Oestrogen-receptors (ER) are likely to be promiscuous: Wider role for oestrogens and mimics

Medical Hypotheses

Volumn 65, Issue 4, 2005, Pages 760-765

  Wiseman, Alan ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYESTRADIOL; 4 HYDROXYESTRADIOL; ANTINEOPLASTIC AGENT; AROMATIC HYDROCARBON; CHAPERONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2D6; DIOXIN; DNA; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ISOENZYME; ORAL CONTRACEPTIVE AGENT; OXIDOREDUCTASE; POLYCYCLIC AROMATIC HYDROCARBON; RECEPTOR; TAMOXIFEN; XENOBIOTIC AGENT;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOTRANSFORMATION; BRAIN TISSUE; BREAST; BREAST CANCER; COMPLEX FORMATION; ESTROGEN THERAPY; GENE; GENE EXPRESSION; GENE TARGETING; GENOME; HORMONE METABOLISM; HORMONE SUBSTITUTION; HUMAN; HYDROXYLATION; INJURY; LIVER; METABOLISM; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TARGET ORGAN; UTERUS;

ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CYTOCHROME P-450 ENZYME SYSTEM; CYTOPLASM; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROCARBONS, AROMATIC; LIVER; PROTEIN BINDING; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; UTERUS;

EID: 22544475596     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.04.019     Document Type: Article

References (25)

1. J.A. Robertson, Y. Farnell, L.S. Lindahl, and N.H. Ing Estradiol up-regulates receptor messenger ribonucleic acid in endometrial carcinoma (Ishikawa) cells by stabilising the message J Mol Endocrinol 29 2002 125 135
2. P.C. Kulakosky, M.A. McCarty, S.C. Jermgan, K.E. Risinger, and C.M. Klinge Response element sequence modulates estrogen receptor α and β affinity and activity J Mol Endocrinol 29 2002 137 152
3. H. Wiseman, P. Goldfarb, T. Ridgway, and A. Wiseman Biomolecular free radical toxicity: causes and prevention 2000 Wiley Chichester, UK
4. D.F.V. Lewis Guide to Cytochromes P450 structure and function 2001 Taylor & Francis London, UK
5. B. Halliwell, and J.M.C. Gutteridge Free radicals in biology and medicine 3rd ed. 1999 Clarendon Press Oxford
6. M.N. Altamirano, J.M. Blackburn, C. Aguayo, and A.R. Fersht Directed evolution of new catalytic activity using the α/β-barrel scaffold Nature 403 2000 617 622
7. A.M. Brzozwski, A.C.W. Pike, Z. Dauter, R.E. Hubbard, T. Bonn, and O. Engstrom Structure of the oestrogen receptor Nature 389 1997 753 758
8. T. Palmer Enzymes: biochemistry, biotechnology, clinical chemistry 2001 Horwood Publishing Chichester, UK
9. A. Wiseman Do unpredictable toxic side effects of drugs reflect their promiscuous binding energies? Trends Pharmacol Sci 24 2003 61 62
10. A. Wiseman Comparison of soluble and immobilised enzymes J Biol Educat 37 2003 99
11. E.J. Calabrese, and L.A. Baldwin Toxicology rethinks its central belief Nature 421 2003 691 692
12. D. Abele The radical life-giver Nature 420 2002 27
13. S.D. Conner, and S.L. Schmid Regulated portals of entry into the cell Nature 422 2003 37 44
14. A. Kumer A naturally occurring MTAI-variant sequesters oestrogen-receptor (α) in the cytoplasm Nature 418 2002 654 657
15. H.G. Dohiman Diminishing returns Nature 418 2003 591
16. L. Melton Oestrogen on the brain Chem Britain 39 2003 41 43
17. A. Wiseman, and L.F.J. Woods Can "real-lab" supersede "virtual-ligand" promises? Trends Pharmacol Sci 23 2002 261
18. A. Wiseman, D.F.V. Lewis, T.J. Ridgway, and H. Wiseman Cytochromes P-450 in food-processing: limitations of imitations J Chem Technol Biotechnol 75 2000 3 5
19. H. Wiseman Tamoxifen: molecular basis of use in cancer treatment and prevention 1994 Wiley Chichester, UK
20. T. Kushiro, E. Nambara, and P. McCourt The key to signalling Nature 422 2003 122
21. A. Johnson, and R. Darton Gender benders The Chemical Engineer 741 2003 37 39
22. E.C. Opara Oxidative stress, micronutrients, diabetes mellitus and its complications J Royal Soc Health 122 2002 28 34
23. A. Wiseman Targeted membrane-penetrating peptides: identify drug cargoes in silico? Drug Delivery Syst Sci 2 2003 114
24. B. Halliwell, and M. Whiteman Measuring reactive oxygen species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142 2004 231 255
25. A. Wiseman Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes Med Hypoth 64 4 2005 802 805