Roles of leptin and ghrelin during the perinatal period

Clinical Pediatric Endocrinology

Volumn 12, Issue 2, 2003, Pages 57-65

  Yokota, Ichiro ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Ghrelin; Leptin; Perinatal period

Indexed keywords

GHRELIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; SOMATOMEDIN C;

ADIPOCYTE; BIRTH WEIGHT; BODY MASS; BODY WEIGHT; BRAIN; CORRELATION ANALYSIS; ENERGY BALANCE; ENERGY TRANSFER; HORMONE BLOOD LEVEL; HUMAN; NEWBORN PERIOD; NONHUMAN; OBESITY; PERINATAL PERIOD; PLACENTA; PLACENTA WEIGHT; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; THERMOGENESIS; UMBILICAL CORD BLOOD;

EID: 22744456266     PISSN: 09185739     EISSN: None     Source Type: Journal    
DOI: 10.1297/cpe.12.57     Document Type: Review

References (37)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the ob gene. Science 1995;269:543-6.
3. Campfield LA, Smith F, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-9.
4. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60.
5. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-98.
6. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000;141:4255-61.
7. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.
8. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002;87:240-4.
9. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med 1997;3:1029-33.
10. Gualillo O, Caminos J, Blanco M, Garcia-Caballero T, Kojima M, Kangawa K, et al. Ghrelin, a novel placental-derived hormone. Endocrinology 2001;142:788-94.
11. Matsuda J, Yokota I, Iida M, Murakami T, Naito E, Ito M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab 1997;82:1642-4.
12. Matsuda J, Yokota I, Iida M, Murakami T, Yamada M, Saijo T, et al. Dynamic changes in serum leptin concentrations during the fetal and neonatal periods. Pediatr Res 1999;45:71-5.
13. Matsuda J, Yokota I, Tsuruo Y, Murakami T, Ishimura K, Shima K, et al. Developmental changes in long-form leptin receptor expression and localization in rat brain. Endocrinology 1999;140:5233-8.
14. Hassink SG, de Lancey E, Sheslow DV, Smithkirwin SM, O'Connor DM, Considine RV, et al. Placental leptin: An important new growth factor in intrauterine and neonatal development? Pediatrics 1997;100:E11-6.
15. Schubring C, Kiess W, Englaro P, Rascher W, Dotsch J, Hanitsch S, et al. Level of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab 1997;82:1480-3.
16. Kitamura S, Yokota I, Hosoda H, Kotani Y, Matsuda J, Naito E, et al. Ghrelin concentration in cord and neonatal blood-Relation to fetal growth and energy balance-J Clin Endocrinol Metab 2003, in press.
17. Katayama M, Nogami H, Nishiyama J, Kawase T, Kawamura K. Developmentally and regionally regulated expression of growth hormone secretagogue receptor mRNA in rat brain and pituitary gland. Neuroendocrinology 2000;72:333-40.
18. Iida M, Murakami T, Yamada M, Sei M, Kuwajima M, Mizuno A, et al. Hyperleptinemia in chronic renal failure. Horm Metab Res 1997;28:724-7.
19. Lepercq J, Challier JC, Guerre-Millo M, Cauzac M, Vidal H, Hauguel-de Mouzon S. Prenatal leptin production: evidence that fetal adipose tissue produces leptin. J Clin Endocrinol Metab 2001;86:2409-13.
20. Behre HM, Simoni M, Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin Endocrinol 1997;47:237-40.
21. Shimizu H, Shimomura Y, Nakanishi Y, Futawatari T, Ohtani K, Sato N, et al. Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 1997;154:285-92.
22. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos FE, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-2.
23. Kolaczynski JW, Ohannesian JP, Considine RV, Marco CC, Caro JF. Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metab 1996;81:4162-5.
24. Dessolin S, Schalling M, Champigny O, Lonnqvist F, Ailhaud G, Dani C, et al. Leptin gene is expressed in rat brown adipose tissue at birth. FASEB J 1997;11:382-7.
25. Buchberger P, Schmidt I. Is the onset of obesity in suckling fa/fa rats linked to a potentially larger milk intake? Am J Physiol 1996;271:472-6.
26. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19:155-7.
27. Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S. Frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998;20:111-2.
28. Rayner DV, Dalgliesh GD, Duncan JS, Hardie LJ, Hoggard N, Trayhurn P. Postnatal development of the ob gene system: elevated leptin levels in suckling fa/fa rats. Am J Physiol 1997;273:446-50
29. Stehling O, Doring H, Ertl J, Preibisch G, Schmidt I. Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. Am J Physiol 1996;271:1770-4.
30. Mostyn A, Bispham J, Pearce S, Evens Y, Raver N, Keisler DH, et al. Differential effects of leptin on thermoregulation and uncoupling protein abundance in the neonatal lamb. FASEB J 2002;16:1438-40.
31. Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000;279:909-13.
32. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85:4908-11.
33. Lee HM, Wang G, Englander EW, Kojima M, Greeley GH Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002;143:185-90.
34. Hayashida T, Nakahara K, Mondal MS, Date Y, Nakazato M, Kojima M, et al. Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 2002;173:239-45
35. Lea RG, Howe D, Hannah LT, Bonneau O, Hunter L, Hoggard N. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod 2000;6:763-9.
36. Rindi G, Necchi V, Savio A, Torsello A, Zoli M, Locatelli V, et al. Characterization of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol 2002;117:511-9.
37. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A, Papotti M. Ghrelin expression in fetal, infant, and adult human lung. J Histochem Cytochem 2002;50:1013-21.