Beware of cells bearing gifts: Cell replacement therapy and arrhythmic risk

Circulation Research

Volumn 97, Issue 2, 2005, Pages 99-101

  Dudley, Samuel C ^a,b,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Arrhythmia; Electrophysiology; Genetic engineering; Regenerative medicine; Stem cells

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ARRHYTHMOGENESIS; EDITORIAL; EXCITATION CONTRACTION COUPLING; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART FAILURE; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS;

ARRHYTHMIA; HEART TRANSPLANTATION; HUMANS; MUSCLE, SKELETAL; MYOBLASTS;

EID: 22744445980     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.00000175827.99824.7f     Document Type: Editorial

References (31)

1. Dimmeler S, Zeiher AM. Wanted! The best cell for cardiac regeneration. J Am Coll Cardiol. 2004;44:464-466.
2. Menasche P. Skeletal myoblast transplantation for cardiac repair. Expert Rev Cardiovasc Ther. 2004;2:21-28.
3. Melo LG, Pachori AS, Kong D, Gnecchi M, Wang K, Pratt RE, Dzau VJ. Gene and cell-based therapies for heart disease. FASEB J. 2004;18: 648-663.
4. Kehat I, Gepstein L. Human embryonic stem cells for myocardial regeneration. Heart Fail Rev. 2003;8:229-236.
5. Lee MS, Makkar RR. Stem-cell transplantation in myocardial infarction: a status report. Ann Intern Med. 2004;140:729-737.
6. Agbulut O, Vandervelde S, Al Attar N, Larghero J, Ghostine S, Leobon B, Robidel E, Borsani P, Le Lorc'h M, Bissery A, Chomienne C, Bruneval P, Marolleau JP, Vilquin JT, Hagege A, Samuel JL, Menasche P. Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium. J Am Coll Cardiol. 2004;44:458-463.
7. Zhang YM, Hartzell C, Narlow M, Dudley SC Jr. Stem cell-derived cardiomyocytes demonstrate arrhythmic potential. Circulation. 2002;106: 1294-1299.
8. He JQ, Ma Y, Lee Y, Thomson JA, Kamp TJ. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res. 2003;93:32-39.
9. Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den Brink S, Hassink R, van der Heyden M, Opthof T, Pera M, de la Riviere AB, Passier R, Tertoolen L. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation. 2003;107:2733-2740.
10. Igelmund P, Fleischmann BK, Fischer IR, Soest J, Gryshchenko O, Bahm-Pirger MM, Sauer H, Liu Q, Hescheker J. Action potential propagation failures in long-term recordings from embryonic stem cell-derived cardiomyocytes in tissue culture. Pflügers Arch. 1999;437: 669-679.
11. Banach K, Halbach MD, Hu P, Hescheker J, Egert U. Development of electrical activity in cardiac myocyte aggregates derived from mouse embryonic stem cells. Am J Physiol. 2003;284:H2114-H2123.
12. Kehat I, Gepstein A, Spira A, Itshovitz-Eidor J, Gepstein L. High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ Res. 2002;91:659-661.
13. Soliman AM, Taylor DA, Thompson RB, Morimoto Y, McMichael M, Crater S, Krucoff MW. Assessment of electrical instability after autologous myoblast transplantation in a rabbit infarct model. Circulation. 108[17], IV-547-IV-548. 10-28-2003.
14. Sherman W, He K-L, Yi G-H, Zhou H, Gu A, Becker EM, Zhang G-P, Harvey J, Kao R, Lee M, Wang J, Haimes H, Burkhoff D. Ventricular arrhythmias following autologous skeletal myoblast implantation. J Am Coll Cardiol. 2003;41:176A.
15. Menasche P, Hagege AA, Vilquin JT, Desnos M, Abergel E, Pouzet B, Bel A, Sarateanu S, Scorsin M, Schwartz K, Bruneval P, Benbunan M, Marolleau JP, Duboc D. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol. 2003;41:1078-1083.
16. Menasche P, Hagege AA, Scorsin M, Pouzet B, Desnos M, Duboc D, Schwartz K, Vilquin JT, Marolleau JP. Myoblast transplantation for heart failure. Lancet. 2001;357:279-280.
17. Smits PC, van Geuns RJ, Poldermans D, Bountioukos M, Onderwater EE, Lee CH, Maat AP, Serruys PW. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol. 2003;42:2063-2069.
18. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002;106:1913-1918.
19. Assmus B, Schachinger V, Teupe C, Britten M, Lehmann R, Dobert N, Grunwald F, Aicher A, Urbich C, Martin H, Hoelzer D, Dimmeler S, Zeiher AM. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation. 2002;106:3009-3017.
20. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schumichen C, Nienaber CA, Freund M, Steinhoff G. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet. 2003;361:45-46.
21. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, Rossi MI, Carvalho AC, Dutra HS, Dohmann HJ, Silva GV, Belem L, Vivacqua R, Rangel FO, Esporcatte R, Geng YJ, Vaughn WK, Assad JA, Mesquita ET, Willerson JT. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation. 2003;107:2294-2302.
22. Fuchs S, Satler LF, Kornowski R, Okubagzi P, Weisz G, Baffour R, Waksman R, Weissman NJ, Cerqueira M, Leon MB, Epstein SE. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study. J Am Coll Cardiol. 2003;41:1721-1724.
23. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003;361:47-49.
24. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplanation. Circ Res. 2005;97:159-167.
25. Suzuki K, Brand NJ, Allen S, Khan MA, Farrell AO, Murtuza B, Oakley RE, Yacoub MH. Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. J Thorac Cardiovasc Surg. 2001;122:759-766.
26. Chedrawy EG, Wang JS, Nguyen DM, Shum-Tim D, Chiu RC. Incorporation and integration of implanted myogenic and stem cells into native myocardial fibers: anatomic basis for functional improvements. J Thorac Cardiovasc Surg. 2002;124:584-590.
27. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. 2003;9:1195-1201.
28. Murayama T, Asahara T. Bone marrow-derived endothelial progenitor cells for vascular regeneration. Curr Opin Mol Ther. 2002;4:395-402.
29. Min JY, Yang Y, Sullivan MF, Ke Q, Converso KL, Chen Y, Morgan JP, Xiao YF. Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells. J Thorac Cardiovasc Surg. 2003;125:361-369.
30. Leor J, Aboulafia-Etzion S, Dar A, Shapiro L, Barbash IM, Battler A, Granot Y, Cohen S. Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium? Circulation. 2000;102:III56-III61.
31. Zimmermann WH, Schneiderbanger K, Schubert P, Didic M, Munzel F, Heubach JF, Kostin S, Neuhuber WL, Eschanhagen T. Tissue engineering of a differentiated cardiac muscle construct. Circ Res. 2002;90:223-230.