Albumin-insulin conjugate releasing insulin slowly under physiological conditions: A new concept for long-acting insulin

Bioconjugate Chemistry

Volumn 16, Issue 4, 2005, Pages 913-920

  Shechter, Yoram ^a   Mironchik, Marina ^a   Rubinraut, Sara ^a   Saul, Ayala ^a   Tsubery, Haim ^a   Fridkin, Mati ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CONTROLLED DRUG DELIVERY; GLUCOSE; MAMMALS; TARGETED DRUG DELIVERY;

AMINO GROUP; COVALENT LINKAGE; FLUORENES; HUMAN SERUM ALBUMINS; IN-VIVO; N-HYDROXYSUCCINIMIDE; PEPTIDE DRUGS; PHYSIOLOGICAL CONDITION; PROTEIN DRUGS; SIDE-CHAINS;

INSULIN;

9 FLUORENYLMETHYL CHLOROFORMATE; 9 HYDROXYMETHYL 2 (AMINO 3 MALEIMIDOPROPIONATE)FLUORENE N HYDROXYSUCCINIMIDE; AMINE; CYSTEINE; GLUCOSE; HUMAN SERUM ALBUMIN; INSULIN; INSULIN GLARGINE; LONG ACTING DRUG; MALEIMIDE DERIVATIVE; PROPIONIC ACID DERIVATIVE; REAGENT; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; ZINC ION;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONJUGATE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; COVALENT BOND; DIABETES MELLITUS; DOSE RESPONSE; DRUG CONJUGATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SOLUBILITY; HYDROLYSIS; MALE; MOUSE; NONHUMAN; RAT;

RODENTIA;

EID: 22644437189     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc050055w     Document Type: Article

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