivo biological activity of water-soluble planar [Pt(diimine)(N,N-dihydroxyethyl-N′-benzoylthioureato) ]+Cl- complexes: A study of their thermal stability, their CD spectra and their gel mobility

Archives of Biochemistry and Biophysics

Volumn 440, Issue 1, 2005, Pages 28-37

  Wu, Yu Shan ^a   Koch, Klaus R ^b   Abratt, Valerie R ^c   Klump, Horst H ^c  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

DNA; Intercalation; Planar platinum complexes; Water soluble

Indexed keywords

[(1,10 PHENANTHROLINE) N,N BIS(2 HYDROXYETHYL) N' BENZOYLTHIOUREATOPLATINUM]CHLORIDE; [(2,2' BIPYRIDYL) N,N BIS(2 HYDROXYETHYL) N' BENZOYLTHIOUREATOPLATINUM] CHLORIDE; [(4,4' DI TERT BUTYL 2,2' BIPYRIDYL) N,N BIS(2 HYDROXYETHYL) N' BENZYLTHIOUREATOPLATINUM]CHLORIDE; [(4,4' DIMETHYL 2,2' BIPYRIDYL) N,N BIS(2 HYDROXYETHYL) N' BENZOYLTHIOUREATOPLATINUM]CHLORIDE; BACTERIAL DNA; DNA; ETHIDIUM BROMIDE; PLATINUM COMPLEX; POLYNUCLEOTIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CATTLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA DENATURATION; DNA HELIX; DRUG ACTIVITY; DRUG DNA INTERACTION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; ESCHERICHIA COLI; EXCISION REPAIR; MELTING POINT; NONHUMAN; PRIORITY JOURNAL; SPECTROSCOPY; STOICHIOMETRY; THERMOSTABILITY; THYMUS;

ANIMALS; BINDING SITES; CIRCULAR DICHROISM; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ESCHERICHIA COLI; INTERCALATING AGENTS; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; ORGANOMETALLIC COMPOUNDS; PLATINUM; POLY DA-DT; SOLUBILITY; STEREOISOMERISM; TEMPERATURE; TIME FACTORS; WATER;

ESCHERICHIA COLI;

EID: 22744459783     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2005.05.022     Document Type: Article

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