Development of an efficient strategy for the synthesis of the ET B receptor antagonist BQ-788 and some related analogues

Peptides

Volumn 26, Issue 8, 2005, Pages 1441-1453

  Brosseau, Jean Philippe ^a   D'Orléans Juste, Pedro ^a   Neugebauer, Witold A ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

BQ 788; Carbamoyl chloride; ETB antagonist; IIDQ; Triphosgene; Trisubstituted urea

Indexed keywords

AMINE; ENDOTHELIN B RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PIPERIDINE DERIVATIVE; SODIUM IODIDE; UREA;

ANALYTIC METHOD; ANIMAL TISSUE; BIOASSAY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SUBSTITUTION REACTION;

ANIMALS; CAROTID ARTERY, INTERNAL; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PIPERIDINES; PULMONARY ARTERY; RABBITS; RECEPTOR, ENDOTHELIN B;

EID: 22544471802     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.03.022     Document Type: Conference Paper

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33. D = -15.4° (c = 1.419 in MeOH).