Neuroprotective and cardioprotective actions of an association of pyruvate, vitamin E and fatty acids

Arzneimittel-Forschung/Drug Research

Volumn 55, Issue 7, 2005, Pages 359-369

  Paquin, Joanne ^a   Aouffen, M'Hammed ^a   De Grandpré, Eric ^a   Nadeau, Réginald ^b   Langlois, Denis ^c   Mateescu, Mircea Alexandru ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^c Gestilab Inc   (Canada)

Author keywords

Antioxidant association, anti oxidant capacity, Langendorff heart perfusion; Fatty acids, antioxidant capacity, association with vitamin E and pyruvate; P19 embryonic stem cells; Pyruvate, antioxidant capacity, association with vitamin E and fatty acids

Indexed keywords

ALPHA TOCOPHEROL; FATTY ACID; FERROUS ION; HYDROGEN PEROXIDE; HYDROXYL RADICAL; PYRUVIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ASSAY; CELL MEMBRANE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG ACTIVITY; ELECTROLYSIS; EX VIVO STUDY; HEART INJURY; HEART LEFT VENTRICLE PRESSURE; HEART PERFUSION; HEART PROTECTION; HEART RATE; HEART VENTRICLE FIBRILLATION; IN VITRO STUDY; INCIDENCE; NERVE CELL CULTURE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT;

EID: 22544474155     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296873     Document Type: Article

References (51)

1. LeBel, C. P., Bondy, S. C., Oxygen Radicals: Common Mediators of Neurotoxicity. Neurotoxicol. Teratol. 13, 341 (1991)
2. Gutteridge, J. M., Hydroxyl Radicals, Iron, Oxidative Stress, and Neurodegeneration. Ann. N. Y. Acad. Sci. 738, 201 (1994)
3. Chan, P. H., Role of Oxidants in Ischemic Brain Damage. Stroke 27, 1124 (1996)
4. Cuzzocrea, S., Riley, D. P., Caputi, A. P. et al., Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury. Pharmacol. Rev. 53, 135 (2001)
5. Takemura, G., Onodera, T., Ashraf, M., Characterization of Exogenous Hydroxyl Radical Effects on Myocardial Function, Metabolism and Ultrastructure. J. Mol. Cell. Cardiol. 26, 441 (1994)
6. Hoeschen, R. J., Oxidative Stress and Cardiovascular Disease. Can. J. Cardiol. 13, 1021 (1997)
7. Chakraborti, T., Ghosh, S. K., Michael, J. R. et al., Targets of Oxidative Stress in Cardiovascular System. Mol. Cell. Biochem. 187, 1 (1998)
8. Maiese, K., From the Bench to the Bedside: The Molecular Management of Cerebral Ischemia. Clin. Neuropharmacol. 21, 1 (1998)
9. Pryor, W. A., Vitamin E and Heart Disease: Basic Science to Clinical Intervention Trials. Free Radic. Biol. Med. 28, 141 (2000)
10. Khalil, A., [Molecular Mechanisms of the Protective Effect of Vitamin E against Atherosclerosis]. Can. J. Physiol. Pharmacol. 80, 662 (2002)
11. Peuchen, S., Bolanos, J. P., Heales, S. J. et al., Inter-relationships between Astrocyte Function, Oxidative Stress and Antioxidant Status within the Central Nervous System. Prog. Neurobiol. 52, 261 (1997)
12. Halliwell, B., Antioxidant Defence Mechanisms: From the Beginning to the End (of the Beginning). Free Radic. Res. 31, 261 (1999)
13. Young, I. S., Tate, S., Lightbody, J.H. et al., The Effects of Desferrioxamine and Ascorbate on Oxidative Stress in the Streptozotocin Diabetic Rat. Free Radic. Biol. Med. 18, 833 (1995)
14. Boland, A., Delapierre, D., Mossay, D. et al., Propofol Protects Cultured Brain Cells from Iron Ion-Induced Death: Comparison with Trolox. Eur. J. Pharmacol. 404, 21 (2000)
15. Prasad, K. N., Hovland, A. R., Cole, W. C. et al., Multiple Antioxidants in the Prevention and Treatment of Alzheimer Disease: Analysis of Biologic Rationale. Clin. Neuropharmacol. 23, 2 (2000)
16. Gultekin, F., Delibas, N., Yasar, S. et al., In Vivo Changes in Antioxidant Systems and Protective Role of Melatonin and a Combination of Vitamin C and Vitamin E on Oxidative Damage in Erythrocytes Induced by Chlorpyrifos-Ethyl in Rats. Arch. Toxicol. 75, 88 (2001)
17. Martin, A., Cytoprotective Compositions Containing Pyruvate and Antioxidants. PCT US/93/00260, WO/93/16690
18. Martin, A., Cytoprotective Wound Healing Compositions and Methods for Preparing and Using the Same. US Patent 5,633,285
19. Bauer, G., O'Connell, S., Devereux, D. et al., Reversal of Doxorubicin-Impaired Wound Healing Using Triad Compound. Am. Surg. 60, 455 (1994)
20. Martin, A., The Use of Antioxidants in Healing. Dermatol. Surg. 22, 156 (1996)
21. Sheridan, J., Kern, E., Martin, A. et al., Evaluation of Antioxidant Healing Formulations in Topical Therapy of Experimental Cutaneous and Genital Herpes Simplex Virus Infections. Antiviral Res. 36, 157 (1997)
22. Gokhale, M. S., Lin, J. R., Yager, J. D., A Mixture of Antioxidants and Fatty Acids Improves the Viability of Cultured Rat Hepatocytes Untreated or Treated with Doxorubicin. Toxicology in Vitro 11, 753 (1997)
23. McBurney, M. W., P19 Embryonal Carcinoma Cells. Int. J. Dev. Biol. 37, 135 (1993)
24. Jeannotte, R., Paquin, J., Petit-Turcotte, C. et al., Convertase PC2 and the Neuroendocrine Polypeptide 7B2 Are Co-Induced and Processed During Neuronal Differentiation of P19 Embryonal Carcinoma Cells. DNA Cell Biol. 16, 1175 (1997)
25. Cadet, N., Paquin, J., Conversion and Storage of Somatostatin Are Established before Response to Secretagogue Stimuli in P19 Neurons. Brain Res. Dev. Brain Res. 120, 211 (2000)
26. Desagher, S., Glowinski, J., Premont, J., Astrocytes Protect Neurons from Hydrogen Peroxide Toxicity. J. Neurosci. 16, 2553 (1996)
27. Chahine, R., Mateescu, M. A., Roger, S. et al., Protective Effects of Ceruloplasmin against Electrolysis-Induced Oxygen Free Radicals in Rat Heart. Can. J. Physiol. Pharmacol. 69, 1459 (1991)
28. Atanasiu, R., Dumoulin, M. J., Chahine, R. et al., Antiarrhythmic Effects of Ceruloplasmin During Reperfusion in the Ischemic Isolated Rat Heart. Can. J. Physiol. Pharmacol. 73, 1253 (1995)
29. Aouffen, M., Paquin, J., De Grandpre, E. et al., Deglycosylated Ceruloplasmin Maintains Its Enzymatic, Antioxidant, Cardioprotective, and Neuronoprotective Properties. Biochem. Cell. Biol. 79, 489 (2001)
30. Mateescu, M. A., Chahine, R., Roger, S. et al., Protection of Myocardial Tissue against Deleterious Effects of Oxygen Free Radicals by Ceruloplasmin. Arzneim.-Forsch./Drug Res. 45, 476 (1995)
31. Dumoulin, M. J., Chahine, R., Atanasiu, R. et al., Comparative Antioxidant and Cardioprotective Effects of Ceruloplasmin, Superoxide Dismutase and Albumin. Arzneim.-Forsch./Drug Res. 46, 855 (1996)
32. Finley, M. F., Kulkarni, N., Huettner, J. E., Synapse Formation and Establishment of Neuronal Polarity by P19 Embryonic Carcinoma Cells and Embryonic Stem Cells. J. Neurosci. 16, 1056 (1996)
33. Parnas, D., Linial, M., Culture Density Regulates Both the Cholinergic Phenotype and the Expression of the CNTF Receptor in P19 Neurons. J. Mol. Neurosci. 8, 115 (1997)
34. Jackson, C. V., Mickelson, J. K., Stringer, K. et al., Electrolysis-Induced Myocardial Dysfunction. A Novel Method for the Study of Free Radical Mediated Tissue Injury. J. Pharmacol. Methods 15, 305 (1986)
35. Desagher, S., Glowinski, J., Premont, J., Pyruvate Protects Neurons against Hydrogen Peroxide-Induced Toxicity. J. Neurosci. 17, 9060 (1997)
36. Martin, B. J., Valdivia, H. H., Bunger, R. et al., Pyruvate Augments Calcium Transients and Cell Shortening in Rat Ventricular Myocytes. Am. J. Physiol. 274, H8 (1998)
37. Turrens, J. F., Beconi, M., Barilla, J. et al., Mitochondrial Generation of Oxygen Radicals During Reoxygenation of Ischemic Tissues. Free Radic. Res. Commun. 12-13, 681 (1991)
38. Ravingerova, T., Slezak, J., Tribulova, N. et al., Free Oxygen Radicals Contribute to High Incidence of Reperfusion-Induced Arrhythmias in Isolated Rat Heart. Life Sci. 65, 1927 (1999)
39. Borges, F., Fernandes, E., Roleira, F., Progress Towards the Discovery of Xanthine Oxidase Inhibitors. Curr. Med. Chem. 9, 195 (2002)
40. DeBoer, L. W., Bekx, P. A., Han, L. et al., Pyruvate Enhances Recovery of Rat Hearts after Ischemia and Reperfusion by Preventing Free Radical Generation. Am. J. Physiol. 265, H1571 (1993)
41. Halliwell, B., Reactive Oxygen Species and the Central Nervous System. J. Neurochem. 59, 1609 (1992)
42. Subramaniam, R., Koppal, T., Green, M. et al., The Free Radical Antioxidant Vitamin E Protects Cortical Synaptosomal Membranes from Amyloid Beta-Peptide (25-35) Toxicity but Not from Hydroxynonenal Toxicity: Relevance to the Free Radical Hypothesis of Alzheimer's Disease. Neurochem. Res. 23, 1403 (1998)
43. Maulik, N., Das, D. K., Molecular Cloning, Sequencing and Expression Analysis of a Fatty Acid Transport Gene in Rat Heart Induced by Ischemic Preconditioning and Oxidative Stress. Mol. Cell. Biochem. 160-161, 241 (1996)
44. 2 in Vitro. Brain Res. 671, 181 (1995)
45. Osakada, F., Hashino, A., Kume, T. et al., Neuroprotective Effects of Alpha-Tocopherol on Oxidative Stress in Rat Striatal Cultures. Eur. J. Pharmacol. 465, 15 (2003)
46. Godkar, P., Gordon, R. K., Ravindran, A. et al., Celastrus Paniculatus Seed Water Soluble Extracts Protect Cultured Rat Forebrain Neuronal Cells from Hydrogen Peroxide-Induced Oxidative Injury. Fitoterapia 74, 658 (2003)
47. Wei, Z., Bai, O., Richardson, J. S. et al., Olanzapine Protects PC12 Cells from Oxidative Stress Induced by Hydrogen Peroxide. J. Neurosci. Res. 73, 364 (2003)
48. Li, S. P., Zhao, K.J., Ji, Z. N. et al., A Polysaccharide Isolated from Cordyceps Sinensis, a Traditional Chinese Medicine, Protects PC12 Cells against Hydrogen Peroxide-Induced Injury. Life Sci. 73, 2503 (2003)
49. Gao, Z., Huang, K., Xu, H., Protective Effects of Flavonoids in the Roots of Scutellaria Baicalensis Georgi against Hydrogen Peroxide-Induced Oxidative Stress in HS-SY5Y Cells. Pharmacol. Res. 43, 173 (2001)
50. Moon, M. K., Choi, B. M., Oh, G. S. et al., Catalposide Protects Neuro 2a Cells from Hydrogen Peroxide-Induced Cytotoxicity Via the Expression of Heme Oxygenase-1. Toxicol. Lett. 145, 46 (2003)
51. Patel, B. N., Dunn, R. J., Jeong, S. Y. et al., Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury. J. Neurosci. 22, 6578 (2002)