7 Genetic Methods in Borrelia and Other Spirochaetes

Methods in Microbiology

Volumn 29, Issue C, 1999, Pages 209-227

  Rosa, Patricia ^a   Stevenson, Brian ^a   Tilly, Kit ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 22644452600     PISSN: 05809517     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0580-9517(08)70118-1     Document Type: Article

References (111)

1. Abeles A.L., Snyder K.M., and Chattoraj D.K. P1 plasmid replication: replicon structure. J. Mol. Biol. 173 (1984) 307-324
2. Barbour A.G. Plasmid analysis of Borrelia burgdorferi, the Lyme disease agent. J. Clin. Microbiol. 26 (1988) 475-478
3. Barbour A.G. Linear DNA of Borrelia species and antigenic variation. Trends Microbiol. 1 (1993) 236-239
4. Barbour A.G., and Garon C.F. Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237 (1987) 409-411
5. Barbour A.G., and Hayes S.F. Biology of Borrelia species. Microbiol. Rev. 50 (1986) 381-400
6. Barbour A.G., Burman N., Carter C.J., Kitten T., and Bergstrom S. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition. Mol. Microbiol. 5 (1991) 489-493
7. Barbour A.G., Carter C.J., Bundoc V., and Hinnebusch J. The nucleotide sequence of a linear plasmid of Borrelia burgdorferi reveals similarities to those of circular plasmids of other prokaryotes. J. Bacteriol. 178 (1996) 6635-6639
8. Baril C., Richaud C., Baranton G., Saint, and Girons I. Linear chromosome of. Borrelia burgdorferi. Res. Microbiol. 140 (1989) 507-516
9. Burgdorfer W., Barbour A.G., Hayes S.F., Benach J.L., Grunwaldt E., and Davis J.P. Lyme disease - a tick-borne spirochetosis?. Science 216 (1982) 1317-1319
10. Casjens S., and Earnshaw W. DNA packaging by the double-stranded DNA bacteriophages. Cell 21 (1980) 319-331
11. Casjens S., and Huang W.M. Linear chromosomal physical and genetic map of Borrelia burgdorferi, the Lyme disease agent. Mol. Microbiol. 8 (1993) 967-980
12. Casjens S., Hatfull G., and Hendrix R. Evolution of dsDNA tailed-bacteriophage genomes. Semin. Virol. 3 (1992) 383-397
13. Casjens S., DeLange M., Ley III H.L., Rosa P., and Huang W.M. Linear chromosomes of Lyme disease agent spirochetes: genetic diversity and conservation of gene order. J. Bacteriol. 177 (1995) 2769-2780
14. Casjens S., Murphy M., DeLange M., Sampson L., van Vugt R., and Huang W.M. Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres. Mol. Microbiol. 26 (1997) 581-596
15. Casjens S., van Vugt R., Tilly K., Rosa P.A., and Stevenson B. Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes. J. Bacteriol. 179 (1997) 217-227
16. Caudry S., Klitorinos A., Gharbia S.E., Pssara N., Siboo R., Keng T., and Chan E.C.S. Distribution and characterization of plasmids in oral anaerobic spirochetes. Oral Microbiol. Immunol. 10 (1995) 8-12
17. Combs B.G., Hampson D.J., and Harders S.J. Typing of Australian isolates of Treponema hyodysenteriae by serology and by DNA restriction endonuclease analysis. Vet. Microbiol. 31 (1992) 273-285
18. Defosse D.L., Johnson R.C., Paster B.J., Dewhirst F.E., and Fraser G.J. Brevinema andersonii gen. nov., sp. nov., an infectious spirochete isolated from the short-tailed shrew (Blarina brevicauda) and the white-footed mouse (Peromyscus leucopus). Int. J. Syst. Bacteriol. 45 (1995) 78-84
19. Dew-Jager K., Yu W.-Q., and Huang W.M. The recA gene of. Borrelia burgdorferi. Gene 167 (1995) 137-140
20. Dunn J.J., Buchstein S.R., Butler L.-L., Fisenne S., Polin D.S., Lade B.N., and Luft B.J. Complete nucleotide sequence of a circular plasmid from the Lyme disease spirochete. Borrelia burgdorferi. J. Bacteriol. 176 (1994) 2706-2717
21. Dykhuizen D.E., Polin D.S., Dunn J., Wilske B., Preac-Mursic V., Dattwyler R.J., and Luft B.J. Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development. Proc. Natl. Acad. Sci. USA 90 (1993) 10163-10167
22. Ferdows M.S., and Barbour A.G. Megabase-sized linear DNA in the bacterium Borrelia burgdorferi, the Lyme disease agent. Proc. Natl. Acad. Sci. USA 86 (1989) 5969-5973
23. Ferdows M.S., Serwer P., Griess G.A., Norris S.J., and Barbour A.G. Conversion of a linear to a circular plasmid in the relapsing fever agent. Borrelia hermsii. J. Bacteriol. 178 (1996) 793-800
24. Fraser C.M., Casjens S., Wai Mun Huang Sutton G.G., Clayton R., Lathigra R., White O., Ketchum K.A., Dodson R., Hickey E.K., Gwinn M., Dougherty B., Tomb J.-F., Fleischmann R.D., Richardson D., Peterson J., Kerlavage A.R., Quackenbush J., Salzberg S., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J., Weidman J., Utterback T., Watthey L., McDonald L., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Roberts K., Hatch B., Smith H.O., and Venter J.C. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390 (1997) 580-586
25. Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R., Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H., Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B., Horst K., Roberts K., Sandusky M., Weidman J., Smith H.O., and Venter J.C. Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281 (1998) 375-378 387-388
26. Fukunaga M., Okada K.M.N., Konishi T., and Sato Y. Phylogenetic analysis of Borrelia species based on flagellin gene sequences and its application for molecular typing of Lyme disease borreliae. Int. J. Syst. Bacteriol. 46 (1996) 898-905
27. Gibbs C.P., Livey I., and Dorner F. The role of recombination in OspC variation in Lyme disease. Borrelia. Acta Dermatovenerologica Alpina, Pannonica et Adriatica 5 (1996) 179-183
28. Giladi M., Champion C.I., Haake D.A., Blanco D.R., Miller J.F., Miller J.N., and Lovett M.A. Use of the "blue halo" assay in the identification of genes encoding exported proteins with cleavable signal peptides: cloning of a Borrelia burgdorferi plasmid gene with a signal peptide. J. Bacteriol. 175 (1993) 4129-4136
29. Harris D.L., Glock R.D., Christensen C.R., and Kinyon J.M. Swine dysentery. I. Inoculation of pigs with Treponema hyodysenteriae (new species) and reproduction of the disease. Vet. Med. Small Anim. Clin. 67 (1972) 61-64
30. Hayes L.J., Wright D.J.M., and Archard L.C. Segmented arrangement of Borrelia duttonii DNA and location of variant surface antigen genes. J. Gen. Microbiol. 134 (1988) 1785-1793
31. Hayes S.F., Burgdorfer W., and Barbour A.G. Bacteriophage in the Ixodes dammini spirochete, etiological agent of Lyme disease. J. Bacteriol. 154 (1983) 1436-1439
32. Herrmann J.L., Baril C., Bellenger E., Perolat P., Baranton G., and Saint Girons I. Genome conservation in isolates of. Leptospira interrogans. J. Bacteriol. 173 (1991) 7582-7588
33. Hinnebusch J., and Barbour A.G. Linear- and circular-plasmid copy numbers in. Borrelia burgdorferi. J. Bacteriol. 174 (1992) 5251-5257
34. Hinnebusch J., and Tilly K. Linear plasmids and chromosomes in bacteria. Mol. Microbiol. 10 (1993) 917-922
35. Humphrey S.B., Stanton T.B., and Jensen N.S. Mitomycin C induction of bacteriophages from Serpulina hyodysenteriae and. Serpulina innocens. FEMS Microbiol. Lett. 134 (1995) 97-101
36. Humphrey S.B., Stanton T.B., Jensen N.S., and Zuerner R.L. Purification and characterization of VSH-1, a generalized transducing bacteriophage of. Serpulina hyodysenteriae. J. Bacteriol. 179 (1997) 323-329
37. Hyatt D.R., ter Huurne A.A.H.M., van der Zeijst B.A.M., and Joens L.A. Reduced virulence of Serpulina hyodysenteriae hemolysin-negative mutants in pigs and their potential to protect pigs against a challenge with a virulent strain. Infect. Immun. 62 (1994) 2244-2248
38. Hyde F.W., and Johnson R.C. Characterization of a circular plasmid from Borrelia burgdorferi, etiologic agent of Lyme disease. J. Clin. Microbiol. 26 (1988) 2203-2205
39. Ivic A., MacDougall J., Russell R.R.B., and Penn C.W. Isolation and characterization of a plasmid from. Treponema denticola. FEMS Microbiol. Lett. 78 (1991) 189-194
40. Jauris-Heipke S., Liegl G., Preac-Mursic V., Robler D., Schwab E., Soutschek E., Will G., and Wilske B. Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of. OspC. J. Clin. Microbiol. 33 (1995) 1860-1866
41. Johnson R.C. The spirochetes. Ann. Rev. Microbiol. 31 (1977) 89-106
42. Johnson R.C., Schmid G.P., Hyde F.W., Steigerwalt A.G., and Brenner D.J. Borrelia burgdorferi sp. nov.: etiologic agent of Lyme disease. Int. J. Syst. Bacteriol. 34 (1984) 496-497
43. Kataoka M., Li H., Arakawa S., and Kuramitsu H. Characterization of a methyl-accepting chemotaxis protein gene, dmcA, from the oral spirochete. Treponema denticola. Infect. Immun. 65 (1997) 4011-4016
44. Kennedy M.J., Rosey E.L., and Yancey Jr. R.L. Characterization of flaA and flaB- mutants of Serpulina hyodysenteriae: both flagellin subunits, FlaA and FlaB, are necessary for full motility and intestinal colonization. FEMS Microbiol. Lett. 153 (1997) 119-128
45. Kitten T., and Barbour A.G. The relapsing fever agent Borrelia hermsii has multiple copies of its chromosome and linear plasmids. Genetics 132 (1992) 311-324
46. Li H., and Kuramitsu H.K. Development of a gene transfer system in Treponema denticola by electroporation. Oral Microbiol. Immunol. 11 (1996) 161-165
47. Li H., Ruby J., Charon N., and Kuramitsu H. Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant. J. Bacteriol. 178 (1996) 3664-3667
48. Livey I., Gibbs C.P., Schuster R., and Dorner F. Evidence for lateral transfer and recombination in OspC variation in Lyme disease. Borrelia. Mol. Microbiol. 18 (1995) 257-269
49. MacDougall J., Margarita D., and Saint Girons I. Homology of a plasmid from the spirochete Treponema denticola with the single-stranded DNA plasmids. J. Bacteriol. 174 (1992) 2724-2728
50. Marconi R.T., Samuels D.S., and Garon C.F. Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes. J. Bacteriol. 175 (1993) 926-932
51. Marconi R.T., Casjens S., Munderloh U.G., and Samuels D.S. Analysis of linear plasmid dimers in Borrelia burgdorferi sensu lato isolates: implications concerning the potential mechanism of linear plasmid replication. J. Bacteriol. 178 (1996) 3357-3361
52. Masuda K., and Kawata T. Bacteriophage-like particles induced from the Reiter treponeme by mitomycin C. FEMS Microbiol. Lett. 6 (1979) 29-31
53. Maxwell A. The interaction between coumarin drugs and DNA gyrase. Mol. Microbiol. 9 (1993) 681-686
54. Meier J.T., Simon M.I., and Barbour A.G. Antigenic variation is associated with DNA rearrangements in a relapsing fever. Borrelia. Cell 41 (1985) 403-409
55. Motallebi-Veshareh M., Rouch D.A., and Thomas C.M. A family of ATPases involved in active partitioning of diverse bacterial plasmids. Mol. Microbiol. 4 (1990) 1455-1463
56. Munderloh U.G., Park Y.-J., Dioh J.M., Fallon A.M., and Kurtti T.J. Plasmid modifications in a tick-borne pathogen, Borrelia burgdorferi, cocultured with tick cells. Insect Mol. Biol. 1 (1993) 195-203
57. Neubert U., Schaller M., Januschke E., Stolz W., and Schmieger H. Bacteriophages induced by ciprofloxacin in a Borrelia burgdorferi skin isolate. Zentralbl. Bakteriol. 279 (1993) 307-315
58. Norton Hughes C.A., and Johnson R.C. Methylated DNA in Borrelia species. J. Bacteriol. 172 (1990) 6602-6604
59. Ogura T., and Hiraga S. Partition mechanism of F plasmid: two plasmid gene-encoded products and a cis-acting region are involved in partition. Cell 32 (1983) 351-360
60. Ojaimi C., Saint Davidson B.E., Girons I., and Old I.G. Conservation of gene arrangement and an unusual organization of rRNA genes in the linear chromosomes of the Lyme disease spirochaetes Borrelia burgdorferi, B. garinii and. B. afzelii. Microbiology 140 (1994) 2931-2940
61. Pacciarini M.L., Savio M.L., Tagliabue S., and Rossi C. Repetitive sequences cloned from Leptospira interrogans servovar hardjo genotype hardjoprajitno and their application to serovar identification. J. Clin. Microbiol. 30 (1992) 1243-1249
62. Pasta F., and Sicard M.A. Exclusion of long heterologous insertions and deletions from the pairing synapsis in pneumococcal transformation. Microbiology 142 (1996) 695-705
63. Paster B.J., Stackebrandt E., Hespell R.B., Hahn C.M., and Woese C.R. The phylogeny of the spirochetes. Syst. Appl. Microbiol. 5 (1984) 337-351
64. Paster B.J., Dewhirst F.E., Weisburg W.G., Tordoff L.A., Fraser G.J., Hespell R.B., Stanton T.B., Zablen L., Mandelco L., and Woese C.R. Phylogenetic analysis of the spirochetes. J. Bacteriol. 173 (1991) 6101-6109
65. Perng G.C., and LeFebvre R.B. Expression of antigens from chromosomal and linear plasmid DNA of. Borrelia coriaceae. Infect. Immun. 58 (1990) 1744-1748
66. Plasterk R.H.A., Simon M.I., and Barbour A.G. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium. Borrelia hermsii. Nature 318 (1985) 257-263
67. Porcella S.F., Popova T.G., Akins D.R., Li M., Radolf J.D., and Norgard M.V. Borrelia burgdorferi supercoiled plasmids encode multi-copy tandem open reading frames and a lipoprotein gene family. J. Bacteriol. 178 (1996) 3293-3307
68. Ralph D., and McClelland M. Phylogenetic evidence for horizontal transfer of an intervening sequence between species in a spirochete genus. J. Bacteriol. 176 (1994) 5982-5987
69. Ralph D., Que Q., Van Etten J.L., and McClelland M. Leptospira genomes are modified as 5′-GTAC. J. Bacteriol. 175 (1993) 3913-3915
70. Restrepo B.I., and Barbour A.G. Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes. Cell 78 (1994) 867-876
71. Ritchie A.E., Robinson I.M., Joens L.A., and Kinyon J.M. A bacteriophage for. Treponema hyodysenteriae. Veterin. Rec. 102 (1978) 34-35
72. E15. J. Biol. Chem. 240 (1965) 384-390
73. Rosa P.A., Schwan T., and Hogan D. Recombination between genes encoding major outer surface proteins A and B of. Borrelia burgdorferi. Mol. Microbiol. 6 (1992) 3031-3040
74. Rosa P., Samuels D.S., Hogan D., Stevenson B., Casjens S., and Tilly K. Directed insertion of a selectable marker into a circular plasmid of. Borrelia burgdorferi. J. Bacteriol. 178 (1996) 5946-5953
75. Rosey E.L., Kennedy M.J., Petrella D.K., Ulrich R.G., and Yancey Jr. R.J. Inactivation of Serpulina hyodysenteriae flaA1 and flaB1 periplasmic flagellar genes by electroporation-mediated allelic exchange. J. Bacteriol. 177 (1995) 5959-5970
76. Rosey E.L., Kennedy M.L., and Yancey Jr. R.J. Dual flaA1 flaB1 mutant of Serpulina hyodysenteriae expressing periplasmic flagella is severely attenuated in a murine model of swine dysentery. Infect. Immun. 64 (1996) 4154-4162
77. Sadziene A., Wilske B., Ferdows M.S., and Barbour A.G. The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect. Immun. 61 (1993) 2192-2195
78. Saint Girons I., Margarita D., Amouriaux P., and Baranton G. First isolation of bacteriophages for a spirochaete: potential genetic tools for. Leptospira. Res. Microbiol. 141 (1990) 1131-1138
79. Samuels D.S. Electrotransformation of the spirochete Borrelia burgdorferi. In: Nickoloff J.A. (Ed). Methods in Molecular Biology (1995), Humana Press, Totowa, New Jersey 253-259
80. Samuels D.S., and Garon C.F. Coumermycin A, inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent. Antimicrob. Agents Chemother. 37 (1993) 46-50
81. Samuels D.S., and Garon C.F. Oligonucleotide-mediated genetic transformation of. Borrelia burgdorferi. Microbiology 143 (1997) 519-522
82. Samuels D.S., Marconi R.T., and Garon C.F. Variation in the size of the ospA-containing linear plasmid, but not the linear chromosome, among three Borrelia species associated with Lyme disease. J. Gen. Microbiol. 139 (1993) 2445-2449
83. Samuels D.S., Mach K.E., and Garon C.F. Genetic transformation of the Lyme disease agent Borrelia burgdorferi with coumarin-resistant. GyrB. J. Bacteriol. 176 (1994) 6045-6049
84. 1-resistant Borrelia burgdorferi. J. Bacteriol. 176 (1994) 3072-3075
85. Schaller M., and Neubert U. Bacteriophages and ultrastructural alterations of Borrelia burgdorferi induced by ciprofloxacin. J. Spirochetal Tick-Borne Dis. 1 (1994) 37-40
86. Simpson W.J., Garon C.F., and Schwan T.G. Analysis of supercoiled circular plasmids in infectious and non-infectious. Borrelia burgdorferi. Microb. Pathogen. 8 (1990) 109-118
87. Sohaskey C.D., Arnold C., and Barbour A.G. Analysis of promoters in Borrelia burgdorferi by use of a transiently expressed reporter gene. J. Bacteriol. 179 (1997) 6837-6842
88. Stålhammar-Carlemalm M., Jenny E., Gern L., Aeschlimann A., and Meyer J. Plasmid analysis and restriction fragment length polymorphisms of chromosomal DNA allow a distinction between Borrelia burgdorferi strains. Zentralbl. Bakteriol. 274 (1990) 28-39
89. Stamm L.V., Greene S.R., Barnes N.Y., Bergen H.L., and Hardham J.M. Identification and characterization of a Treponema pallidum subsp. pallidum gene encoding a DNA adenine methyltransferase. FEMS Microbiol. Lett. 155 (1997) 115-119
90. Stanton T.B., Jensen N.S., Casey T.A., Tordoff L.A., Dewey F.E., and Paster B.J. Reclassification of Treponema hyodysenteriae and Treponema innocens in a new genus, Serpula gen. nov., as Serpula hyodysenteriae comb. nov. and Serpula innocens comb. nov. Int. J. Syst. Bacteriol. 41 (1991) 50-58
91. Steere A.C., Grodzicki R.L., Kornblatt A.N., Craft J.E., Barbour A.G., Burgdorfer W., Schmid G.P., Johnson E., and Malawista S.E. The spirochetal etiology of Lyme disease. N. Engl. J. Med. 308 (1983) 733-740
92. Stevenson B., and Barthold S.W. Expression and sequence of outer surface protein C among North American isolates of. Borrelia burgdorferi. FEMS Microbiol. Lett. 124 (1994) 367-372
93. Stevenson B., Tilly K., and Rosa P.A. A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. J. Bacteriol. 178 (1996) 3508-3516
94. Stevenson B., Casjens S., van Vugt R., Porcella S.F., Tilly K., Bono J.L., and Rosa P. Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids. J. Bacteriol. 179 (1997) 4285-4291
95. Stevenson B., Casjens S., and Rosa P. Evidence of past recombination events among the genes encoding the Erp antigens of. Borrelia burgdorferi. Microbiology 144 (1998) 1869-1879
96. Taylor K.A., Barbour A.G., and Thomas D.D. Pulsed-field gel electrophoretic analysis of leptospiral DNA. Infect. Immun. 59 (1991) 323-329
97. ter Huurne A.A.H.M., van Houten M., Muir S., Kusters J.G., van der Zeijst B.A.M., and Gaastra W. Inactivation of a Serpula (Treponema) hyodysenteriae hemolysin gene by homologous recombination: importance of this hemolysin in pathogenesis of S. hyodysenteriae in mice. FEMS Microbiol. Lett. 92 (1992) 109-114
98. Tilly K., Casjens S., Stevenson B., Bono J.L., Samuels D.S., Hogan D., and Rosa P. The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. Mol. Microbiol. 25 (1997) 361-373
99. Tilly K., Lubke L., and Rosa P. Characterization of circular plasmid dimers in. Borrelia burgdorferi. J. Bacteriol 180 (1998) 5676-5681
100. Turner A.K., and Sellwood R. Extracellular DNA from Serpulina hyodysenteriae consists of 6.5 kbp random fragments of chromosomal DNA. FEMS Microbiol. Lett. 150 (1997) 75-80
101. Van Eys G.J.J.M., Zaal J., Schoone G.J., and Terpstra W.J. DNA hybridization with hardjobovis-specific recombinant probes as a method for type discrimination of Leptospira interrogans serovar. Hardjo. J. Gen. Microbiol. 134 (1988) 567-574
102. Vinetz J.M. Leptospirosis. Curr. Opin. Infect. Dis. 10 (1997) 357-361
103. Watanabe E., Wachi M., Yamasaki M., and Nagai K. ATPase activity of SopA, a protein essential for active partitioning of F plasmid. Mol. Gen. Genet. 234 (1992) 346-352
104. Woese C.R. Bacterial evolution. Microbiol. Rev. 51 (1987) 221-271
105. Woodward M.J., and Sullivan G.J. Nucleotide sequence of a repetitive element isolated from Leptospira interrogans serovar hardjo type. Hardjo-bovis. J. Gen. Microbiol. 137 (1991) 1101-1109
106. Xu Y., and Johnson R.C. Analysis and comparison of plasmid profiles of Borrelia burgdorferi sensu lato strains. J. Clin. Microbiol. 33 (1995) 2679-2685
107. Zhang J.-R., Hardham J.M., Barbour A.G., and Norris S.J. Antrigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell 89 (1997) 1-20
108. Zückert W.R., and Meyer J. Circular and linear plasmids of Lyme disease spirochetes have extensive homology: characterization of a repeated DNA element. J. Bacteriol. 178 (1996) 2287-2298
109. Zuerner R.L. Nucleotide sequence analysis of IS1533 from Leptospira borg-petersenii: identification and expression of two IS-encoded proteins. Plasmid 31 (1994) 1-11
110. Zuerner R.L., and Bolin C.A. Repetitive sequence element cloned from Leptospira interrogans serovar hardjo type hardjo-bovis provides a sensitive diagnostic probe for bovine leptospirosis. J. Clin. Microbiol. 26 (1988) 2495-2500
111. Zuerner R.L., Herrmann J.L., and Saint Girons I. Comparison of genetic maps for two Leptospira interrogans serovars provides evidence for two chromosomes and intraspecies heterogeneity. J. Bacteriol. 175 (1993) 5445-5451